Effect of oral administration of soy-derived phosphatidic acid on concentrations of phosphatidic acid and lyso-phosphatidic acid molecular species in human plasma [PDF]
Background The glycerophospholipid Phosphatidic acid (PA) has been identified as a potential nutritional treatment for gastrointestinal disorders. Dietary food sources rich in PA include cabbage and radish leaves as well as Mallotus japonicas, a Japanese edible herb historically used for the treatment of stomach ulcers.
Ryan P. Lowery+5 more
openaire +2 more sources
Sarcopenia from mechanism to diagnosis and treatment in liver disease [PDF]
Sarcopenia or loss of skeletal muscle mass is the major component of malnutrition and is a frequent complication in cirrhosis that adversely affects clinical outcomes.
Dasarathy, Srinivasan, MERLI, Manuela
core +1 more source
Modulation of 1,25-dihydroxyvitamin D3 receptor by phospholipids and fatty acids.
The structural relationship between several lipids and their respective capacities to inhibit the specific binding of [3H]-1,25 (OH)2 vitamin D3 to chick intestinal cytosol preparations was investigated.
T C Chen, J P Mullen, N J Meglin
doaj +1 more source
An amphitropic cAMP-binding protein in yeast mitochondria [PDF]
: We describe the first example of a mitochondrial protein with a covalently attached phos-phatidylinositol moiety acting as a membrane anchor. The protein can be metabolically labeled with both stearic acid and inositol.
Bandlow W.+43 more
core +3 more sources
Tip60-mediated lipin 1 acetylation and ER translocation determine triacylglycerol synthesis rate
The acetyltransferase Tip60 mediates signaling pathways by acetylating non-histone proteins. Here the authors show that fatty acids induce Tip60–dependent acetylation of phosphatidic acid phosphatase lipin1 which, then, translocates to the ER and ...
Terytty Yang Li+16 more
doaj +1 more source
Acceptors of fatty acid for glyceride synthesis in guinea pig mammary gland
Glycerides are shown to be synthesized by two pathways in mammary tissue of lactating guinea pigs. One pathway involves the direct acylation of monoglycerides.
O.W. McBride, Edward D. Korn
doaj +1 more source
Recent advances in expanding the coverage of the lipidome [PDF]
The lipidome comprises a large array of molecules with diverse physicochemical properties. Lipids are structural components of cells, act as a source of energy, and function as signaling mediators.
Kamphorst, Jurre J., Tumanov, Sergey
core +1 more source
Seipin oligomers can interact directly with AGPAT2 and lipin 1, physically scaffolding critical regulators of adipogenesis [PDF]
This work was supported by a Merit Scholarship from the Islamic Development Bank (to M.M.U.T.), The Agency for Science, Technology and Research, Singapore (A*STAR) (M.F.M.S), the Medical Research Council (MRC) [NIRG GO800203 and Research Grant MR/L002620/
Edwardson, J Michael+4 more
core +2 more sources
Bioactive lipids in gintonin-enriched fraction from ginseng
Background: Ginseng is a traditional herbal medicine for human health. Ginseng contains a bioactive ligand named gintonin. The active ingredient of gintonin is lysophosphatidic acid C18:2 (LPA C18:2).
Hee-Jung Cho+7 more
doaj +1 more source
The pleiotropic transcriptional regulator NlpR contributes to the modulation of nitrogen metabolism, lipogenesis and triacylglycerol accumulation in oleaginous rhodococci [PDF]
The regulatory mechanisms involved in lipogenesis and triacylglycerol (TAG) accumulation are largely unknown in oleaginous rhodococci. In this study a regulatory protein (here called NlpR: Nitrogen lipid Regulator), which contributes to the modulation of
Alvarez, Hector Manuel+4 more
core +1 more source