Results 1 to 10 of about 8,553 (204)

AKR7A3 modulates the metastasis of pancreatic ductal adenocarcinoma through regulating PHGDH‐suppressed autophagy

Cancer Science, 2023
AKR7A3 is a member of the aldo‐keto reductase (AKR) protein family, whose primary purpose is to reduce aldehydes and ketones to generate primary and secondary alcohols. It has been reported that AKR7A3 is downregulated in pancreatic cancer (PC). However,
Lei Hua, Yang Song, J. Min, Ronglin Wang, Hong Li, Liaoliao Zhu, Yongdong Guo, Dongxue Gan, Shanshan Li, Peixiang Ma, Cheng Yang, Jing Yang, Jingjie Shi, Junqiang Li, Haichuan Su   +14 more
semanticscholar   +2 more sources

Clioquinol as a new therapy in epilepsy: From preclinical evidence to a proof-of-concept clinical study. [PDF]

Epilepsia
Abstract Objective Drug‐resistant epilepsy (DRE) affects >25 million people worldwide and is often associated with neuroinflammation. Increasing evidence links deficiency or malfunctioning of the enzyme phosphoglycerate dehydrogenase (PHGDH), which converts 3‐phosphoglycerate to generate serine and the neurotransmitter glycine, with (drug‐resistant ...
Thevissen K, Ny A, Copmans D, Tits J, Kamata K, Gielis E, Longin K, Sourbron J, Thergarajan P, Tan TH, Ali I, Jones NC, O'Brien TJ, Monif M, Semple BD, Germeys C, Frizzi B, Minniti V, Perrone S, Linster CL, Elia I, Van Den Bosch L, Cammue BPA, Voet A, Lagae L, de Witte P.   +25 more
europepmc   +2 more sources

Targeting PHGDH reverses the immunosuppressive phenotype of tumor-associated macrophages through α-ketoglutarate and mTORC1 signaling [PDF]

Cellular & Molecular Immunology
Phosphoglycerate dehydrogenase (PHGDH) has emerged as a crucial factor in macromolecule synthesis, neutralizing oxidative stress, and regulating methylation reactions in cancer cells, lymphocytes, and endothelial cells.
Zhengnan Cai, Wan Li, Sonja Hager, Jayne Louise Wilson, Leila Afjehi-Sadat, Elke H. Heiss, T. Weichhart, P. Heffeter, W. Weckwerth   +8 more
semanticscholar   +2 more sources

Integrative metabolome and transcriptome analyses provide insights into PHGDH in colon cancer organoids. [PDF]

Biosci Rep
As a rate-limiting enzyme in the endogenous serine de novo synthesis pathway, 3-Phosphoglycerate dehydrogenase (PHGDH) has been widely concerned about its role in a variety of tumors including colon cancer and the development of inhibitors.
Chen L, Dai Z, Zhang Y, Sheng H, Hu B, Du J, Chang J, Xu W, Hu Y.   +8 more
europepmc   +2 more sources

Serine synthesis pathway enzyme PHGDH is critical for muscle cell biomass, anabolic metabolism and mTORC1 signaling.

American Journal of Physiology. Endocrinology and Metabolism, 2023
Cells use glycolytic intermediates for anabolism e.g., via the serine synthesis and pentose phosphate pathways. However, we still understand poorly how these metabolic pathways contribute to skeletal muscle cell biomass generation.
Sakari Mäntyselkä, Kalle Kolari, P. Baumert, Laura Ylä-Outinen, Lauri Kuikka, Suvi Lahtonen, P. Permi, Henning Wackerhage, Elina Kalenius, R. Kivelä, J. Hulmi   +10 more
semanticscholar   +3 more sources

PHGDH Induction by MAPK Is Essential for Melanoma Formation and Creates an Actionable Metabolic Vulnerability. [PDF]

Cancer Res
Overexpression of PHGDH, the rate-limiting enzyme in the serine synthesis pathway, promotes melanomagenesis, melanoma cell proliferation, and survival of metastases in serine-low environments such as the brain.
Jasani N, Xu X, Posorske B, Kim Y, Wang K, Vera O, Tsai KY, DeNicola GM, Karreth FA.   +8 more
europepmc   +2 more sources

Identification of novel PHGDH inhibitors based on computational investigation: an all-in-one combination strategy to develop potential anti-cancer candidates

Frontiers in Pharmacology
Objective Biological studies have elucidated that phosphoglycerate dehydrogenase (PHGDH) is the rate-limiting enzyme in the serine synthesis pathway in humans that is abnormally expressed in numerous cancers.
Yujing Xu, Zhe Yang, Jinrong Yang, Chunchun Gan, Nan Qin, Xiaopeng Wei   +5 more
semanticscholar   +2 more sources

CLN5 deficiency impairs glucose uptake and uncovers PHGDH as a potential biomarker in Batten disease. [PDF]

Mol Psychiatry
Marchese M, Bernardi S, Vivarelli R, Doccini S, Santucci L, Ogi A, Licitra R, Zang J, Soliymani R, Mero S, Neuhauss SC, Ciarmoli L, Signore G, Lalowski MM, Santorelli FM.   +14 more
europepmc   +3 more sources

PHGDH-mediated serine synthesis in astrocytes supports neuroinflammation by sustaining NADH level to promote histone acetylation. [PDF]

Cell Death Dis
Lv M, Duan Z, Tan J, Liu J, Wang Q, Wang C, Zhang Z, Sun X, Liu R, Cui Y.   +9 more
europepmc   +3 more sources

PHGDH arginine methylation by PRMT1 promotes serine synthesis and represents a therapeutic vulnerability in hepatocellular carcinoma

Nature Communications, 2023
The role of protein arginine methylation in serine metabolism of cancer cells in hepatocellular carcinoma (HCC) remains to be explored. Here, the authors show that phosphoglycerate dehydrogenase (PHGDH) is activated by PRMT1-mediated R236 methylation ...
Kui Wang, Li Luo, Shuyue Fu, Mao Wang, Zihao Wang, Lixia Dong, Xingyun Wu, Lunzhi Dai, Yong Peng, G. Shen, Haining Chen, E. Nice, Xiawei Wei, Canhua Huang   +13 more
semanticscholar   +1 more source