Results 41 to 50 of about 4,025 (191)

[Acanthamoeba keratitis treated with propamidine and polyhexamethyl biguanide (PHMB)].

Revista medica de Chile, 2002
The diagnosis of acanthamoeba keratitis has increased since 1985 due to the massive use of contact lenses and a better knowledge of the disease by ophthalmologists. The use of biassociated therapy has resulted in a better prognosis and lower complication rate.To report patients with acanthamoeba keratitis treated with the association of propamidine ...
Rodrigo, Donoso, Juan José, Mura, Mauricio, López   +2 more
openaire   +4 more sources

Further Characterization of Dopamine Release by Permeabilized PC 12 Cells [PDF]

, 1987
Rat pheochromocytoma cells (PC 12) permeabilized with staphylococcal α-toxin release [3H]dopamine after addition of micromolar Ca2+. This does not require additional Mg2+-ATP (in contrast to bovine adrenal medullary chromaffin cells).
Ahnert-Hilger G., Bader M. F., Bader M. F., Baker P. F., Bhakdi S., Bhakdi S., Brooks J. C., Dunn L. A., Ekerdt R., Flodgaard H., Gratzl M., Gudrun Ahnert-Hilger, Lowry O. H., Manfred Gratzl, Rubin R. P., Sillen L. G., Simon W., Wadstrom T., Wilson S. P.   +18 more
core   +1 more source

The Orphan Drug for Acanthamoeba Keratitis (ODAK) Trial: PHMB 0.08% (Polihexanide) and Placebo versus PHMB 0.02% and Propamidine 0.1.

Ophthalmology, 2023
To compare topical PHMB (polihexanide) 0.02% (0.2 mg/ml)+ propamidine 0.1% (1 mg/ml) with PHMB 0.08% (0.8 mg/ml)+ placebo (PHMB 0.08%) for Acanthamoeba keratitis (AK) treatment.Prospective, randomized, double-masked, active-controlled, multicenter phase 3 study (ClinicalTrials.gov identifier, NCT03274895).One hundred thirty-five patients treated at 6 ...
Dart, John K.G., Papa, Vincenzo, Rama, Paolo, Knutsson, Karl Anders, Ahmad, Saj, Hau, Scott, Sanchez, Sara, Franch, Antonella, Birattari, Federica, Leon, Pia, Fasolo, Adriano, Kominek, Ewa Mrukwa, Jadczyk-Sorek, Katarzyna, Carley, Fiona, Hossain, Parwez, Minassian, Darwin C.   +15 more
openaire   +4 more sources

Cytochrome P450 monooxygenase of Acanthamoeba castellanii participates in resistance to polyhexamethylene biguanide treatment

Parasite, 2021
Acanthamoeba spp. are free-living parasites that can cause severe infections such as granulomatous amoebic encephalitis (GAE) and amoebic keratitis (AK). Polyhexamethylene biguanide (PHMB) is a topical application for AK treatment.
Huang Jian-Ming, Ko Pin-Ju, Huang Chao-Li, Wen Po-Wei, Chen Chun-Hsien, Shih Min-Hsiu, Lin Wei-Chen, Huang Fu-Chin   +7 more
doaj   +1 more source

Testing of a dual-mode microwave care regimen for hydrogel lenses [PDF]

, 2004
Purpose. To test the design of a patient care regimen for soft lenses that aims to provide the highest standards of disinfecting through use of domestic microwave cookers, while also providing storage equipment and solution that enable patients to follow
Crabbe, A, Thompson, P
core   +1 more source

Bactericidal and Anti-biofilm Effects of Polyhexamethylene Biguanide in Models of Intracellular and Biofilm of Staphylococcus aureus Isolated from Bovine Mastitis

Frontiers in Microbiology, 2017
Staphylococcus aureus infection is a common cause of mastitis, reducing milk yield, affecting animal welfare and causing huge economic losses within the dairy industry. In addition to the problem of acquired drug resistance, bacterial invasion into udder
Nor F. Kamaruzzaman, Stacy Q. Y. Chong, Kamina M. Edmondson-Brown, Winnie Ntow-Boahene, Marjorie Bardiau, Liam Good   +5 more
doaj   +1 more source

New poly(ester urea) derived from L-leucine: Electrospun scaffolds loaded with antibacterial drugs and enzymes [PDF]

, 2015
Electrospun scaffolds from an amino acid containing poly(ester urea) (PEU) were developed as promising materials in the biomedical field and specifically in tissue engineering applications. The selected poly(ester urea) was obtained with a high yield and
Díaz Andrade, Angélica María, Katsarava, Ramaz, Puiggalí Bellalta, Jordi, Tugushi, David, Valle Mendoza, Luis Javier del   +4 more
core   +2 more sources

Antiseptic Chitosan-Poly(hexamethylene) Biguanide Hydrogel for the Treatment of Infectious Wounds

Journal of Functional Biomaterials, 2023
Topical wound infections create the ideal conditions for microbial colonization and growth in terms of moisture, temperature, and nutrients. When they are not protected, numerous types of bacteria from the internal microbiota and the external environment
Irine Rose Antony, Aathira Pradeep, Anoop Vasudevan Pillai, Riju Ramachandran Menon, Vasudevan Anil Kumar, Rangasamy Jayakumar   +5 more
doaj   +1 more source

A Prospective Randomised Clinical Study Comparing Polygalacturonic and Caprylic Acid Ointment to Medical-Grade Honey in the Management of Chronic Wounds. [PDF]

Int Wound J
ABSTRACT The aim in this human trial is to compare the efficacy and safety of polygalacturonic–caprylic acid (PG–CAP) ointment to MediHoney in chronic wounds at three international medical centres. In this prospective open‐label study, patients with chronic full‐thickness wounds were randomised to daily treatment with PG–CAP ointment or MediHoney ...
Dagher H, Hachem RY, Hakim C, Husni R, Hammoudeh DS, Karroum MB, Hamerschlak N, Assir FF, Nasr J, Rosenblatt J, Jiang Y, Wehbe S, Zeenny RM, Truong YL, Chaftari AM, Ghanem O, Ibrahim A, Bizri AR, Raad II.   +18 more
europepmc   +2 more sources

Effect of poly-hexamethylene biguanide hydrochloride (PHMB) treated non-sterile medical gloves upon the transmission of Streptococcus pyogenes, carbapenem-resistant E. coli, MRSA and Klebsiella pneumoniae from contact surfaces [PDF]

, 2017
BACKGROUND: Reduction of accidental contamination of the near-patient environment has potential to reduce acquisition of healthcare-associated infection(s).
Ali, S, Wilson, APR
core   +1 more source