Results 91 to 100 of about 2,579,257 (273)

Ubiquitin COOH-terminal hydrolase L1 deletion is associated with urinary α-klotho deficiency and perturbed phosphate homeostasis

, 2018
Loss of ubiquitin COOH-terminal hydrolase L1 (UCHL1), a deubiquitinating enzyme required for neuronal function, led to hyperphosphatemia accompanied by phosphaturia in mice, while calcium homeostasis remained intact.
Wanling Pan, Naomi C. Boisvert, Chet E. Holterman, Alexey Gutsol, R. Todd Alexander, Josée Coulombe, Douglas A. Gray, Chris R. Kennedy   +7 more
core   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Genetic suppressor screen identifies Tgp1 (glycerophosphocholine transporter), Kcs1 (IP6 kinase), and Plc1 (phospholipase C) as determinants of inositol pyrophosphate toxicosis in fission yeast

mBio
The inositol pyrophosphate signaling molecule 1,5-IP8 is an agonist of RNA 3'-processing and transcription termination in fission yeast that regulates the expression of phosphate acquisition genes pho1, pho84, and tgp1.
Lauren Bednor, Ana M. Sanchez, Angad Garg, Stewart Shuman, Beate Schwer   +4 more
doaj   +1 more source

Phosphate in Virulence of Candida albicans and Candida glabrata

Journal of Fungi, 2020
Candida species are the most commonly isolated invasive human fungal pathogens. A role for phosphate acquisition in their growth, resistance against host immune cells, and tolerance of important antifungal medications is becoming apparent.
Julia R. Köhler, Maikel Acosta-Zaldívar, Wanjun Qi   +2 more
doaj   +1 more source

GmPHR25, a GmPHR member up-regulated by phosphate starvation, controls phosphate homeostasis in soybean

Journal of Experimental Botany, 2017
GmPHR25, which is up-regulated by phosphate starvation, is a vital regulator in the phosphorus signaling network, and controls phosphate homeostasis in soybean.
Ying-bin Xue, Bi-Xian Xiao, Shengnan Zhu, X. Mo, Cui-Yue Liang, Jiang Tian, H. Liao, Gifford Miriam   +7 more
semanticscholar   +1 more source

The osteocyte--a novel endocrine regulator of body phosphate homeostasis.

, 2010
Although osteocytes are the most abundant cell type in bone, much of their biology remains enigmatic. They are known to transduce mechanical stress into signals that initiate local bone remodeling, and are targets for systemic and local endocrine signals
Fan Cheng, Philippa Hulley
core   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Endocrine Phosphate Resistance

, 2016
Calcium and phosphate homeostasis in healthy individuals and in Teutschlaender's disease caused by endocrine phosphate resistance.
Johannes Wolfgang Christian Dietrich (3192570)
core   +1 more source

Investigating the role of phosphate homeostasis in Staphylococcus aureus virulence [PDF]

, 2021
Due to its use in DNA, energy storage, intracellular signaling, and other important biological processes, phosphate is an essential nutrient for all organisms. Bacteria possess a variety of complex phosphate sensing and uptake systems to ensure that they
Joya Sandoval, Eliot Scottie
core  

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source