Results 1 to 10 of about 8,290 (226)

m6A modification and SUMOylation of PHGDH regulates ulcerative colitis through autophagy [PDF]

Cellular and Molecular Life Sciences
Background Ulcerative colitis (UC) is a chronic inflammatory bowel disorder with increasing incidence globally. However, the understanding of UC pathogenesis remains limited. Methods DSS-induced UC mouse model and lipopolysaccharide (LPS)-treated colonic
Hui Xue, Dandan Wang, Chengjian Pang, Yue Shen, Jingjing Xu, Lize Zhang   +5 more
doaj   +3 more sources

PHGDH activation fuels glioblastoma progression and radioresistance via serine synthesis pathway [PDF]

Journal of Experimental & Clinical Cancer Research
Background Glioma stem-like cells (GSCs) are key drivers of treatment resistance and recurrence in glioblastoma (GBM). Phosphoglycerate dehydrogenase (PHGDH), a crucial enzyme in the de novo serine synthesis pathway (SSP), is implicated in tumorigenesis ...
Xiaojin Liu, Bangxin Liu, Junwen Wang, Hongbin Liu, Jiasheng Wu, Yiwei Qi, Yuan Liu, Hongtao Zhu, Chaoxi Li, Liu Yang, Jian Song, Guojie Yao, Weidong Tian, Kai Zhao, Lin Han, Kai Shu, Suojun Zhang, Jianghong Man, Chao You, Haohao Huang, Ran Li   +20 more
doaj   +4 more sources

PHGDH-dependent serine metabolism in astrocytes: A key regulator of oxidative stress and pyroptosis in cerebral ischemia-reperfusion injury [PDF]

Redox Biology
Phosphoglycerate dehydrogenase (PHGDH) is a key molecule in the progression of Alzheimer's disease. Herein, we report that PHGDH exerts a significant influence on cerebral ischemia-reperfusion injury (CIRI).
Jimeng Zhang, Yaowen Luo, Changcai Xie, Min Zhang, Heyao Qin, Yuefei Zhou, Xiuquan Wu, Chenchen Hu, Feiming Hu, Xiaowei Fei, Hongchen Zhang, Juan Li, Yihao Fu, Yunchao Yuan, Shuya Yang, Dakuan Gao   +15 more
doaj   +2 more sources

Integrative Bioinformatics Reveals Novel Molecular Mechanisms and Therapeutic Targets in Acute Myeloid Leukaemia. [PDF]

J Cell Mol Med
ABSTRACT Acute myeloid leukaemia (AML) is a genetically heterogeneous malignancy associated with poor prognosis and limited treatment options. To identify molecular programs conserved across AML subtypes and perturbations, we analysed three RNA sequencing datasets that captured venetoclax treatment under metabolic stress and the knockdown of chromatin ...
Daniel MM, Andwey GH.
europepmc   +2 more sources

PHGDH drives 5-FU chemoresistance in colorectal cancer through the Hedgehog signaling [PDF]

Journal of Experimental & Clinical Cancer Research
Background Phosphoglycerate dehydrogenase (PHGDH) is the rate-limiting enzyme in the de novo Serine synthesis pathway (SSP), a highly regulated pathway overexpressed in several tumors.
Caterina Mancini, Giulia Lori, Gianluca Mattei, Marta Iozzo, Dayana Desideri, Fabio Cianchi, Laura Fortuna, Federico Passagnoli, Daniela Massi, Filippo Ugolini, Luca Messerini, Salvatore Piscuoglio, Antonio Pezone, Francesca Magherini, Alessio Biagioni, Tiziano Lottini, Demetra Zambardino, Giuseppina Ivana Truglio, Elena Petricci, Alberto Magi, Annarosa Arcangeli, Luisa Maresca, Barbara Stecca, Erica Pranzini, Maria Letizia Taddei   +24 more
doaj   +2 more sources

PHGDH at the crossroads: metabolic plasticity, metastatic paradoxes, and therapeutic reconnaissance in cancer [PDF]

Journal of Biomedical Science
Phosphoglycerate dehydrogenase (PHGDH), the rate-limiting enzyme of the serine biosynthesis pathway (SSP), is a central metabolic hub and multifunctional oncoprotein that drives tumorigenesis through both canonical and non-canonical mechanisms.
Liang Hao, Bai-Qiang Li, Shi-Yang Lu, Zhong-Cai An, Zheng-Yuan Yin, Zhen-Xian Du, Hua-Qin Wang   +6 more
doaj   +2 more sources

Phosphoglycerate dehydrogenase stabilizes protein kinase C delta type mRNA to promote hepatocellular carcinoma progression [PDF]

Signal Transduction and Targeted Therapy
Metabolic reprogramming not only reshapes cellular bioenergetics but also profoundly influences RNA metabolism through metabolite signaling and the RNA-binding activities of metabolic enzymes.
Bin Cheng, Pai Peng, Shi Chen, Rui Liu, Xiaosong Li, Ke Wang, Jing Ma, Kai Wang, Ni Tang, Ailong Huang   +9 more
doaj   +2 more sources

Nuclear PHGDH regulates macrophage polarization through transcriptional repression of GLUD1 and GLS2 in breast cancer [PDF]

Cancer Biology & Medicine
Objective: Tumor-associated macrophages (TAMs) exhibit heterogeneous properties including anti-tumorigenic and pro-tumorigenic phenotypes. The rate-limiting enzyme in de novo serine biosynthesis, 3-phosphoglycerate dehydrogenase (PHGDH), has a well ...
Pei Wang, Xin Du, Zhiren Han, Jiaxin Zhong, Jiayu Yuan, Lin Jiang, Beinan Han, Wenkui Fu, Hongde Li, Hai Hu, Zhenkun Na   +10 more
doaj   +2 more sources

PHGDH-mediated serine synthesis in astrocytes supports neuroinflammation by sustaining NADH level to promote histone acetylation [PDF]

Cell Death and Disease
Neuroinflammation contributes to the loss of dopamine neurons and motor dysfunctions in Parkinson’s disease (PD). How cell metabolism regulates neuroinflammation by modulating epigenetic modifications is largely unknown.
Mengfei Lv, Zhongying Duan, Jinhua Tan, Jiake Liu, Qinqin Wang, Congxiao Wang, Zhaolong Zhang, Xiaona Sun, Rui Liu, Yu Cui   +9 more
doaj   +2 more sources

YY2 mediates transcriptional repression of PHGDH and expedites oxidative stress in retinal pigment epithelial cells in diabetic retinopathy [PDF]

Journal of Diabetes Investigation
Aims/Introduction Phosphoglycerate dehydrogenase (PHGDH), which controls serine synthesis, has been linked to retinal disease. However, there are no clues about its involvement in the diabetic retinopathy (DR) progression.
Xiang Lei, Xiu Wang, Xinai Zhang
doaj   +2 more sources