Results 1 to 10 of about 8,013 (194)

m6A modification and SUMOylation of PHGDH regulates ulcerative colitis through autophagy [PDF]

Cellular and Molecular Life Sciences
Background Ulcerative colitis (UC) is a chronic inflammatory bowel disorder with increasing incidence globally. However, the understanding of UC pathogenesis remains limited. Methods DSS-induced UC mouse model and lipopolysaccharide (LPS)-treated colonic
Hui Xue, Dandan Wang, Chengjian Pang, Yue Shen, Jingjing Xu, Lize Zhang   +5 more
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PHGDH-dependent serine metabolism in astrocytes: A key regulator of oxidative stress and pyroptosis in cerebral ischemia-reperfusion injury [PDF]

Redox Biology
Phosphoglycerate dehydrogenase (PHGDH) is a key molecule in the progression of Alzheimer's disease. Herein, we report that PHGDH exerts a significant influence on cerebral ischemia-reperfusion injury (CIRI).
Jimeng Zhang, Yaowen Luo, Changcai Xie, Min Zhang, Heyao Qin, Yuefei Zhou, Xiuquan Wu, Chenchen Hu, Feiming Hu, Xiaowei Fei, Hongchen Zhang, Juan Li, Yihao Fu, Yunchao Yuan, Shuya Yang, Dakuan Gao   +15 more
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Multi-omics Analysis of the Role of PHGDH in Colon Cancer

Technology in Cancer Research & Treatment, 2023
Objectives : Serine metabolism is essential for tumor cells. Endogenous serine arises from de novo synthesis pathways. As the rate-limiting enzyme of this pathway, PHGDH is highly expressed in a variety of tumors including colon cancer.
Zhihui Dai MSc, Lin Chen MSc, KaiLing Pan MSc, XiaoYa Zhao MSc, WenXia Xu PhD, JinLin Du MD, Chungen Xing PhD   +6 more
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PHGDH at the crossroads: metabolic plasticity, metastatic paradoxes, and therapeutic reconnaissance in cancer [PDF]

Journal of Biomedical Science
Phosphoglycerate dehydrogenase (PHGDH), the rate-limiting enzyme of the serine biosynthesis pathway (SSP), is a central metabolic hub and multifunctional oncoprotein that drives tumorigenesis through both canonical and non-canonical mechanisms.
Liang Hao, Bai-Qiang Li, Shi-Yang Lu, Zhong-Cai An, Zheng-Yuan Yin, Zhen-Xian Du, Hua-Qin Wang   +6 more
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XPR1 downregulation inhibits hepatocellular carcinoma progression by suppressing serine metabolism [PDF]

Redox Biology
Xenotropic and polytropic retrovirus receptor 1 (XPR1) is highly expressed in various tumors and is associated with poor clinical prognosis, making it a proposed therapeutic target for cancer. However, the mechanism of XPR1 in tumorigenesis, particularly
Zi-qiang Liao, Ze-ning Chen, Yang-feng Lv, Yuan-yuan Zhang, Zhi-xing Liu, Zhi-qiang Deng, Qing-rong Liang, Chun-bo Zhang, Qun Tang   +8 more
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PHGDH drives 5-FU chemoresistance in colorectal cancer through the Hedgehog signaling [PDF]

Journal of Experimental & Clinical Cancer Research
Background Phosphoglycerate dehydrogenase (PHGDH) is the rate-limiting enzyme in the de novo Serine synthesis pathway (SSP), a highly regulated pathway overexpressed in several tumors.
Caterina Mancini, Giulia Lori, Gianluca Mattei, Marta Iozzo, Dayana Desideri, Fabio Cianchi, Laura Fortuna, Federico Passagnoli, Daniela Massi, Filippo Ugolini, Luca Messerini, Salvatore Piscuoglio, Antonio Pezone, Francesca Magherini, Alessio Biagioni, Tiziano Lottini, Demetra Zambardino, Giuseppina Ivana Truglio, Elena Petricci, Alberto Magi, Annarosa Arcangeli, Luisa Maresca, Barbara Stecca, Erica Pranzini, Maria Letizia Taddei   +24 more
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Phosphoglycerate dehydrogenase stabilizes protein kinase C delta type mRNA to promote hepatocellular carcinoma progression [PDF]

Signal Transduction and Targeted Therapy
Metabolic reprogramming not only reshapes cellular bioenergetics but also profoundly influences RNA metabolism through metabolite signaling and the RNA-binding activities of metabolic enzymes.
Bin Cheng, Pai Peng, Shi Chen, Rui Liu, Xiaosong Li, Ke Wang, Jing Ma, Kai Wang, Ni Tang, Ailong Huang   +9 more
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PHGDH-mediated serine synthesis in astrocytes supports neuroinflammation by sustaining NADH level to promote histone acetylation [PDF]

Cell Death and Disease
Neuroinflammation contributes to the loss of dopamine neurons and motor dysfunctions in Parkinson’s disease (PD). How cell metabolism regulates neuroinflammation by modulating epigenetic modifications is largely unknown.
Mengfei Lv, Zhongying Duan, Jinhua Tan, Jiake Liu, Qinqin Wang, Congxiao Wang, Zhaolong Zhang, Xiaona Sun, Rui Liu, Yu Cui   +9 more
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Identification of a novel PHGDH covalent inhibitor by chemical proteomics and phenotypic profiling

Acta Pharmaceutica Sinica B, 2022
The first rate-limiting enzyme of the serine synthesis pathway (SSP), phosphoglycerate dehydrogenase (PHGDH), is hyperactive in multiple tumors, which leads to the activation of SSP and promotes tumorigenesis. However, only a few inhibitors of PHGDH have
Chen Chen, Tianyu Zhu, Xiaoqin Liu, Dongrong Zhu, Yi Zhang, Sifang Wu, Chao Han, Hao Zhang, Jianguang Luo, Lingyi Kong   +9 more
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Phosphoglycerate dehydrogenase positively regulates the proliferation of chicken muscle cells

Poultry Science, 2022
: Phosphoglycerate dehydrogenase (PHGDH) is the rate-limiting enzyme in the serine synthesis pathway. However, the regulatory role of PHGDH in muscle development is unclear.
Han Wang, Moran Hu, Zhaoxue Ding, Xiaolong Zhou, Songbai Yang, Zhonghao Shen, Feifei Yan, Ayong Zhao   +7 more
doaj   +1 more source