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Optical Control of Phosphatidic Acid Signaling [PDF]
ACS Central Science, 2021 Phosphatidic acids (PAs) are glycerophospholipids that regulate key cell signaling pathways governing cell growth and proliferation, including the mTOR and Hippo pathways.
Reika Tei +4 more
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Phosphatidic acid is an endogenous negative regulator of PIEZO2 channels and mechanical sensitivity [PDF]
Nature CommunicationsMechanosensitive PIEZO2 ion channels play roles in touch, proprioception, and inflammatory pain. Currently, there are no small molecule inhibitors that selectively inhibit PIEZO2 over PIEZO1. The TMEM120A protein was shown to inhibit PIEZO2 while leaving
Matthew Gabrielle +4 more
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Regulation of Signaling and Metabolism by Lipin-mediated Phosphatidic Acid Phosphohydrolase Activity
Biomolecules, 2020 Phosphatidic acid (PA) is a glycerophospholipid intermediate in the triglyceride synthesis pathway that has incredibly important structural functions as a component of cell membranes and dynamic effects on intracellular and intercellular signaling ...
Andrew J. Lutkewitte, Brian N. Finck
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Crystal structure of a lipin/Pah phosphatidic acid phosphatase
Nature Communications, 2020 Lipin/Pah phosphatidic acid phosphatases generate diacylglycerol to regulate triglyceride synthesis and cellular signaling. Here authors determine structures of Tetrahymena thermophila Pah2 and identify an N-terminal amphipathic helix essential for ...
Valerie I. Khayyo +6 more
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Phosphatidic Acid: From Pleiotropic Functions to Neuronal Pathology
Frontiers in Cellular Neuroscience, 2019 Among the cellular lipids, phosphatidic acid (PA) is a peculiar one as it is at the same time a key building block of phospholipid synthesis and a major lipid second messenger conveying signaling information.
Emeline Tanguy +3 more
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Phosphatidic acid inhibits SCAB1-mediated F-actin bundling in Arabidopsis [PDF]
Plant Signaling & Behavior, 2023 Stomatal closure-associated actin-binding protein 1 (SCAB1) regulates stomatal closure by mediating actin filament reorganization in Arabidopsis thaliana.
Haiqi Fu +6 more
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Phosphatidic Acid Accumulates at Areas of Curvature in Tubulated Lipid Bilayers and Liposomes [PDF]
Biomolecules, 2022 Phosphatidic acid (PA) is a signaling lipid that is produced enzymatically from phosphatidylcholine (PC), lysophosphatidic acid, or diacylglycerol. Compared to PC, PA lacks a choline moiety on the headgroup, making the headgroup smaller than that of PC ...
Broderick L. Bills, Michelle K. Knowles
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Phosphatidic acid: from biophysical properties to diverse functions
The FEBS Journal, 2023 Phosphatidic acid (PA), the simplest phospholipid, acts as a key metabolic intermediate and second messenger that impacts diverse cellular and physiological processes across species ranging from microbes to plants and mammals.
Hejiang Zhou, Yanwu Huo, Na Yang, T. Wei
semanticscholar +1 more source
Journal of Cell Biology, 2021 Thaller et al. demonstrate that direct binding between phosphatidic acid (PA) and the ESCRT Chm7 is required for nuclear envelope surveillance; PA also accumulates at nuclear envelope herniations.
David J. Thaller +8 more
semanticscholar +1 more source
Frontiers in Cell and Developmental Biology, 2020 DDHD1 and DDHD2 are both intracellular phospholipases A1 and hydrolyze phosphatidic acid in vitro. Given that phosphatidic acid participates in neurite outgrowth, we examined whether DDHD1 and DDHD2 regulate neurite outgrowth.
Yuki Maemoto +8 more
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