Results 111 to 120 of about 8,013 (194)

The 2014 Beatson International Cancer Conference: Powering the Cancer Machine [PDF]

, 2014
Here, we present a report of the 2014 annual Beatson International Cancer Conference, Glasgow, July 6–9, 2014. The theme was “Powering the Cancer Machine”, focusing on oncogenic signals that regulate metabolic rewiring and the adaptability of the ...
Daniel J Murphy, Jurre J Kamphorst
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YY2 mediates transcriptional repression of PHGDH and expedites oxidative stress in retinal pigment epithelial cells in diabetic retinopathy

Journal of Diabetes Investigation
Aims/Introduction Phosphoglycerate dehydrogenase (PHGDH), which controls serine synthesis, has been linked to retinal disease. However, there are no clues about its involvement in the diabetic retinopathy (DR) progression.
Xiang Lei, Xiu Wang, Xinai Zhang
doaj   +1 more source

PHGDH as a therapeutic node: Natural modulators from TCM, degradation pathways, and emerging TPD strategies

Pharmacological Research
Phosphoglycerate dehydrogenase (PHGDH) has emerged as a promising therapeutic target due to its critical roles in the pathogenesis of cancer and neurological disorders.
Song-Song Shi, Yu-Dan Du, Si-Yi Chen, Wen Zhang, Guo-Wu Rao, Quan Zheng   +5 more
doaj   +1 more source

Phosphoserine aminotransferase 1 is associated to poor outcome on tamoxifen therapy in recurrent breast cancer [PDF]

, 2017
In a previous study, we detected a significant association between phosphoserine aminotransferase 1 (PSAT1) hyper-methylation and mRNA levels to outcome to tamoxifen treatment in recurrent disease.
Deurzen, C.H.M. (Carolien) van, Foekens, J.A. (John), Grebenchtchikov, N. (Nicolai), Look, M.P. (Maxime), Magdolen, V., Marchi, T. (Tommaso) de, Martens, J.W.M. (John), Sieuwerts, A.M. (Anieta), Smid, M. (Marcel), Smits, J.G. (Jan G.), Sweep, F.C. (Fred), Timmermans, A.M. (Mieke), Umar, A. (Arzu)   +12 more
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Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK [PDF]

, 2017
葡萄糖是生物中最基本、最主要的营养物质，它不仅是机体能量的主要来源，也是生物质合成的主要原料。因此，葡萄糖的水平对于生物体是极其重要的。然而，在生活中，体内葡萄糖水平的波动是十分常见的，这是因为我们不可能每时每刻都在摄入葡萄糖：睡一大觉、剧烈运动几个小时或者太忙了没时间吃饭，都会引起葡萄糖水平的显著下降。这时，机体能够触发一套有效的过程应对这类“不利情况”，其中最为关键的就是激活“代谢的核心调节”——AMPK。在葡萄糖水平下降时，被激活的AMPK能够迅速启动脂肪、蛋白质的分解代谢，关闭它们的合成代谢 ...
A Sols, AJ Morris, Alexander Gray, AW Kao, B Xiao, B Xiao, C Ritterson Lew, CG Langendorf, Chen-Song Zhang, CS Zhang, D Carling, D. Grahame Hardie, F Rago, FA Ran, FA Ross, G Kroemer, GR Steinberg, H Hu, Hai-Long Piao, Huiyong Yin, IP Salt, Jin-Wei Feng, Jiwen Cui, JS Oakhill, JW Dennis, KH Choi, L Alvarez-Erviti, M Forgac, M Lu, M Lu, M Lu, Mengqi Li, Mingjiang Zhu, MM Mihaylova, MR El-Maghrabi, PM Kelley, SA Hawley, Sheng-Cai Lin, Shu-Yong Lin, Simon A. Hawley, SV Costes, Teng Ma, Terytty Yang Li, TY Li, VP Houde, WA Wilson, Y Zhao, YL Zhang, Yu-Qing Wu, Yue Zong, Zhichao Wang, Zhiyun Ye   +51 more
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Metabolomic changes during cellular transformation monitored by metabolite-metabolite correlation analysis and correlated with gene expression. [PDF]

, 2015
To investigate metabolic changes during cellular transformation, we used a 1H NMR based metabolite-metabolite correlation analysis (MMCA) method, which permits analysis of homeostatic mechanisms in cells at the steady state, in an inducible cell ...
Griffiths, John R, Jauhiainen, Alexandra, Madhu, Basetti, Menon, Suraj, Narita, Masako, Narita, Masashi, Stubbs, Marion, Tavaré, Simon   +7 more
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eIF1 modulates the recognition of suboptimal translation initiation sites and steers gene expression via uORFs [PDF]

, 2017
Alternative translation initiation mechanisms such as leaky scanning and reinitiation potentiate the polycistronic nature of human transcripts. By allowing for reprogrammed translation, these mechanisms can mediate biological responses to stimuli.
Fijalkowska, Daria, Jonckheere, Veronique, Menschaert, Gerben, Ndah, Elvis, Van Damme, Petra, Verbruggen, Steven   +5 more
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Local lung hypoxia determines epithelial fate decisions during alveolar regeneration. [PDF]

, 2017
After influenza infection, lineage-negative epithelial progenitors (LNEPs) exhibit a binary response to reconstitute epithelial barriers: activating a Notch-dependent ΔNp63/cytokeratin 5 (Krt5) remodelling program or differentiating into alveolar type II
Brumwell, Alexis N, Chapman, Harold A, Driver, Ian H, Gotts, Jeffrey E, Jackson, Julia R, Kim, Thomas, Lee, Dong-Kee, Matthay, Michael A, Shannon, John M, Tan, Victor, Vaughan, Andrew E, Wei, Ying, Xi, Ying, Xu, Jianming   +13 more
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Therapeutic arginine starvation in ASS1-deficient cancers inhibits the Warburg effect

Molecular & Cellular Oncology, 2017
Argininosuccinate Synthetase 1 deficiency induces dependence on extracellular arginine for continued cellular growth and survival. Arginine starvation inhibits the Warburg effect and diverts glucose into serine biosynthesis, while simultaneously ...
Jeff C. Kremer, Brian A. Van Tine
doaj   +1 more source

Transcriptional regulation by PHGDH drives amyloid pathology in Alzheimer’s disease

Cell
Virtually all individuals aged 65 or older develop at least early pathology of Alzheimer's disease (AD), yet most lack disease-causing mutations in APP, PSEN, or MAPT, and many do not carry the APOE4 risk allele. This raises questions about AD development in the general population.
Junchen Chen, Fatemeh Hadi, Xingzhao Wen, Wenxin Zhao, Ming Xu, Shuanghong Xue, Pei Lin, Riccardo Calandrelli, John Lalith Charles Richard, Zhixuan Song, Jessica Li, Alborz Amani, Yang Liu, Xu Chen, Sheng Zhong   +14 more
openaire   +3 more sources