Results 71 to 80 of about 215,177 (294)

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Identifying yield-related genes in maize based on ear trait plasticity

Genome Biology, 2023
Background Phenotypic plasticity is defined as the phenotypic variation of a trait when an organism is exposed to different environments, and it is closely related to genotype. Exploring the genetic basis behind the phenotypic plasticity of ear traits in
Minguo Liu, Shuaisong Zhang, Wei Li, Xiaoming Zhao, Xi-Qing Wang   +4 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Rapid evolution in response to introduced predators II: the contribution of adaptive plasticity

BMC Evolutionary Biology, 2007
Background Introductions of non-native species can significantly alter the selective environment for populations of native species, which can respond through phenotypic plasticity or genetic adaptation.
Knapp Roland A, Bakelar Jeremy W, Latta Leigh C, Pfrender Michael E   +3 more
doaj   +1 more source

Convergent evolution of coloration in experimental introductions of the guppy (Poecilia reticulata). [PDF]

, 2018
Despite the multitude of examples of evolution in action, relatively fewer studies have taken a replicated approach to understand the repeatability of evolution.
Dick, Cynthia, Hayashi, Cheryl Y, Hinh, Jasmine, Reznick, David N   +3 more
core   +1 more source

Phenotypic Plasticity: From Microevolution to Macroevolution [PDF]

, 2014
This chapter starts with a short history of the concept of phenotypic plasticity (from the seventeenth century to present) in order to distinguish two distinct conceptions of plasticity: one more dynamic (or Aristotelian) according to which the notion has been described as a property inherent to life whose very organization depends upon it, and an ...
openaire   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Phenotypic Plasticity [PDF]

, 2008
J. Howard Frank, J. Howard Frank, Michael C. Thomas, Allan A. Yousten, F. William Howard, Robin M. Giblin-davis, John B. Heppner, Robert L. Zuparko, Norma E. Sánchez, María G. Luna, Marta Goula, John B. Heppner, Andrey N. Alekseev, Rosalind R. James, John L. Capinera, Phyllis G. Weintraub, David Horton, J. Howard Frank, Kenneth W. Mccravy, David G. Riley, David C. Marshall, Cyrus Abivardi, Marjorie A. Hoy, Efat M. Abou-fakhr hammad, Jason G. Froeba, David Legg, Heather J. Mc Auslane, Qiao Wang, Cyrus Abivardi, Seth Bybee, Menachem J. Berlinger, Sarah Lebiush-mordechi, Harold A. Denmark, J. Howard Frank, Whitney Cranshaw, John L. Capinera, John B. Heppner, Chris Asaro, Erik Christiansen, William J. Roltsch, Dale E. Meyerdirk, Lewis B. Coons, Marjorie Rothschild, Minos E. Tzanakakis, Pauline O. Lawrence, Alfred G. Wheeler, Thomas J. Henry, Russell F. Mizell, Partricia A. Mizell, John B. Heppner, Lois B. O’ brien, Menachem J. Berlinger, Anthony Rossi, Wayne B. Hunter, Charles Vincent, Gérald Chouinard, Tracy Leskey, Deborah L. Matthews, Peter G. Kevan, Antonio Felicioli, Mauro Pinzauti, Olle Pellmyr, John T. Trumble, Danel B. Vickerman, Cyrus Abivardi, Robert McSorley, K. K. Verma, John L. Capinera, Peter H. Adler, Igor Uspensky, Donald W. Hall, John L. Capinera, Juan M. Alvarez, John L. Capinera, Eugene J. Gerberg, Lawrence E. Hurd, Lawrence E. Hurd, Patrick De Clercq, John B. Heppner, J. Howard Frank, Lawrence I. Gilbert, Robert Rybczynski, Christopher Tipping, James H. Tsai, Philip Weinstein, David Slaney, Peter H. Adler, Zeyaur R. Khan, John A. Pickett, John B. Heppner, Cyrus Abivardi, Katie Goodman, Kenneth W. McCravy, Andrei Sourakov   +93 more
  +5 more sources

THE ART OF WAR: PATTERNS AND MECHANISMS UNDERLYING PREDATOR-INDUCED PLASTICITY OF AMPHIBIANS [PDF]

, 2013
Organisms often employ phenotypic plasticity as a strategy to cope with variable environments. This is particularly true of predation threats, wherein prey induce defenses to reduce detection or capture by predators.
Relyea, Rick A, Shaffery, Heather M
core  

Synthesizing the role of epigenetics in the response and adaptation of species to climate change in freshwater ecosystems [PDF]

, 2018
Freshwater ecosystems are amongst the most threatened ecosystems on Earth. Currently, climate change is one of the most important drivers of freshwater transformation and its effects include changes in the composition, biodiversity and functioning of ...
Allen, Allendorf, Alley, Andrewartha, Anway, Araújo, Ardura, Artemov, Asselman, Asselman, Avise, Baccarelli, Baerwald, Baudo, Bell, Berg, Bernardi, Bernstein, Bianchini, Bind, Bird, Bird, Blake, Bossdorf, Boutin, Brander, Bräutigam, Burggren, Bush, Carpenter, Cañedo-Argüelles, Chown, Clarke, Corcoran, Crozier, Dai, Dallas, Daxinger, Denissenko, Detrich, Dudgeon, Durance, Eros, Fasola, Feil, Fenoglio, Foley, Friberg, Fulneček, Garg, Gienapp, Glastad, Goldberg, Gonçalves, Guillette, Hanson, Harris, Heino, Henry, Hering, Hernando-Herraez, Ho, Hoegh-Guldberg, Hoffmann, Hu, Jabbari, Jablonka, Jackson, Jackson, Jaenisch, Janssens, Jiang, Karell, Karr, Kefford, Keller, Kelly, Klimenko, Klironomos, Kouzarides, Kronholm, Kronholm, Kumar, Kurdyukov, Laland, Laland, Lan, Latta, Leung, Lighten, Liu, Loureiro, Loureiro, Lämke, Manjrekar, Markovic, Martinez-Sales, Martínez-Jerónimo, Matthews, Mattick, Meissner, Mendizabal, Merilä, Merilä, Michener, Mimura, Minshull, Mirbahai, Mohseni, Moore, Mudbhary, Mulholland, Munday, Nabel, Nielsen, Norouzitallab, Parichy, Park, Pestana, Peterson, Pigliucci, Pigliucci, Pu, Qu, Rey, Ribeiro, Rinn, Ryan, Sarda, Scheiner, Scheiner, Schindler, Schrey, Shaw, Shea, Solan, Srinageshwar, Stief, Sun, Suter, Suzuki, Szabo, Sáez, Urich, Vandegehuchte, Vandegehuchte, Vannier, Varriale, Varriale, Varriale, Venâncio, Verhoeven, Verhoeven, Vogt, Vogt, Vogt, Wang, Wang, Weider, Weinberg, Weyrich, Willbanks, Williams, Wong, Woodward, Woodward, WWAP   +166 more
core   +1 more source