Results 111 to 120 of about 8,290 (226)
Cancer Communications, Volume 45, Issue 12, Page 1706-1733, December 2025.Abstract Background Metastasis is the leading cause of cancer‐related mortality, with circulating tumor cell (CTC) clusters serving as highly efficient precursors of distant metastasis. Survival of CTC clusters in the bloodstream is the primary contributor to tumor metastasis.
Rui Tang +12 more
wiley +1 more source
Genetic variants including markers from the exome chip and metabolite traits of type 2 diabetes [PDF]
, 2017 Diabetes-associated metabolites may aid the identification of new risk variants for type 2 diabetes. Using targeted metabolomics within a subsample of the German EPIC-Potsdam study (n = 2500), we tested previously published SNPs for their association ...
Floegel, Anna +7 more
core +1 more source
MedComm, Volume 6, Issue 12, December 2025.Lung cancer represents a significant global health threat. Despite progress in treatment, metastasis continues to present a major clinical challenge. This article reviews the metastases of lung cancer to the liver, bone, and brain, focusing on clinical symptoms, molecular mechanisms, and treatment strategies.
Yunkui Zhang +4 more
wiley +1 more source
MedComm, Volume 6, Issue 12, December 2025.Protein arginine methyltransferase 1 (PRMT1) is a pivotal enzyme that catalyzes the asymmetric dimethylation of arginine residues, thereby functioning as a critical epigenetic regulator of diverse biological processes such as gene expression, RNA splicing, and DNA repair.
Yanqun Luo +4 more
wiley +1 more source
The 2014 Beatson International Cancer Conference: Powering the Cancer Machine [PDF]
, 2014 Here, we present a report of the 2014 annual Beatson International Cancer Conference, Glasgow, July 6–9, 2014. The theme was “Powering the Cancer Machine”, focusing on oncogenic signals that regulate metabolic rewiring and the adaptability of the ...
Daniel J Murphy, Jurre J Kamphorst
core +1 more source
MedComm, Volume 6, Issue 12, December 2025.Cancer is a complex tumor system consisting of tumor cells, immune effector cells, and all the matrix components. The intricate interactions among cells and molecular signaling pathways in this microenvironment jointly drive tumor growth, invasion, and metastasis, and significantly influence the efficacy of cancer treatment. Meanwhile, the treatment of
Ying Sun +11 more
wiley +1 more source
Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK [PDF]
, 2017 葡萄糖是生物中最基本、最主要的营养物质，它不仅是机体能量的主要来源，也是生物质合成的主要原料。因此，葡萄糖的水平对于生物体是极其重要的。然而，在生活中，体内葡萄糖水平的波动是十分常见的，这是因为我们不可能每时每刻都在摄入葡萄糖：睡一大觉、剧烈运动几个小时或者太忙了没时间吃饭，都会引起葡萄糖水平的显著下降。这时，机体能够触发一套有效的过程应对这类“不利情况”，其中最为关键的就是激活“代谢的核心调节”——AMPK。在葡萄糖水平下降时，被激活的AMPK能够迅速启动脂肪、蛋白质的分解代谢，关闭它们的合成代谢 ...
A Sols +51 more
core +2 more sources
Molecular Nutrition &Food Research, Volume 69, Issue 24, December 2025.Nuts and legumes contain both nutrients and bioactive compounds supporting cardiovascular health related to influencing DNA methylation. These foods are related to reducing oxidative stress, supplying methyl donors, and modulating genes involved in platelet function, such as PEAR1 and mitochondrial genes, in association with helping reduce inflammation
Siwaphorn Chaimati +2 more
wiley +1 more source
Genetic Variants Associated With Glycine Metabolism and Their Role in Insulin Sensitivity and Type 2 Diabetes [PDF]
, 2013 Circulating metabolites associated with insulin sensitivity may represent useful biomarkers, but their causal role in insulin sensitivity and diabetes is less certain.
Abbasi, F. +26 more
core +1 more source
Metabolomic changes during cellular transformation monitored by metabolite-metabolite correlation analysis and correlated with gene expression. [PDF]
, 2015 To investigate metabolic changes during cellular transformation, we used a 1H NMR based metabolite-metabolite correlation analysis (MMCA) method, which permits analysis of homeostatic mechanisms in cells at the steady state, in an inducible cell ...
Griffiths, John R +7 more
core +2 more sources