Results 61 to 70 of about 3,207 (207)
Nature Communications, 2021 Apicomplexa generate essential lipids as combination of host fatty acids and de novo synthesized within the apicoplast. Here, the authors identify a phosphatidic acid phosphatase in Toxoplasma gondii, TgLIPIN, as central for controlled lipid synthesis ...
Sheena Dass +9 more
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Phosphatidic acid, phospholipase D and tumorigenesis
Advances in Biological Regulation, 2014 Phospholipase D (PLD) is a membrane protein with a double role: maintenance of the structural integrity of cellular or intracellular membranes and involvement in cell signaling through the product of the catalytic reaction, PA, and through protein-protein interaction with a variety of partners.
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Fatty Acids of Human Platelet Phosphatides.
Experimental Biology and Medicine, 1961 SummaryThe fatty acids of blood platelet phosphatides have ben studied by silicic acid, and gas-liquid chromatography. PEPS fractions contain primarily arachidonic, stearic and oleic acids. Lecithin-sphingomyelin eluates contain principally palmitic, stearic and oleic acids.
A J, MARCUS, H L, ULLMAN, H S, BALLARD
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Phosphatidic Acid and Cardiolipin Coordinate Mitochondrial Dynamics [PDF]
Trends in Cell Biology, 2018 Membrane organelles comprise both proteins and lipids. Remodeling of these membrane structures is controlled by interactions between specific proteins and lipids. Mitochondrial structure and function depend on regulated fusion and the division of both the outer and inner membranes.
Shoichiro, Kameoka +4 more
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British Journal of Pharmacology, EarlyView.Cannabidiol (CBD) and cannabigerol (CBG) alleviate hepatic steatosis in obese mice by shifting energy buffering towards phosphocreatine and enhancing lysosomal lipid degradation and trafficking. These effects are associated with increased creatine kinase activity and lysobisphosphatidic acid (LBPA) levels, highlighting a previously unrecognised ...
Radka Kočvarová +12 more
wiley +1 more source
Phosphatidic Acid: From Pleiotropic Functions to Neuronal Pathology
Frontiers in Cellular Neuroscience, 2019 Among the cellular lipids, phosphatidic acid (PA) is a peculiar one as it is at the same time a key building block of phospholipid synthesis and a major lipid second messenger conveying signaling information.
Emeline Tanguy +3 more
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Diabetes, Obesity and Metabolism, EarlyView.ABSTRACT Aims Cold exposure activates brown adipose tissue (BAT) and promotes thermogenic and metabolic adaptations. While BAT activation has been linked to improved cardiometabolic health, how acute cold exposure reshapes the circulating lipidome in humans remains incompletely understood.
Yu Zhang +7 more
wiley +1 more source
The FEBS Journal, EarlyView.Ferroptosis is driven by unrestricted peroxidation of polyunsaturated fatty acyl (PUFA) chains in membrane phospholipids. In triple‐negative breast cancer cells, lipid droplets (LDs) sequester dietary PUFAs, limiting their incorporation into membrane phospholipids, preventing mitochondrial damage, and reducing lipid peroxidation and ferroptosis.
Ana Kump +10 more
wiley +1 more source
Nature Communications, 2016 CtBP1-S/BARS is required for fission of endomembrane compartments including the Golgi. Here the authors show that CtBP1-S/BARS activates a trans-Golgi lysophosphatidic acid acyltransferase that catalyses the production of phosphatidic acid and is ...
Alessandro Pagliuso +13 more
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Regulation of phosphatidic acid biosynthetic enzymes in Saccharomyces cerevisiae.
Journal of Lipid Research, 1994 Phosphatidic acid is the biosynthetic precursor of all glycerolipids. To understand how phosphatidic acid biosynthesis is controlled in Saccharomyces cerevisiae, we studied the regulation of three enzyme activities involved in the synthesis of this ...
S A Minskoff +5 more
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