Results 21 to 30 of about 8,721 (232)

Increased PHGDH expression promotes aberrant melanin accumulation

BMC Cancer, 2019
Background Copy number gain of the D-3-phosphoglycerate dehydrogenase (PHGDH) gene, which encodes the first enzyme in serine biosynthesis, is found in some human cancers including a subset of melanomas.
Katherine Mattaini, Mark R. Sullivan, Allison N. Lau, Brian P. Fiske, Matthew G. Vander Heiden   +4 more
openalex   +4 more sources

Phosphoglycerate dehydrogenase stabilizes protein kinase C delta type mRNA to promote hepatocellular carcinoma progression. [PDF]

Signal Transduct Target Ther
Metabolic reprogramming not only reshapes cellular bioenergetics but also profoundly influences RNA metabolism through metabolite signaling and the RNA-binding activities of metabolic enzymes.
Cheng B, Peng P, Chen S, Liu R, Li X, Wang K, Ma J, Wang K, Tang N, Huang A.   +9 more
europepmc   +2 more sources

Identification of a novel PHGDH covalent inhibitor by chemical proteomics and phenotypic profiling

Acta Pharmaceutica Sinica B, 2022
The first rate-limiting enzyme of the serine synthesis pathway (SSP), phosphoglycerate dehydrogenase (PHGDH), is hyperactive in multiple tumors, which leads to the activation of SSP and promotes tumorigenesis. However, only a few inhibitors of PHGDH have
Chen Chen, Tianyu Zhu, Xiaoqin Liu, Dongrong Zhu, Yi Zhang, Sifang Wu, Chao Han, Hao Zhang, Jianguang Luo, Lingyi Kong   +9 more
doaj   +1 more source

Phosphoglycerate dehydrogenase positively regulates the proliferation of chicken muscle cells

Poultry Science, 2022
: Phosphoglycerate dehydrogenase (PHGDH) is the rate-limiting enzyme in the serine synthesis pathway. However, the regulatory role of PHGDH in muscle development is unclear.
Han Wang, Moran Hu, Zhaoxue Ding, Xiaolong Zhou, Songbai Yang, Zhonghao Shen, Feifei Yan, Ayong Zhao   +7 more
doaj   +1 more source

Nuclear PHGDH regulates macrophage polarization through transcriptional repression of <i>GLUD1</i> and <i>GLS2</i> in breast cancer. [PDF]

Cancer Biol Med
Objective: Tumor-associated macrophages (TAMs) exhibit heterogeneous properties including anti-tumorigenic and pro-tumorigenic phenotypes. The rate-limiting enzyme in de novo serine biosynthesis, 3-phosphoglycerate dehydrogenase (PHGDH), has a well ...
Wang P, Du X, Han Z, Zhong J, Yuan J, Jiang L, Han B, Fu W, Li H, Hu H, Na Z.   +10 more
europepmc   +2 more sources

Low glucose metabolite 3-phosphoglycerate switches PHGDH from serine synthesis to p53 activation to control cell fate

Cell Research, 2023
Glycolytic intermediary metabolites such as fructose-1,6-bisphosphate can serve as signals, controlling metabolic states beyond energy metabolism. However, whether glycolytic metabolites also play a role in controlling cell fate remains unexplored. Here,
Yu-Qing Wu, Chensong Zhang, Jinye Xiong, Dong-Qi Cai, Chen-Zhe Wang, Yu Wang, Yan-Hui Liu, Yu Wang, Yiming Li, Jian Wu, Jianfeng Wu, Bin Lan, Xuefeng Wang, Siwei Chen, Xianglei Cao, Xiaoyan Wei, Hui-Hui Hu, Huiling Guo, Yaxin Yu, Abdul Ghafoor, Changchuan Xie, Yaying Wu, Zheni Xu, Cixiong Zhang, Mingxia Zhu, Xi Huang, Xiufeng Sun, Shuyong Lin, Hai-long Piao, Jianyin Zhou, Sheng-Cai Lin   +30 more
semanticscholar   +1 more source

PHGDH promotes esophageal squamous cell carcinoma progression via Wnt/β-catenin pathway.

Cellular Signalling, 2023
Xiaoxuan Duan, Yihuan Chen, Kai Zhang, Wei Chen, Jun Zhao, Xiaoshu Dai, Wenbo Cao, Z. Dong, Saijun Mo, Jing Lu   +9 more
semanticscholar   +2 more sources

Molecular glue triggers degradation of PHGDH by enhancing the interaction between DDB1 and PHGDH

Acta Pharmaceutica Sinica B
Cancer stem cells (CSCs) play a pivotal role in tumor initiation, proliferation, metastasis, drug resistance, and recurrence. Consequently, targeting CSCs has emerged as a promising avenue for cancer therapy.
Ziqi Huang, Kun Zhang, Yurui Jiang, Mengmeng Wang, Mei Li, Yuda Guo, Ruolin Gao, Ning Li, Chenyang Wang, Jia Chen, Jiefu Wang, Ning Liu, Xiang Liu, Shuangwei Liu, Mingming Wei, Cheng Yang, Guang Yang   +16 more
semanticscholar   +3 more sources

ZEB1 Transcriptionally Activates PHGDH to Facilitate Carcinogenesis and Progression of HCC

Cellular and Molecular Gastroenterology and Hepatology, 2023
Background & Aims: Phosphoglycerate dehydrogenase (PHGDH), the rate-limiting enzyme of the de novo serine synthesis pathway (SSP), has been implicated in the carcinogenesis and metastasis of hepatocellular carcinoma (HCC) because of its excessive ...
Huihui Wang, Furong Lin, Zhenzhen Xu, Shengnan Yu, Guannan Li, Sha Liao, Wentao Zhao, Fengqiong Zhang, Jinyan Wang, Shijie Wang, Ouyang Cong, Cixiong Zhang, Hailong Xia, Yufei Wu, Bin Jiang, Qinxi Li   +15 more
semanticscholar   +3 more sources

PHGDH activation fuels glioblastoma progression and radioresistance via serine synthesis pathway. [PDF]

J Exp Clin Cancer Res
Background Glioma stem-like cells (GSCs) are key drivers of treatment resistance and recurrence in glioblastoma (GBM). Phosphoglycerate dehydrogenase (PHGDH), a crucial enzyme in the de novo serine synthesis pathway (SSP), is implicated in tumorigenesis ...
Liu X, Liu B, Wang J, Liu H, Wu J, Qi Y, Liu Y, Zhu H, Li C, Yang L, Song J, Yao G, Tian W, Zhao K, Han L, Shu K, Zhang S, Man J, You C, Huang H, Li R.   +20 more
europepmc   +2 more sources