Results 1 to 10 of about 35,483 (216)

Phenytoin-induced Ogilvie syndrome: A rare case report [PDF]

SAGE Open Medical Case Reports
Phenytoin is a widely prescribed antiepileptic drug that is associated with various adverse effects, but gastrointestinal manifestations are rare. Therapeutic drug monitoring is essential for ensuring safe and effective dosing by measuring the drug ...
Joel Sabu, Kevin Jose Madapat, Namitha K. Baby   +2 more
doaj   +2 more sources

Hepatoprotective potential of N-acetyl cysteine in rats with phenytoin induced liver injury [version 1; peer review: 2 approved] [PDF]

F1000Research
Background Phenytoin is an anticonvulsant medication that is effective in treating various seizure disorders. It is mostly metabolized by the liver, which increases the risk of PHT-induced hepatotoxicity. Aims This study aimed to assess the effectiveness
Fadhaa Abdulameer Ghafil, Sahar A. Majeed, Zahraa Abed Al-kareem, Amal Umran Mosa, Deema Diyaa Azeez, Noor D. Aziz   +5 more
doaj   +2 more sources

Phenytoin induced Chorea: commonly used antiepileptic drug causing a rare movement disorder [PDF]

Asia Pacific Journal of Medical Toxicology, 2020
Background: Phenytoin, a commonly prescribed antiepileptic drug, causes side effects like ataxia, tremor, hirsutism, gum hyperplasia, insomnia, confusion, headache and vertigo when used for longer duration.
Rambhupal NAGIREDDY, Deepika Joshi, Sooraj Patil, Anand Kumar   +3 more
doaj   +1 more source

Phenytoin as seizure prophylaxis in hematopoietic stem cell transplantation with busulfan conditioning

Frontiers in Neurology, 2022
BackgroundPhenytoin is widely used as primary seizure prophylaxis in hematopoietic stem cell transplantation in patients undergoing myeloablative conditioning with busulfan. Because of the negative side effects of phenytoin, we abandoned phenytoin use in
R. S. Germeraad, A. M. P. Demandt, R. P. W. Rouhl, R. P. W. Rouhl, R. P. W. Rouhl   +4 more
doaj   +1 more source

Effect of Topical Phenytoin in Treatment of Corneal Epithelial Defect in Rabbits [PDF]

Trends in Pharmaceutical Sciences, 2018
Re-epithelialization of corneal epithelium is a major problem in delayed corneal wound healing. Phenytoin has been used topically for different type of cutaneous wounds and ulcers.
Masoomeh Eghtedari, Vahid Beigi, Mohammad Reza Soltani   +2 more
doaj   +3 more sources

The role of heat-not-burn, snus and other nicotine-containing products as interventions for epileptic patients who take phenytoin and smoke cigarettes

Toxicology Reports, 2022
Background: Cigarette smoke increases the metabolism of phenytoin, a widely used anti-epileptic agent, by inducing cytochrome P450 enzymes in the liver. Therefore, cigarette smoke may reduce the clinical effect of phenytoin.
P.N. Valodia
doaj   +1 more source

Does long‐term phenytoin have a place in Dravet syndrome?

Annals of Clinical and Translational Neurology, 2022
Anti‐seizure medications that block sodium channels are generally considered contraindicated in Dravet syndrome. There is, however, considerable debate about the sodium‐channel blocker phenytoin, which is often used for status epilepticus, a frequent ...
George A. Zographos, Sophie J. Russ‐Hall, Ingrid E. Scheffer   +2 more
doaj   +1 more source

Clinical decision support of therapeutic drug monitoring of phenytoin: measured versus adjusted phenytoin plasma concentrations

BMC Medical Informatics and Decision Making, 2012
Background Therapeutic drug monitoring of phenytoin by measurement of plasma concentrations is often employed to optimize clinical efficacy while avoiding adverse effects.
Krasowski Matthew D, Penrod Louis E
doaj   +1 more source

Restoration of Germinal Epithelium with Usage of Antioxidant Oils in Phenytoin Induced Testicular Toxicity: A Comparative Study in Rats

Journal of Bahria University Medical and Dental College, 2023
Objective: To evaluate antioxidant effect of Virgin Coconut Oil (VCO) and Corn Oil (CO) on germinal thickness (GT) in rats induced with phenytoin toxicity. Study design and setting: An Experimental Longitudinal study was done at AL-Tibri Medical College
Khalique-ur- Rehman, Syed Muhammad Masood Ali, Khalid Shehzad, Sonia Khan, Sarah Sughra, Hina Khan   +5 more
doaj   +1 more source

Enriched enrollment randomized double-blind placebo-controlled cross-over trial with phenytoin cream in painful chronic idiopathic axonal polyneuropathy (EPHENE): a study protocol

Trials, 2022
Background Patients with chronic idiopathic axonal polyneuropathy (CIAP) can have neuropathic pain that significantly impacts quality of life. Oral neuropathic pain medication often has insufficient pain relief and side effects.
David J. Kopsky, Ruben P. A. van Eijk, Janna K. Warendorf, Jan M. Keppel Hesselink, Nicolette C. Notermans, Alexander F. J. E. Vrancken   +5 more
doaj   +1 more source