Results 11 to 20 of about 8,290 (226)
Increased PHGDH expression promotes aberrant melanin accumulation [PDF]
BMC Cancer, 2019 Background Copy number gain of the D-3-phosphoglycerate dehydrogenase (PHGDH) gene, which encodes the first enzyme in serine biosynthesis, is found in some human cancers including a subset of melanomas.
Katherine R. Mattaini +5 more
doaj +5 more sources
PHGDH inhibition and FOXO3 modulation drives PUMA-dependent apoptosis in osteosarcoma [PDF]
Cell Death and DiseaseOsteosarcoma is a bone cancer that has been found to be metabolically dependent on the conversion of glucose to serine through the rate-limiting enzyme 3-phosphoglycerate dehydrogenase (PHGDH).
Toshinao Oyama +7 more
doaj +4 more sources
PHGDH heterogeneity potentiates cancer cell dissemination and metastasis [PDF]
Nature, 2022 Cancer metastasis requires the transient activation of cellular programs enabling dissemination and seeding in distant organs1. Genetic, transcriptional and translational heterogeneity contributes to this dynamic process2,3. Metabolic heterogeneity has also been observed4, yet its role in cancer progression is less explored.
Matteo Rossi +50 more
openalex +7 more sources
Nuclear PHGDH protects cancer cells from nutrient stress
Nature Metabolism, 2021 In this study, the serine biosynthetic enzyme PHGDH is shown to transition from the cytosol to the nucleus following nutrient stress. Nuclear PHGDH reduces local NAD+ availability needed for the PARylation of the transcription factor c-Jun. Consequently, c-Jun activity is reduced, contributing to sustained cancer cell proliferation.
Daniela Annibali, Sarah‐Maria Fendt
openalex +5 more sources
PHGDH supports liver ceramide synthesis and sustains lipid homeostasis [PDF]
Cancer & Metabolism, 2020 Background d-3-phosphoglycerate dehydrogenase (PHGDH), which encodes the first enzyme in serine biosynthesis, is overexpressed in human cancers and has been proposed as a drug target.
Yun Pyo Kang +8 more
doaj +4 more sources
PHGDH as a mechanism for resistance in metabolically-driven cancers
Cancer Drug Resistance, 2020 At the forefront of cancer research is the rapidly evolving understanding of metabolic reprogramming within cancer cells. The expeditious adaptation to metabolic inhibition allows cells to evolve and acquire resistance to targeted treatments, which makes therapeutic exploitation complex but achievable.
Richa Rathore +2 more
openalex +4 more sources
Multi-omics Analysis of the Role of PHGDH in Colon Cancer
Technology in Cancer Research & Treatment, 2023 Objectives : Serine metabolism is essential for tumor cells. Endogenous serine arises from de novo synthesis pathways. As the rate-limiting enzyme of this pathway, PHGDH is highly expressed in a variety of tumors including colon cancer.
Zhihui Dai MSc +6 more
doaj +3 more sources
Macrophage-specific PHGDH protects against MAFLD by suppressing TAK1
Cell ReportsSummary: Metabolic dysfunction-associated fatty liver disease (MAFLD) is a progressive disease with only one approved treatment currently available.
Penghui Hu +16 more
doaj +3 more sources
Frontiers in Oncology, 2021 BackgroundPlatinum-based chemotherapy is the first line option for ovarian cancer. The development of resistance to such chemotherapy results in treatment failure, while the underlying mechanisms are poorly understood.MethodsClinical samples were ...
Fangfang Bi +4 more
doaj +2 more sources
PHGDH expression increases with progression of Alzheimer’s disease pathology and symptoms
Cell Metabolism, 2022 Chen et al. reveal an increase of phosphoglycerate dehydrogenase (PHGDH) mRNA and protein levels in two mouse models and four human cohorts in Alzheimer's disease brains compared to age- and sex-matched control brains. The increase of PHGDH expression in human brain correlates with symptomatic development and disease pathology.
Xu Chen +7 more
openalex +5 more sources