Results 31 to 40 of about 65,177 (296)

Clinical decision support of therapeutic drug monitoring of phenytoin: measured versus adjusted phenytoin plasma concentrations

open access: yesBMC Medical Informatics and Decision Making, 2012
Background Therapeutic drug monitoring of phenytoin by measurement of plasma concentrations is often employed to optimize clinical efficacy while avoiding adverse effects.
Krasowski Matthew D, Penrod Louis E
doaj   +1 more source

Restoration of Germinal Epithelium with Usage of Antioxidant Oils in Phenytoin Induced Testicular Toxicity: A Comparative Study in Rats

open access: yesJournal of Bahria University Medical and Dental College, 2023
Objective: To evaluate antioxidant effect of Virgin Coconut Oil (VCO) and Corn Oil (CO) on germinal thickness (GT) in rats induced with phenytoin toxicity. Study design and setting: An Experimental Longitudinal study was done at AL-Tibri Medical College
Khalique-ur- Rehman   +5 more
doaj   +1 more source

Enriched enrollment randomized double-blind placebo-controlled cross-over trial with phenytoin cream in painful chronic idiopathic axonal polyneuropathy (EPHENE): a study protocol

open access: yesTrials, 2022
Background Patients with chronic idiopathic axonal polyneuropathy (CIAP) can have neuropathic pain that significantly impacts quality of life. Oral neuropathic pain medication often has insufficient pain relief and side effects.
David J. Kopsky   +5 more
doaj   +1 more source

Infusion dose requirement of rocuronium in patients on phenytoin therapy – A prospective comparative study

open access: yesIndian Journal of Anaesthesia, 2017
Background and Aims: Patients with intracranial tumour are usually on anticonvulsants. Patients on phenytoin therapy demonstrate rapid metabolism of nondepolarising muscle relaxants secondary to enzyme induction.
Veena Sheshadri   +3 more
doaj   +1 more source

Phenytoin Toxicity with High Dose, Concomitant Ascorbic Acid Dosing

open access: yesINNOVATIONS in Pharmacy, 2022
High dose ascorbic acid may increase risk of phenytoin toxicity. This case report demonstrates high phenytoin levels resulting in adverse drug reactions subsequent to dosing concomitantly with high dose vitamin C, or ascorbic acid (AA), as a precaution ...
Michael J. Schuh   +2 more
doaj   +1 more source

Anticonvulsant Effect of Nebivolol alone and in Combination with Phenytoin against Maximal Electroshock-Induced Seizures in Mice [PDF]

open access: yesJournal of Clinical and Diagnostic Research, 2021
Introduction: Phenytoin is widely used in treatment of generalised tonic clonic seizures but its adverse effects make its usage limited. Hence forth, there is a need for newer antiepileptics. Studies have shown antiepileptic property for nebivolol in
Anuranjani Dhamodharan   +2 more
doaj   +1 more source

Expression of VEGF and TGF-β Genes in Skin Wound Healing Process Induced Using Phenytoin in Male Rats

open access: yesJundishapur journal of health sciences, 2019
Background: Phenytoin is one of the most important chemical drugs used for the treatment of skin wound. Objectives: In the present study, the molecular effect of phenytoin on the expression of VEGF and TGF-β genes was investigated.
Roghaye Savari   +3 more
semanticscholar   +1 more source

Phenytoin regulates osteogenic differentiation of human bone marrow stem cells by PI3K/Akt pathway

open access: yesRegenerative Therapy, 2023
Background: We mainly studied the mechanism by which phenytoin promotes osteogenic differentiation of human jawbone marrow stem cells. Methods: Bone marrow stem cells were extracted from jaw bone tissue debris obtained from 5 subjects undergoing implant ...
Zeliang Zhang   +3 more
doaj   +1 more source

Acute Phenytoin Intoxication: Causes, Symptoms, Misdiagnoses, and Outcomes

open access: yesKaohsiung Journal of Medical Sciences, 2004
Phenytoin is a commonly prescribed antiepileptic drug. Due to its saturation (zero-order) pharmacokinetics, phenytoin carries a special risk of dose-related toxicity that is an important issue in emergency medicine.
Wen-Juh Hwang, Jing-Jane Tsai
doaj   +1 more source

IV Levetiracetam versus IV Phenytoin in Childhood Seizures: A Randomized Controlled Trial

open access: yesJournal of Pediatric Neurosciences, 2018
Objectives: To compare the efficacy of IV phenytoin and IV levetiracetam in acute seizures. Design: Randomized controlled trial. Setting: Tertiary care hospital, November 2012 to April 2014.
Kanika Singh   +3 more
semanticscholar   +1 more source

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