Results 101 to 110 of about 2,579,257 (273)

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Characterization of the rice NLA family reveals a key role for OsNLA1 in phosphate homeostasis

Rice, 2017
Background Phosphate (Pi), an essential mineral nutrient for plant development and reproduction, is one of the main components of fertilizers in modern agriculture.
Jian Yang, Lan Wang, Chuanzao Mao, Honghui Lin   +3 more
doaj   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

Intracellular phosphate homeostasis - A short way from metabolism to signaling.

Plant Science, 2019
Phosphorus in plant cells occurs in inorganic form as both ortho- and pyrophosphate or bound to organic compounds, like e.g., nucleotides, phosphorylated metabolites, phospholipids, phosphorylated proteins, or phytate as P storage in the vacuoles of ...
Izabela Fabiańska, M. Bucher, R. Häusler   +2 more
semanticscholar   +1 more source

Polyphosphate synthesis is essential for phosphate and ATP homeostasis during nutrient upshift [PDF]

Inorganic polyphosphate (polyP) is a ubiquitous molecule found across all domains of life. Although implicated in diverse cellular processes, including phosphate storage, stress responses and pathogenicity, loss of polyP synthesis typically causes only ...
Chien, Peter, Mortier, Julien, Granqvist, Lova, Aldikacti, Berent, Jonas, Kristina, Louski, Max, Crang, Nick, White, Maria L.,, Mortier, Julien,, Louski, Max,, Chien, Peter,, Hennequart, Marc,, Migeot, Valérie,, Hallez, Régis, Crang, Nick,, Jonas, Kristina,, Hallez, Régis,, Aldikacti, Berent,, White, Maria L., Migeot, Valérie, Omnus, Deike Johanne,, Omnus, Deike J., White, Maria Louise,, Granqvist, Lova,, Omnus, Deike J.,, Hennequart, Marc   +25 more
core   +1 more source

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

Phosphate transport across biomembranes and cytosolic phosphate homeostasis in barley leaves

, 1990
Mimura T, Dietz K-J, Kaiser W, Schramm MJ, Kaiser G, Heber U. Phosphate transport across biomembranes and cytosolic phosphate homeostasis in barley leaves. Planta.
Dietz, Karl-Josef, Heber, U., Mimura, T., Schramm, M. J., Kaiser, W., Kaiser, G.   +5 more
core  

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source

Phosphate in Physiological and Pathological Mineralization: Important yet Often Unheeded

MedComm
Phosphate is an important element in biological processes, particularly in the formation and metabolism of mineralized tissues such as bones and teeth. The imbalance of phosphate is also closely related with pathological mineralization.
Wen Qin, San‐yang Yu, Jia‐lu Gao, Jian‐fei Yan, Qian‐qian Wan, Shuai‐lin Jia, Franklin Tay, Kai Jiao, Lina Niu   +8 more
doaj   +1 more source

Genome Wide Transcriptome Analysis Reveals Complex Regulatory Mechanisms Underlying Phosphate Homeostasis in Soybean Nodules

International Journal of Molecular Sciences, 2018
Phosphorus (P) deficiency is a major limitation for legume crop production. Although overall adaptations of plant roots to P deficiency have been extensively studied, only fragmentary information is available in regard to root nodule responses to P ...
Ying-bin Xue, Qingli Zhuang, Shengnan Zhu, Bi-Xian Xiao, Cui-Yue Liang, H. Liao, Jiang Tian   +6 more
semanticscholar   +1 more source