Results 111 to 120 of about 463,152 (355)

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Phosphorus and Fluorine - The Union for Bioregulators [PDF]

Kemija u Industriji, 2007
The review demonstrates the very high efficiency and usefulness of the fluorine-phosphorus combination in order to synthesize organic molecules for purposes of modern life science.
Romanenko, V., Kukhar, V.
doaj  

Phosphate level predicts mortality in acute kidney injury patients undergoing continuous kidney replacement therapy and has a U-shaped association with mortality in patients with high disease severity: a multicenter retrospective study [PDF]

Kidney Research and Clinical Practice
Background This study investigated the association between serum phosphate level and mortality in acute kidney injury (AKI) patients undergoing continuous kidney replacement therapy (CKRT) and evaluated whether this association differed according to ...
Young Hwan Lee, Soyoung Lee, Yu Jin Seo, Jiyun Jung, Jangwook Lee, Jae Yoon Park, Tae Hyun Ban, Woo Yeong Park, Sung Woo Lee, Kipyo Kim, Kyeong Min Kim, Hyosang Kim, Ji-Young Choi, Jang-Hee Cho, Yong Chul Kim, Jeong-Hoon Lim   +15 more
doaj   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Comprehensive effect of Al2O3 content and binary basicity on the enrichment mechanism of phosphates in quenched steelmaking slags

工程科学学报, 2016
A comprehensive effect of Al2O3 content and binary basicity B on the enrichment behavior of phosphates in rapidly quenched CaO-SiO2-FeO-P2O5-Fe2O3-Al2O3 steelmaking slags was investigated through thermodynamic calculations and experimental determination.
LI Jin-yan, ZHANG Mei, GUO Min, YANG Xue-min   +3 more
doaj   +1 more source

The Initial and Residual Value of Phosphorus from Apatite Rock Phosphates and Superphosphates as Measured by 32p Dilution Technique [PDF]

, 1990
A pot trial using maize (Zea mays, L.) grown on an Ultisollabelled with 32p was carried out to evaluate the agronomic value of nine types of apatite rock phosphates and triple superphosphate.
Abdul Hamid, Sharifuddin, Abdul Rahman, Zaharah   +1 more
core  

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Agronomic effectiveness of rock phosphates for corrective fertilization of an Oxisol from brazilian savanna cultivated with maize and common beans. [PDF]

, 2015
Due to the inherently low content and high degree of phosphorus fixation in the most part of Brazilian Savanna soils, Phosphorus fertilization is essential to attend crop demands. The fully acidulated phosphates are the main sources of Phosphorus used in
CARVALHO, M. da C. S., FAGERIA, N. K., NASCENTE, A. S. S., OLIVEIRA JÚNIOR, A. de   +3 more
core  

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source