Results 11 to 20 of about 8,721 (232)

Elevated Nuclear PHGDH Synergistically Functions with cMyc to Reshape the Immune Microenvironment of Liver Cancer

Advanced Science, 2023
Herein, we observed that nuclear localization of phosphoglycerate dehydrogenase (PHGDH) is associated with poor prognosis in liver cancer, and Phgdh is required for liver cancer progression in a mouse model.
Hongwen Zhu, Hua Yu, Hu Zhou, Wencheng Zhu, Xiongjun Wang   +4 more
semanticscholar   +2 more sources

YY2 mediates transcriptional repression of PHGDH and expedites oxidative stress in retinal pigment epithelial cells in diabetic retinopathy. [PDF]

J Diabetes Investig
Aims/Introduction Phosphoglycerate dehydrogenase (PHGDH), which controls serine synthesis, has been linked to retinal disease. However, there are no clues about its involvement in the diabetic retinopathy (DR) progression.
Lei X, Wang X, Zhang X.
europepmc   +4 more sources

Multi-omics Analysis of the Role of PHGDH in Colon Cancer

Technology in Cancer Research & Treatment, 2023
Objectives: Serine metabolism is essential for tumor cells. Endogenous serine arises from de novo synthesis pathways. As the rate-limiting enzyme of this pathway, PHGDH is highly expressed in a variety of tumors including colon cancer.
Zhihui Dai, Lin Chen, Kailing Pan, Xiaoya Zhao, Wenxia Xu, Jinlin Du, C. Xing   +6 more
semanticscholar   +2 more sources

Comprehensive analysis of PHGDH for predicting prognosis and immunotherapy response in patients with endometrial carcinoma

BMC Medical Genomics, 2023
Background PHGDH (Phosphoglycerate Dehydrogenase) is the first branch enzyme in the serine biosynthetic pathway and plays a vital role in several cancers. However, little is known about the clinical significance of PHGDH in endometrial cancer.
He Zhang, W. Kong, Xiaoling Zhao, Yunkai Xie, Dan Luo, Shuning Chen   +5 more
semanticscholar   +2 more sources

PHGDH: a novel therapeutic target in cancer

Experimental and Molecular Medicine
Serine is a key contributor to the generation of one-carbon units for DNA synthesis during cellular proliferation. In addition, it plays a crucial role in the production of antioxidants that prevent abnormal proliferation and stress in cancer cells.
Chae Min Lee, Yeseong Hwang, Minki Kim, Ye-Chan Park, Hyeonhui Kim, Sungsoon Fang   +5 more
semanticscholar   +2 more sources

ASS1 inhibits triple-negative breast cancer by regulating PHGDH stability and de novo serine synthesis

Cell Death and Disease
Argininosuccinate synthase (ASS1), a critical enzyme in the urea cycle, acts as a tumor suppressor in many cancers. To date, the anticancer mechanism of ASS1 has not been fully elucidated. Here, we found that phosphoglycerate dehydrogenase (PHGDH), a key
Wensong Luo, Zizheng Zou, Yuan Nie, Junli Luo, Zhengnan Ming, Xiyuan Hu, Tiao Luo, Ouyang Min, Mingquan Liu, Huicheng Tang, Yuanzhu Xie, Kunjian Peng, Ling Chen, Jiang Zhou, Zhiyong Luo   +14 more
semanticscholar   +2 more sources

Classical swine fever virus inhibits serine metabolism-mediated antiviral immunity by deacetylating modified PHGDH

mBio
Classical swine fever virus (CSFV), an obligate intracellular pathogen, hijacks cellular metabolism to evade immune surveillance and facilitate its replication. The precise mechanisms by which CSFV modulates immune metabolism remain largely unknown.
Xiaowen Li, Yaoyao Huang, Xueyi Liu, Lihong Zhang, Xinyan Wang, Feifan Zhao, L. Zou, Keke Wu, Wenxian Chen, Yuwei Qin, S. Zeng, Bingke Li, Yintao He, Yiwan Song, Zhaoyao Li, Jindai Fan, Mingqiu Zhao, Lin Yi, Hongxing Ding, Shuangqi Fan, Jinding Chen   +20 more
semanticscholar   +3 more sources

Unravelling the Allosteric Targeting of PHGDH at the ACT-Binding Domain with a Photoactivatable Diazirine Probe and Mass Spectrometry Experiments [PDF]

Molecules, 2021
The serine biosynthetic pathway is a key element contributing to tumor proliferation. In recent years, targeting of phosphoglycerate dehydrogenase (PHGDH), the first enzyme of this pathway, intensified and revealed to be a promising strategy to develop ...
Quentin Spillier, Séverine Ravez, Simon Dochain, Didier Vertommen, Léopold Thabault, Olivier Féron, Raphaël Frédérick   +6 more
openalex   +3 more sources

PHGDH drives 5-FU chemoresistance in colorectal cancer through the Hedgehog signaling. [PDF]

J Exp Clin Cancer Res
Background Phosphoglycerate dehydrogenase (PHGDH) is the rate-limiting enzyme in the de novo Serine synthesis pathway (SSP), a highly regulated pathway overexpressed in several tumors.
Mancini C, Lori G, Mattei G, Iozzo M, Desideri D, Cianchi F, Fortuna L, Passagnoli F, Massi D, Ugolini F, Messerini L, Piscuoglio S, Pezone A, Magherini F, Biagioni A, Lottini T, Zambardino D, Truglio GI, Petricci E, Magi A, Arcangeli A, Maresca L, Stecca B, Pranzini E, Taddei ML.   +24 more
europepmc   +2 more sources

Hsa_circ_0062682 Promotes Serine Metabolism and Tumor Growth in Colorectal Cancer by Regulating the miR-940/PHGDH Axis

Frontiers in Cell and Developmental Biology, 2021
Colorectal cancer (CRC) is one of the most common malignancies globally. Increasing evidence indicates that circular RNAs (circRNAs) play a pivotal role in various cancers. The present study focused on exploring the role of a functionally unknown circRNA,
Shengbai Sun, Chaoqun Li, Kaisa Cui, Bingxin Liu, Mingyue Zhou, Yulin Cao, Jia Zhang, Zehua Bian, Bojian Fei, Zhaohui Huang   +9 more
doaj   +4 more sources