Molecular glue triggers degradation of PHGDH by enhancing the interaction between DDB1 and PHGDH
Acta Pharmaceutica Sinica BCancer stem cells (CSCs) play a pivotal role in tumor initiation, proliferation, metastasis, drug resistance, and recurrence. Consequently, targeting CSCs has emerged as a promising avenue for cancer therapy.
Ziqi Huang +16 more
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ZEB1 Transcriptionally Activates PHGDH to Facilitate Carcinogenesis and Progression of HCCSummary
Cellular and Molecular Gastroenterology and Hepatology, 2023 Background & Aims: Phosphoglycerate dehydrogenase (PHGDH), the rate-limiting enzyme of the de novo serine synthesis pathway (SSP), has been implicated in the carcinogenesis and metastasis of hepatocellular carcinoma (HCC) because of its excessive ...
Huihui Wang +15 more
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Increased Expression of PHGDH and Prognostic Significance in Colorectal Cancer
Translational Oncology, 2016 Phosphoglycerate dehydrogenase (PHGDH) plays an essential role in cancer-specific metabolic reprogramming. It has been reported as a putative metabolic oncogene in several types of human malignant tumors, such as breast cancer and melanoma.
Xiao-qin Jia +6 more
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PHGDH: a novel therapeutic target in cancer
Experimental and Molecular MedicineSerine is a key contributor to the generation of one-carbon units for DNA synthesis during cellular proliferation. In addition, it plays a crucial role in the production of antioxidants that prevent abnormal proliferation and stress in cancer cells.
Chae Min Lee +5 more
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Down regulating PHGDH affects the lactate production of sertoli cells in varicocele [PDF]
Reproductive Biology and Endocrinology, 2020 Background Although varicocele is considered to be one of the leading causes of male infertility, the precise mechanism underlying how varicocele leads to male infertility is not completely understood. We found the lactate concentration on the varicocele
Wen-bin Guo +10 more
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Structure–Activity Relationships (SARs) of α-Ketothioamides as Inhibitors of Phosphoglycerate Dehydrogenase (PHGDH) [PDF]
Pharmaceuticals, 2020 For many years now, targeting deregulation within cancer cells’ metabolism has appeared as a promising strategy for the development of more specific and efficient cancer treatments.
Quentin Spillier +6 more
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An idle PHGDH takes control of cell fate [PDF]
Cell Research, 2023 Linchong Sun, Ping Gao
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PHGDH Defines a Metabolic Subtype in Lung Adenocarcinomas with Poor Prognosis [PDF]
Cell Reports, 2017 Molecular signatures are emerging determinants of choice of therapy for lung adenocarcinomas. An evolving therapeutic approach includes targeting metabolic dependencies in cancers.
Boxi Zhang +7 more
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MAPK13 phosphorylates PHGDH and promotes its degradation via chaperone-mediated autophagy during liver injury [PDF]
Cell DiscoveryDrug-induced liver injury (DILI) is the leading cause of acute liver failure and poses a significant clinical challenge in both diagnosis and treatment.
Ru Xing +6 more
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Insights from Natural Product PHGDH Inhibitor Studies
Journal of Cellular Signaling, 2022 Zhaodan Wang, Xueqin Chen, Qingxiang Sun
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