Results 41 to 50 of about 65,177 (296)

No Detectable Phenytoin Plasma Levels After Topical Phenytoin Cream Application in Chronic Pain: Inferences for Mechanisms of Action

Journal of Pain Research, 2022
David J Kopsky,1,2 Jan M Keppel Hesselink,1 Alan L Russell,3 Alexander FJE Vrancken2 1Institute for Neuropathic Pain, Amsterdam, the Netherlands; 2Department of Neurology, Brain Centre University Medical Center Utrecht, Utrecht University, Utrecht, the ...
Kopsky DJ, Keppel Hesselink JM, Russell AL, Vrancken AFJE   +3 more
doaj  

Topical phenytoin for the treatment of neuropathic pain

Journal of Pain Research, 2017
We developed and tested a new putative analgesic cream, based on the anticonvulsant phenytoin in patients suffering from treatment refractory neuropathic pain.
D. J. Kopsky, J. K. Keppel Hesselink
semanticscholar   +1 more source

Effect of Pioglitazone on Plasma Levels of Phenytoin in Rats [PDF]

Journal of Cardio-Thoracic Medicine, 2013
Introduction: Interaction between drugs represents a major clinical concern for health care professionals and their patients. Patients affected by both type 2 diabetes and epilepsy may be prescribed pioglitazone and an anti-epileptic drug such as ...
Abolghasem Jouyban, Morteza Samini, Ali Shayanfar, Hamed Ghavimi   +3 more
doaj   +2 more sources

Prophylactic Use of Antiepileptic Drug (Phenytoin) in Preventing Early Postoperative Seizure in Patients with Chronic Subdural Hematoma: A Randomized Control Trial

Indian Journal of Neurosurgery, 2019
Introduction Antiepileptic drug (AED) therapy has been used prophylactically in various centers in patients with chronic subdural hematoma (CSDH) after surgical evacuation, although the benefit is unclear.
Amit Bahadur Pradhanang, Gopal Sedain, Sushil K. Shilpakar, Mohan Raj Sharma   +3 more
doaj   +1 more source

Phenytoin inhibits necroptosis

Cell Death and Disease, 2018
Receptor-interacting protein kinases 1 and 3 (RIPK1/3) have best been described for their role in mediating a regulated form of necrosis, referred to as necroptosis.
Anne von Mässenhausen, W. Tonnus, N. Himmerkus, S. Parmentier, Danish Saleh, D. Rodriguez, J. Ousingsawat, Rosalind L. Ang, J. Weinberg, A. Sanz, A. Ortiz, Adrian Zierleyn, J. Becker, B. Baratte, N. Desban, S. Bach, I. Schiessl, Shoko Nogusa, Siddharth Balachandran, H. Anders, A. Ting, M. Bleich, A. Degterev, K. Kunzelmann, S. Bornstein, D. Green, C. Hugo, A. Linkermann   +27 more
semanticscholar   +1 more source

Oral Phenytoin Toxicity Causing Sinus Arrest: A Case Report

Case Reports in Cardiology, 2014
We present a case of sinus node arrest leading to symptomatic junctional bradycardia from oral phenytoin toxicity, which is a rare presentation. Our patient had no prior cardiac history and was on phenytoin therapy for seizure disorder.
Ravi K. Thimmisetty, Janardhana Rao Gorthi, Mahmoud Abu Hazeem   +2 more
doaj   +1 more source

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

Total Phenytoin concentration is not well correlated with active free drug in critically-ill head trauma patients

Journal of Research in Pharmacy Practice, 2013
Objective: Phenytoin is an antiepileptic drug used widely for prophylaxis and treatment of seizure after neurotrauma. Phenytoin has a complex pharmacokinetics and monitoring of its serum concentrations is recommended during treatment.
Kourosh Sadeghi, Farin Hadi, Arezoo Ahmadi, Hadi Hamishehkar, Mohammad-Taghi Beigmohammadi, Ata Mahmoodpoor, Mohammad Reza Rouini, Shirin Farhudi, Narjes Hendoui, Atabak Najafi, Mojtaba Mojtahedzadeh   +10 more
doaj   +1 more source

Radiosynthesis of 11C-phenytoin Using a DEGDEE Solvent for Clinical PET Studies [PDF]

Asia Oceania Journal of Nuclear Medicine and Biology, 2018
Objective(s): Phenytoin is an antiepileptic drug that is used worldwide.The whole-body pharmacokinetics of this drug have been extensivelystudied using 11C-phenytoin in small animals.
Yasukazu Kanai, Yoshinori Miyake, Jun Hatazawa   +2 more
doaj   +1 more source

CAQ Corner: Basic concepts of transplant immunology

, 2022
Liver Transplantation, EarlyView.
Amanda Cheung, Josh Levitsky
wiley   +1 more source