Results 101 to 110 of about 8,013 (194)

ZDHHC2‐Dependent Palmitoylation Dictates Ferroptosis and Castration Sensitivity in Prostate Cancer via Controlling ACSL4 Degradation and Lipid Peroxidation

Advanced Science, Volume 13, Issue 1, 5 January 2026.
Our study reveals a novel mechanism by which palmitoylation regulates ferroptosis and enzalutamide resistance in prostate cancer. Under enzalutamide resistance, the FOXA1/CXXC5/TET2 complex induces aberrant upregulation of ZDHHC2, which subsequently suppresses ferroptosis by mediating S‐palmitoylation of USP19 and degradation of ACSL4 protein in CRPC ...
Shuai Shao, Wei Li, Yulong Hong, Ruijiang Zeng, Liang Zhu, Lu Yi, Yuan Li, Yinhuai Wang, Haojie Huang, Xuewen Jiang, Xin Jin   +10 more
wiley   +1 more source

Genetic Variants Associated With Glycine Metabolism and Their Role in Insulin Sensitivity and Type 2 Diabetes [PDF]

, 2013
Circulating metabolites associated with insulin sensitivity may represent useful biomarkers, but their causal role in insulin sensitivity and diabetes is less certain.
Abbasi, F., Adam, K. P., Alkayyali, S., Assimes, T. L., Consortium, Diagram, Consortium, Genesis, Consortium, Risc, Dekker, J. M., Ferrannini, E., Frayling, T. M., Gall, W. E., Groop, L., Hansen, Torben, Haring, H., Investigators, Magic, Knowles, J. W., Laakso, M., Lyssenko, V., Nolan, J. J., Paananen, J., Pedersen, O., Quertermous, T., Smith, U., Walker, M., Weedon, M. N., Wood, A. R., Xie, W. J.   +26 more
core   +1 more source

Bioinformatics‐based discovery of the involvement of PSAT1 in mediating the anti‐lung adenocarcinoma activity of triptolide

Animal Models and Experimental Medicine, Volume 9, Issue 1, Page 115-127, January 2026.
Transcriptome sequencing was performed on tumor tissues from triptolide‐treated tumor‐bearing mice. The sequencing results were integrated with data from public databases for comprehensive analysis, and potential regulatory targets of triptolide were identified.
Zhiwen Cao, Lulu Zhang, Wenqiang Zhang, Rong Wan, Xiaogang Peng, Jinyan Xie, Ruru Bai, Jiejing Jin, Changqi Shi, Lan Yan, Xiangyu Guo, Yang Shen, Cheng Lu   +12 more
wiley   +1 more source

The impact of growth promoters on muscle growth and the potential consequences for meat quality [PDF]

, 2016
To meet the demands of increased global meat consumption, animal production systems will have to become more efficient, or at least maintain the current efficiency utilizing feed ingredients that are not also used for human consumption.
Aalhus, Adeola, Altarejos, Beermann, Beermann, Bodine, Bohorov, Boisclair, Brameld, Brameld, Brooke, Brown, Bush, Casas, Choe, Ciobanu, Clemmons, Coux, Cruzen, Daughaday, David M. Brown, Denley, Douillard, Duckett, Dunshea, Dunshea, Etherton, Etherton, FAO, Foresight, Fuentes-Prior, Geesink, Glass, Godfray, Goll, Goll, Goncalves, Gunawan, Hemmings, Henckel, Higgins, Hocquette, Hopkins, Houbak, Huang, Huang, John M. Brameld, Karlsson, Kemp, Kemp, Kevin J.P. Ryan, Kim, Kim, Koohmaraie, Koopman, Kretchmar, Krick, Krystal M. Hemmings, Lamare, Lametsch, Larzul, Lefaucheur, Liang, Mareko, Mareko, McNeel, Meersman, Mills, Molebeledi H.D. Mareko, Nonneman, Oksbjerg, Ouali, Page, Parr, Parr, Parr, Patience, Peters, Renand, Robert, Ryan, Ryu, Schiaffino, Sensky, Sentandreu, Seppelt, Siegel, Solomon, Taillandier, Tang, Taylor, Taylor, Tim Parr, Tomas, Underwood, Vann, Velloso, Wang, Wendt, Wheeler, Whipple, White   +101 more
core   +1 more source

Nuclear PHGDH regulates macrophage polarization through transcriptional repression of GLUD1 and GLS2 in breast cancer

Cancer Biology & Medicine
Objective: Tumor-associated macrophages (TAMs) exhibit heterogeneous properties including anti-tumorigenic and pro-tumorigenic phenotypes. The rate-limiting enzyme in de novo serine biosynthesis, 3-phosphoglycerate dehydrogenase (PHGDH), has a well ...
Pei Wang, Xin Du, Zhiren Han, Jiaxin Zhong, Jiayu Yuan, Lin Jiang, Beinan Han, Wenkui Fu, Hongde Li, Hai Hu, Zhenkun Na   +10 more
doaj   +1 more source

Metabolism‐Regulating Nanomedicines for Cancer Therapy

Advanced NanoBiomed Research, Volume 6, Issue 1, January 2026.
This review highlights metabolism‐regulating nanomedicines designed to target glycolytic, lipid, amino acid, and nucleotide pathways in tumors. By incorporating metabolism‐regulating agents into versatile nanocarriers such as liposomes, micelles, dendrimers, and engineered bacteria, these platforms achieve targeted delivery, controlled release ...
Xiao Wu, Shiyi Geng, Jian Yang
wiley   +1 more source

Cancer Metabolism: A Modeling Perspective [PDF]

, 2015
Tumor cells alter their metabolism to maintain unregulated cellular proliferation and survival, but this transformation leaves them reliant on constant supply of nutrients and energy.
Ghaffari, Pouyan, Mardinoglu, Adil, Nielsen, Jens   +2 more
core   +1 more source

A Nonketotic Hyperglycinemia Mouse Shows Wide‐Ranging Biochemical Consequences of Elevated Glycine, Reduced Folate One‐Carbon Charging, and Serine Deficiency

Journal of Inherited Metabolic Disease, Volume 49, Issue 1, January 2026.
ABSTRACT Nonketotic hyperglycinemia is a severe neonatal epileptic encephalopathy caused by deficient glycine cleavage enzyme activity, for which currently no effective treatment exists. Incomplete understanding of brain biochemistry represents a major knowledge gap to develop new treatments.
Michael A. Swanson, Hua Jiang, Lakshmi Divya Kolora, Rachel Molino, Richard Reisdorph, Cole R. Michel, Katrina A. Doenges, Kit‐Yi Leung, Xiangping Lin, Frank Wong, Samual Lancaster, Basil Michael, Michael Snyder, Daniella H. Hock, David A. Stroud, Tim Wood, Robert Binard, Laura Anderson‐Lehman, Uwe Christians, Erland Arning, Marisa W. Friederich, Roxanne A. Van Hove, Kenneth N. MacLean, Nicholas D. E. Greene, Johan L. K. Van Hove   +24 more
wiley   +1 more source

Genetic variants including markers from the exome chip and metabolite traits of type 2 diabetes [PDF]

, 2017
Diabetes-associated metabolites may aid the identification of new risk variants for type 2 diabetes. Using targeted metabolomics within a subsample of the German EPIC-Potsdam study (n = 2500), we tested previously published SNPs for their association ...
Floegel, Anna, Hoffmann, Per, Jäger, Susanne, Kröger, Janine, Pischon, Tobias, Prehn, Cornelia [u.a.], Sharma, Sapna, Wahl, Simone   +7 more
core   +1 more source

Melanoma: Pathogenesis and Targeted Therapy

MedComm, Volume 7, Issue 1, January 2026.
The treatment landscape for advanced melanoma has evolved significantly. BRAF–MEK inhibitor combinations are standard for BRAF‐mutant melanoma, whereas targeting NRAS mutations is more challenging, with MEK inhibitors like tunlametinib emerging as an option.
Yang Fu, Jie Liu, Zeming Mo, Bin Wang, Yaotiao Deng, Yu Jiang   +5 more
wiley   +1 more source