Results 101 to 110 of about 8,290 (226)

α-Ketothioamide Derivatives: A Promising Tool to Interrogate Phosphoglycerate Dehydrogenase (PHGDH) [PDF]

Journal of Medicinal Chemistry, 2017
Given the putative role of PHGDH in cancer, development of inhibitors is required to explore its function. In this context, we established and validated a straightforward enzymatic assay suitable for high-throughput screening and we identified inhibitors with similar chemical scaffolds.
Séverine Ravez, Cyril Corbet, Quentin Spillier, Alice Dutu, Anita D. Robin, Edouard Mullarky, Lewis C. Cantley, Olivier Feron, Raphaël Frédérick   +8 more
openaire   +2 more sources

Identification and characterization of dysregulated P-element induced wimpy testis-interacting RNAs in head and neck squamous cell carcinoma. [PDF]

, 2019
It is clear that alcohol consumption is a major risk factor in the pathogenesis of head and neck squamous cell carcinoma (HNSCC); however, the molecular mechanism underlying the pathogenesis of alcohol-associated HNSCC remains poorly understood.
Ku, Jonjei, Kuo, Selena Z, Li, Pin Xue, Ongkeko, Weg M, Saad, Maarouf A, Wang-Rodriguez, Jessica, Yu, Michael Andrew, Zheng, Hao   +7 more
core  

Expanding the concepts and tools of metabolic engineering to elucidate cancer metabolism [PDF]

, 2012
The metabolic engineer's toolbox, comprising stable isotope tracers, flux estimation and analysis, pathway identification, and pathway kinetics and regulation, among other techniques, has long been used to elucidate and quantify pathways primarily in the
Fendt, Sarah-Maria, Keibler, Mark Andrew, Stephanopoulos, Gregory   +2 more
core   +1 more source

Melanoma: Pathogenesis and Targeted Therapy

MedComm, Volume 7, Issue 1, January 2026.
The treatment landscape for advanced melanoma has evolved significantly. BRAF–MEK inhibitor combinations are standard for BRAF‐mutant melanoma, whereas targeting NRAS mutations is more challenging, with MEK inhibitors like tunlametinib emerging as an option.
Yang Fu, Jie Liu, Zeming Mo, Bin Wang, Yaotiao Deng, Yu Jiang   +5 more
wiley   +1 more source

Cancer Metabolism: A Modeling Perspective [PDF]

, 2015
Tumor cells alter their metabolism to maintain unregulated cellular proliferation and survival, but this transformation leaves them reliant on constant supply of nutrients and energy.
Ghaffari, Pouyan, Mardinoglu, Adil, Nielsen, Jens   +2 more
core   +1 more source

The impact of growth promoters on muscle growth and the potential consequences for meat quality [PDF]

, 2016
To meet the demands of increased global meat consumption, animal production systems will have to become more efficient, or at least maintain the current efficiency utilizing feed ingredients that are not also used for human consumption.
Aalhus, Adeola, Altarejos, Beermann, Beermann, Bodine, Bohorov, Boisclair, Brameld, Brameld, Brooke, Brown, Bush, Casas, Choe, Ciobanu, Clemmons, Coux, Cruzen, Daughaday, David M. Brown, Denley, Douillard, Duckett, Dunshea, Dunshea, Etherton, Etherton, FAO, Foresight, Fuentes-Prior, Geesink, Glass, Godfray, Goll, Goll, Goncalves, Gunawan, Hemmings, Henckel, Higgins, Hocquette, Hopkins, Houbak, Huang, Huang, John M. Brameld, Karlsson, Kemp, Kemp, Kevin J.P. Ryan, Kim, Kim, Koohmaraie, Koopman, Kretchmar, Krick, Krystal M. Hemmings, Lamare, Lametsch, Larzul, Lefaucheur, Liang, Mareko, Mareko, McNeel, Meersman, Mills, Molebeledi H.D. Mareko, Nonneman, Oksbjerg, Ouali, Page, Parr, Parr, Parr, Patience, Peters, Renand, Robert, Ryan, Ryu, Schiaffino, Sensky, Sentandreu, Seppelt, Siegel, Solomon, Taillandier, Tang, Taylor, Taylor, Tim Parr, Tomas, Underwood, Vann, Velloso, Wang, Wendt, Wheeler, Whipple, White   +101 more
core   +1 more source

Skullcapflavone II Inhibits SLC1A4‐Mediated L‐Serine Uptake and Promotes Mitochondrial Damage in Gastric Cancer

Advanced Science, Volume 12, Issue 45, December 4, 2025.
Skullcapflavone II (SkII) significantly alters serine metabolism in gastric cancer cells by directly targeting the L‐serine transporter SLC1A4, thereby inhibiting L‐serine uptake rather than de novo synthesis. This disruption of serine metabolism by SkII leads to increased oxidative stress and consequent mitochondrial damage.
Jing Zhao, Yu‐Bo Ma, Rui‐Hong Xia, Zheng‐Chen Jiang, Ying Zhou, Ya‐Nan Wang, Meng‐Yan Yang, Jing‐Jie Dai, Tao Zhu, Li‐Bin Pan, Li Yuan   +10 more
wiley   +1 more source

Renal UTX-PHGDH-serine axis regulates metabolic disorders in the kidney and liver [PDF]

, 2022
Hong Chen, Chong Liu, Qian Wang, Mingrui Xiong, Xia Zeng, Dong Yang, Yunhao Xie, Hua Su, Yu Zhang, Yixue Huang, Yuchen Chen, Junqiu Yue, Chengyu Liu, Shun Wang, Kun Huang, Ling Zheng   +15 more
openalex   +1 more source

New molecular mechanisms in cholangiocarcinoma: signals triggering interleukin-6 production in tumor cells and KRAS co-opted epigenetic mediators driving metabolic reprogramming

Journal of Experimental & Clinical Cancer Research, 2022
Background Cholangiocarcinoma (CCA) is still a deadly tumour. Histological and molecular aspects of thioacetamide (TAA)-induced intrahepatic CCA (iCCA) in rats mimic those of human iCCA.
Leticia Colyn, Gloria Alvarez-Sola, M. Ujue Latasa, Iker Uriarte, Jose M. Herranz, Maria Arechederra, George Vlachogiannis, Colin Rae, Antonio Pineda-Lucena, Andrea Casadei-Gardini, Federica Pedica, Luca Aldrighetti, Angeles López-López, Angeles López-Gonzálvez, Coral Barbas, Sergio Ciordia, Sebastiaan M. Van Liempd, Juan M. Falcón-Pérez, Jesus Urman, Bruno Sangro, Silve Vicent, Maria J. Iraburu, Felipe Prosper, Leonard J. Nelson, Jesus M. Banales, Maria Luz Martinez-Chantar, Jose J. G. Marin, Chiara Braconi, Christian Trautwein, Fernando J. Corrales, F. Javier Cubero, Carmen Berasain, Maite G. Fernandez-Barrena, Matias A. Avila   +33 more
doaj   +1 more source

Phosphoserine aminotransferase 1 is associated to poor outcome on tamoxifen therapy in recurrent breast cancer [PDF]

, 2017
In a previous study, we detected a significant association between phosphoserine aminotransferase 1 (PSAT1) hyper-methylation and mRNA levels to outcome to tamoxifen treatment in recurrent disease.
Deurzen, C.H.M. (Carolien) van, Foekens, J.A. (John), Grebenchtchikov, N. (Nicolai), Look, M.P. (Maxime), Magdolen, V., Marchi, T. (Tommaso) de, Martens, J.W.M. (John), Sieuwerts, A.M. (Anieta), Smid, M. (Marcel), Smits, J.G. (Jan G.), Sweep, F.C. (Fred), Timmermans, A.M. (Mieke), Umar, A. (Arzu)   +12 more
core   +1 more source