Results 1 to 10 of about 5,041,800 (310)
Optical Control of Phosphatidic Acid Signaling [PDF]
Phosphatidic acids (PAs) are glycerophospholipids that regulate key cell signaling pathways governing cell growth and proliferation, including the mTOR and Hippo pathways.
Reika Tei+4 more
doaj +5 more sources
Phosphatidic acid is an endogenous negative regulator of PIEZO2 channels and mechanical sensitivity [PDF]
Mechanosensitive PIEZO2 ion channels play roles in touch, proprioception, and inflammatory pain. Currently, there are no small molecule inhibitors that selectively inhibit PIEZO2 over PIEZO1. The TMEM120A protein was shown to inhibit PIEZO2 while leaving
Matthew Gabrielle+4 more
doaj +2 more sources
Regulation of Signaling and Metabolism by Lipin-mediated Phosphatidic Acid Phosphohydrolase Activity
Phosphatidic acid (PA) is a glycerophospholipid intermediate in the triglyceride synthesis pathway that has incredibly important structural functions as a component of cell membranes and dynamic effects on intracellular and intercellular signaling ...
Andrew J. Lutkewitte, Brian N. Finck
doaj +2 more sources
Crystal structure of a lipin/Pah phosphatidic acid phosphatase
Lipin/Pah phosphatidic acid phosphatases generate diacylglycerol to regulate triglyceride synthesis and cellular signaling. Here authors determine structures of Tetrahymena thermophila Pah2 and identify an N-terminal amphipathic helix essential for ...
Valerie I. Khayyo+6 more
doaj +2 more sources
Phosphatidic Acid: From Pleiotropic Functions to Neuronal Pathology
Among the cellular lipids, phosphatidic acid (PA) is a peculiar one as it is at the same time a key building block of phospholipid synthesis and a major lipid second messenger conveying signaling information.
Emeline Tanguy+3 more
doaj +2 more sources
Phosphatidic acid inhibits SCAB1-mediated F-actin bundling in Arabidopsis [PDF]
Stomatal closure-associated actin-binding protein 1 (SCAB1) regulates stomatal closure by mediating actin filament reorganization in Arabidopsis thaliana.
Haiqi Fu+6 more
doaj +2 more sources
Phosphatidic Acid Accumulates at Areas of Curvature in Tubulated Lipid Bilayers and Liposomes [PDF]
Phosphatidic acid (PA) is a signaling lipid that is produced enzymatically from phosphatidylcholine (PC), lysophosphatidic acid, or diacylglycerol. Compared to PC, PA lacks a choline moiety on the headgroup, making the headgroup smaller than that of PC ...
Broderick L. Bills, Michelle K. Knowles
doaj +2 more sources
Phosphatidic acid: from biophysical properties to diverse functions
Phosphatidic acid (PA), the simplest phospholipid, acts as a key metabolic intermediate and second messenger that impacts diverse cellular and physiological processes across species ranging from microbes to plants and mammals.
Hejiang Zhou, Yanwu Huo, Na Yang, T. Wei
semanticscholar +1 more source
Thaller et al. demonstrate that direct binding between phosphatidic acid (PA) and the ESCRT Chm7 is required for nuclear envelope surveillance; PA also accumulates at nuclear envelope herniations.
David J. Thaller+8 more
semanticscholar +1 more source
DDHD1 and DDHD2 are both intracellular phospholipases A1 and hydrolyze phosphatidic acid in vitro. Given that phosphatidic acid participates in neurite outgrowth, we examined whether DDHD1 and DDHD2 regulate neurite outgrowth.
Yuki Maemoto+8 more
doaj +1 more source