Results 41 to 50 of about 93,963 (358)

Phenytoin regulates osteogenic differentiation of human bone marrow stem cells by PI3K/Akt pathway

Regenerative Therapy, 2023
Background: We mainly studied the mechanism by which phenytoin promotes osteogenic differentiation of human jawbone marrow stem cells. Methods: Bone marrow stem cells were extracted from jaw bone tissue debris obtained from 5 subjects undergoing implant ...
Zeliang Zhang, Wei Shang, Xicong Zhao, Lisong Lin   +3 more
doaj   +1 more source

Searching for New Leads to Treat Epilepsy: Target-Based Virtual Screening for the Discovery of Anticonvulsant Agents [PDF]

, 2018
The purpose of this investigation is to contribute to the development of new anticonvulsant drugs to treat patients with refractory epilepsy. We applied a virtual screening protocol that involved the search into molecular databases of new compounds and ...
Bruno Blanch, Luis Enrique, Enrique, Nicolás Jorge, Gavernet, Luciana, Goicoechea, Sofia, Martín, Pedro, Milesi, Verónica, Palestro, Pablo Hernán, Sabatier, Laureano Leonel, Villalba, Maria Luisa   +8 more
core   +2 more sources

Phenytoin inhibits necroptosis

Cell Death and Disease, 2018
Receptor-interacting protein kinases 1 and 3 (RIPK1/3) have best been described for their role in mediating a regulated form of necrosis, referred to as necroptosis.
Anne von Mässenhausen, W. Tonnus, N. Himmerkus, S. Parmentier, Danish Saleh, D. Rodriguez, J. Ousingsawat, Rosalind L. Ang, J. Weinberg, A. Sanz, A. Ortiz, Adrian Zierleyn, J. Becker, B. Baratte, N. Desban, S. Bach, I. Schiessl, Shoko Nogusa, Siddharth Balachandran, H. Anders, A. Ting, M. Bleich, A. Degterev, K. Kunzelmann, S. Bornstein, D. Green, C. Hugo, A. Linkermann   +27 more
semanticscholar   +1 more source

Acute Phenytoin Intoxication: Causes, Symptoms, Misdiagnoses, and Outcomes

Kaohsiung Journal of Medical Sciences, 2004
Phenytoin is a commonly prescribed antiepileptic drug. Due to its saturation (zero-order) pharmacokinetics, phenytoin carries a special risk of dose-related toxicity that is an important issue in emergency medicine.
Wen-Juh Hwang, Jing-Jane Tsai
doaj   +1 more source

No Detectable Phenytoin Plasma Levels After Topical Phenytoin Cream Application in Chronic Pain: Inferences for Mechanisms of Action

Journal of Pain Research, 2022
David J Kopsky,1,2 Jan M Keppel Hesselink,1 Alan L Russell,3 Alexander FJE Vrancken2 1Institute for Neuropathic Pain, Amsterdam, the Netherlands; 2Department of Neurology, Brain Centre University Medical Center Utrecht, Utrecht University, Utrecht, the ...
Kopsky DJ, Keppel Hesselink JM, Russell AL, Vrancken AFJE   +3 more
doaj  

Antiepileptic drugs reduce serum uric acid [PDF]

, 1987
Uric acid examination in 554 epileptic out-patients under long-term anticonvulsant medication revealed significantly lower serum concentrations compared to a group of normal controls.
Arab, Bernhard Schellenberg, Heinrich Schmidt-Gayk, Klaus-Henning Krause, Meinardi, Peter Berlit, Richens, Yeung   +7 more
core   +1 more source

Dissolution enhancement of gliclazide using pH change approach in presence of twelve stabilizers with various physico-chemical properties [PDF]

, 2009
Purpose. The micronization using milling process to enhance dissolution rate is extremely inefficient due to a high energy input, and disruptions in the crystal lattice which can cause physical or chemical instability.
Mostafavi, Seyed Abolfazl, Nokhodchi, Ali, Talari, Roya, Varshosaz, Jaleh   +3 more
core   +2 more sources

Prophylactic Use of Antiepileptic Drug (Phenytoin) in Preventing Early Postoperative Seizure in Patients with Chronic Subdural Hematoma: A Randomized Control Trial

Indian Journal of Neurosurgery, 2019
Introduction Antiepileptic drug (AED) therapy has been used prophylactically in various centers in patients with chronic subdural hematoma (CSDH) after surgical evacuation, although the benefit is unclear.
Amit Bahadur Pradhanang, Gopal Sedain, Sushil K. Shilpakar, Mohan Raj Sharma   +3 more
doaj   +1 more source

Topical phenytoin for the treatment of neuropathic pain

Journal of Pain Research, 2017
We developed and tested a new putative analgesic cream, based on the anticonvulsant phenytoin in patients suffering from treatment refractory neuropathic pain.
D. J. Kopsky, J. K. Keppel Hesselink
semanticscholar   +1 more source

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source