Results 91 to 100 of about 165,999 (264)

Catalytic residues and a predicted structure of tetrahydrobiopterin-dependent alkylglycerol mono-oxygenase [PDF]

, 2012
Alkylglycerol mono-oxygenase (EC 1.14.16.5) forms a third, distinct, class among tetrahydrobiopterin-dependent enzymes in addition to aromatic amino acid hydroxylases and nitric oxide synthases.
Albin Hermetter, Andersen, Barth, Bonneau, Dickson, Eisenberg, Ernst R. Werner, Fisher, Gabriele Werner-Felmayer, Georg Golderer, Gorgas, Hessa, Jones, Julian E. Fuchs, Kall, Katrin Watschinger, Keller, Krogh, Kuhlman, Lazaridis, Markus A. Keller, Nicolas Hulo, Rohl, Shanklin, Shanklin, Sigrist, Simons, Simons, Taguchi, Tamura, Tietz, Vladimir Yarov-Yarovoy, Watschinger, Watschinger, Werner, Werner, Wild, Yarov-Yarovoy   +37 more
core   +2 more sources

In Silico Structural Protein Evaluation of the Phenylalanine Hydroxylase p.(Tyr77His) Variant Associated with Benign Hyperphenylalaninemia as Identified through Mexican Newborn Screening. [PDF]

Children (Basel), 2023
Vela-Amieva M, Alcántara-Ortigoza MA, González-Del Angel A, Ibarra-González I, Fernández-Hernández L, Guillén-López S, López-Mejía L, Fernández-Lainez C.   +7 more
europepmc   +1 more source

Dynamic transition from $α$-helices to $β$-sheets in polypeptide superhelices [PDF]

arXiv, 2017
We carried out dynamic force manipulations $in$ $silico$ on a variety of superhelical protein fragments from myosin, chemotaxis receptor, vimentin, fibrin, and phenylalanine zippers that vary in size and topology of their $\alpha$-helical packing.
arxiv  

The aromatic amino acid hydroxylase genes AAH1 and AAH2 in Toxoplasma gondii contribute to transmission in the cat [PDF]

, 2017
The Toxoplasma gondii genome contains two aromatic amino acid hydroxylase genes, AAH1 and AAH2 encode proteins that produce L-DOPA, which can serve as a precursor of catecholamine neurotransmitters.
Dubey, Jitender P, Sibley, L. David, Verma, Shiv K, Wang, Zi T   +3 more
core   +6 more sources

72 Phenylalanine Hydroxylase Activity in Hyperphenylalanernia [PDF]

, 1967
Margaret E. O’Flynn, Parvin Justice, David Yi‐Yung Hsia, Robert B. Lawson   +3 more
openalex   +1 more source

Screening and mutation analysis of phenylalanine hydroxylase deficiency in newborns from Jiangxi province. [PDF]

Front Genet, 2023
Zeng B, Lu Q, Chen S, Guan H, Xu X, Zou Y, Wang F, Huang S, Liu Y, Yang B.   +9 more
europepmc   +1 more source

Deubiquitinase USP19 extends the residual enzymatic activity of phenylalanine hydroxylase variants. [PDF]

Sci Rep, 2022
Sarodaya N, Tyagi A, Kim HJ, Kang JS, Singh V, Hong SH, Kim WJ, Kim KS, Ramakrishna S.   +8 more
europepmc   +1 more source

Pahenu1 is a mouse model for tetrahydrobiopterin-responsive phenylalanine hydroxylase deficiency and promotes analysis of the pharmacological chaperone mechanism in vivo [PDF]

, 2017
The recent approval of sapropterin dihydrochloride, the synthetic form of 6[R]-l-erythro-5,6,7,8-tetrahydrobiopterin (BH4), for the treatment of phenylketonuria (PKU) as the first pharmacological chaperone drug initiated a paradigm change in the ...
Danecka, Marta K., Domdey, Katharina A., Eichinger, Anna, Fingerhut, Ralph, Gersting, Søren W., Glossmann, Hartmut, Kemter, Kristina F., Lagler, Florian B., Messing, Dunja D., Muntau, Ania C., Roscher, Adelbert A., Staudigl, Michael, Zsifkovits, Clemens   +12 more
core  

Thermodynamics of iron, tetrahydrobiopterin, and phenylalanine binding to phenylalanine hydroxylase from Chromobacterium violaceum. [PDF]

Arch Biochem Biophys, 2022
Li M, Subedi BP, Fitzpatrick PF, Emerson JP.   +3 more
europepmc   +1 more source

Unveiling Parkinson's Disease-like Changes Triggered by Spaceflight [PDF]

arXiv
A meta-analysis of spaceflight data from both mouse and human flights reveals a striking overlap with Parkinson's disease (PD). Parallels include: changes in gait, loss of dopamine, sustained changes in the basal ganglia, loss of tyrosine hydroxylase in the substantia nigra, and systemic mitochondrial dysfunction.
arxiv