Results 1 to 10 of about 47,232 (289)

Phosphatidic acid is an endogenous negative regulator of PIEZO2 channels and mechanical sensitivity [PDF]

Nature Communications
Mechanosensitive PIEZO2 ion channels play roles in touch, proprioception, and inflammatory pain. Currently, there are no small molecule inhibitors that selectively inhibit PIEZO2 over PIEZO1. The TMEM120A protein was shown to inhibit PIEZO2 while leaving
Matthew Gabrielle, Yevgen Yudin, Yujue Wang, Xiaoyang Su, Tibor Rohacs   +4 more
doaj   +4 more sources

Fine-tuning phosphatidic acid production for optimal plant stress responses. [PDF]

Trends Biochem Sci
Gong Q, Yao S, Wang X, Li G.
europepmc   +3 more sources

GDE7 produces cyclic phosphatidic acid in the ER lumen functioning as a lysophospholipid mediator. [PDF]

Commun Biol, 2023
Kitakaze K, Ali H, Kimoto R, Takenouchi Y, Ishimaru H, Yamashita A, Ueda N, Tanaka T, Okamoto Y, Tsuboi K.   +9 more
europepmc   +3 more sources

DDHD1, but Not DDHD2, Suppresses Neurite Outgrowth in SH-SY5Y and PC12 Cells by Regulating Protein Transport From Recycling Endosomes

Frontiers in Cell and Developmental Biology, 2020
DDHD1 and DDHD2 are both intracellular phospholipases A1 and hydrolyze phosphatidic acid in vitro. Given that phosphatidic acid participates in neurite outgrowth, we examined whether DDHD1 and DDHD2 regulate neurite outgrowth.
Yuki Maemoto, Tomohiro Maruyama, Kazuaki Nemoto, Takashi Baba, Takashi Baba, Manae Motohashi, Akihiro Ito, Mitsuo Tagaya, Katsuko Tani   +8 more
doaj   +1 more source

The PDZ domain of the guanine nucleotide exchange factor PDZGEF directs binding to phosphatidic acid during brush border formation. [PDF]

PLoS ONE, 2014
PDZGEF is a guanine nucleotide exchange factor for the small G protein Rap. It was recently found that PDZGEF contributes to establishment of intestinal epithelial polarity downstream of the kinase Lkb1.
Sarah V Consonni, Patricia M Brouwer, Eleonora S van Slobbe, Johannes L Bos   +3 more
doaj   +1 more source

Phosphatidic acid-dependent recruitment of microtubule motors to spherical supported lipid bilayers for in vitro motility assays. [PDF]

Cell Rep
Kumar P, Chaudhury D, Sanghavi P, Meghna A, Mallik R.   +4 more
europepmc   +2 more sources

Effects of ionization and counterion binding on the surface areas of phosphatidic acids in monolayers.

Journal of Lipid Research, 1979
At 24-26 degrees C, force-area isotherms show that unionized dipalmitoyl phosphatidic acid forms a solid-condensed film while unionized egg and dioleoyl phosphatidic acids form liquid-expanded films. Surface area is a characteristic feature of a specific
G S Patil, N J Dorman, D G Cornwell
doaj   +1 more source

Insulin Action on Polyunsaturated Phosphatidic Acid Formation in Rat Brain: An “In Vitro” Model with Synaptic Endings from Cerebral Cortex and Hippocampus [PDF]

, 2009
The highly efficient formation of phosphatidic acid from exogenous 1-stearoyl-2-arachidonoyl-sn-glycerol (SAG) in rat brain synaptic nerve endings (synaptosomes) from cerebral cortex and hippocampus is reported.
Giusto, Norma Maria, Ilincheta, Monica Graciela, Zulian, Sandra Edith   +2 more
core   +1 more source

Characterization of key triacylglycerol biosynthesis processes in rhodococci. [PDF]

, 2016
Oleaginous microorganisms have considerable potential for biofuel and commodity chemical production. Under nitrogen-limitation, Rhodococcus jostii RHA1 grown on benzoate, an analog of lignin depolymerization products, accumulated triacylglycerols (TAGs ...
Amara, Sawsan, Diaz-Salazar, Carlos, Eltis, Lindsay D, Liu, Jie, Otani, Hiroshi, Seghezzi, Nicolas   +5 more
core   +2 more sources

A Sec14 domain protein is required for photoautotrophic growth and chloroplast vesicle formation in Arabidopsis thaliana. [PDF]

, 2020
In eukaryotic photosynthetic organisms, the conversion of solar into chemical energy occurs in thylakoid membranes in the chloroplast. How thylakoid membranes are formed and maintained is poorly understood.
Armbruster, Ute, García-Cerdán, José G, Hertle, Alexander P, Lee, Jimmy J, Niyogi, Krishna K, Shih, Robert, Wong, Winnie   +6 more
core   +2 more sources