PHGDH supports liver ceramide synthesis and sustains lipid homeostasis [PDF]
Cancer & Metabolism, 2020 Background d-3-phosphoglycerate dehydrogenase (PHGDH), which encodes the first enzyme in serine biosynthesis, is overexpressed in human cancers and has been proposed as a drug target.
Yun Pyo Kang +8 more
doaj +4 more sources
Increased PHGDH expression promotes aberrant melanin accumulation [PDF]
BMC Cancer, 2019 Background Copy number gain of the D-3-phosphoglycerate dehydrogenase (PHGDH) gene, which encodes the first enzyme in serine biosynthesis, is found in some human cancers including a subset of melanomas.
Katherine R. Mattaini +5 more
doaj +3 more sources
Macrophage-specific PHGDH protects against MAFLD by suppressing TAK1
Cell ReportsSummary: Metabolic dysfunction-associated fatty liver disease (MAFLD) is a progressive disease with only one approved treatment currently available.
Penghui Hu +16 more
doaj +3 more sources
Molecular glue triggers degradation of PHGDH by enhancing the interaction between DDB1 and PHGDH
Acta Pharmaceutica Sinica BCancer stem cells (CSCs) play a pivotal role in tumor initiation, proliferation, metastasis, drug resistance, and recurrence. Consequently, targeting CSCs has emerged as a promising avenue for cancer therapy.
Ziqi Huang +16 more
doaj +3 more sources
ZEB1 Transcriptionally Activates PHGDH to Facilitate Carcinogenesis and Progression of HCCSummary
Cellular and Molecular Gastroenterology and Hepatology, 2023 Background & Aims: Phosphoglycerate dehydrogenase (PHGDH), the rate-limiting enzyme of the de novo serine synthesis pathway (SSP), has been implicated in the carcinogenesis and metastasis of hepatocellular carcinoma (HCC) because of its excessive ...
Huihui Wang +15 more
doaj +3 more sources
PHGDH: a novel therapeutic target in cancer
Experimental and Molecular MedicineSerine is a key contributor to the generation of one-carbon units for DNA synthesis during cellular proliferation. In addition, it plays a crucial role in the production of antioxidants that prevent abnormal proliferation and stress in cancer cells.
Chae Min Lee +5 more
doaj +3 more sources
Increased Expression of PHGDH and Prognostic Significance in Colorectal Cancer
Translational Oncology, 2016 Phosphoglycerate dehydrogenase (PHGDH) plays an essential role in cancer-specific metabolic reprogramming. It has been reported as a putative metabolic oncogene in several types of human malignant tumors, such as breast cancer and melanoma.
Xiao-qin Jia +6 more
doaj +3 more sources
Post-translational regulation of human D-3-phosphoglycerate dehydrogenase in Alzheimer's disease. [PDF]
Protein SciAbstract Emerging evidence suggests that sex‐specific differences in L‐serine (L‐Ser) metabolism play a key role in Alzheimer's disease (AD). While disruptions in amino acid balance are well known, recent findings point to a dimorphic regulation of the serine biosynthetic pathway.
Zerbini E +5 more
europepmc +2 more sources
PHGDH inhibition and FOXO3 modulation drives PUMA-dependent apoptosis in osteosarcoma
Cell Death and DiseaseOsteosarcoma is a bone cancer that has been found to be metabolically dependent on the conversion of glucose to serine through the rate-limiting enzyme 3-phosphoglycerate dehydrogenase (PHGDH).
Toshinao Oyama +7 more
doaj +3 more sources
PHGDH Defines a Metabolic Subtype in Lung Adenocarcinomas with Poor Prognosis [PDF]
Cell Reports, 2017 Molecular signatures are emerging determinants of choice of therapy for lung adenocarcinomas. An evolving therapeutic approach includes targeting metabolic dependencies in cancers.
Boxi Zhang +7 more
doaj +3 more sources