Results 111 to 120 of about 832,790 (296)

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Roles of Pho regulon in bacterial pathogenicity

Virulence
Bacterial infections are a leading cause of global health loss. The prerequisites for bacteria to colonize and establish systemic infection in the host are environmental adaptability and the expression of virulence factors.
Jing Yang, Min Wang, Yi Wang, Rui Qiang, Qiyuan Jin, Chenhao Zhao, Qi Chen, Mingxiao Han, Xin Ma, Haifang Zhang   +9 more
doaj   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Acidocalcisome-like vacuoles constitute a feedback-controlled phosphate buffering system for the cytosol

eLife
Cells experience strong variations in the consumption and availability of inorganic phosphate (Pi). Since Pi is an essential macronutrient but excess Pi has negative impacts on nucleotide hydrolysis and metabolism, its concentration must be maintained in
Samuel Bru, Lydie Michaillat Mayer, Geun-Don Kim, Danye Qiu, Henning J Jessen, Andreas Mayer   +5 more
doaj   +1 more source

The transcription factor PHR1 plays a key role in the regulation of sulfate shoot-to-root flux upon phosphate starvation in Arabidopsis

BMC Plant Biology, 2011
Background Sulfate and phosphate are both vital macronutrients required for plant growth and development. Despite evidence for interaction between sulfate and phosphate homeostasis, no transcriptional factor has yet been identified in higher plants that ...
Arpat Bulak, Secco David, Rouached Hatem, Poirier Yves   +3 more
doaj   +1 more source

Glucose-6-phosphate-dehydrogenase deficiency as a risk factor in proliferative disorder development [PDF]

, 2009
Glucose-6-phosphate dehydrogenase (G6PD) is an important site of metabolic control in the pentose phosphate pathway (PPP) which provides reducing power (NADPH) and pentose phosphates.
Alessandra Pani, Antonella Mandas, Claudia Abete, Claudia Norfo, Enrico Peiretti, Fabrizio Angius, Giacomo Diaz, Maurizio Fossarello, Pierluigi Cocco, Sandra Dessì   +9 more
core   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Bone-kidney-endocrine axis in nephrolithiasis and crystalluria

Mìžnarodnij Endokrinologìčnij Žurnal
Background. Nephrolithiasis (NL) is a common polyetiological urological disease with multifactorial pathogenesis. In recent years, increasing attention has been paid to the association between NL and alterations in bone mineral density (BMD ...
O.D. Nikitin, I.A. Kordubailo, O.I. Nishkumay, H.D. Reznikov, Mike K.S. Chan   +4 more
doaj   +1 more source

Integration of P, S, Fe and Zn nutrition signals in Arabidopsis thaliana : potential involvement of PHOSPHATE STARVATION RESPONSE 1 (PHR1).

Frontiers in Plant Science, 2015
Phosphate and sulfate are essential macro-elements for plant growth and development, and deficiencies in these mineral elements alter many metabolic functions. Nutritional constraints are not restricted to macro-elements.
Jean-Francois eBRIAT, Hatem eROUACHED, Nicolas eTISSOT, Frederic eGAYMARD, Christian eDUBOS   +4 more
doaj   +1 more source