Results 51 to 60 of about 20,811 (292)

Identification of atypical ether-linked glycerophospholipid species in macrophages by mass spectrometry

Journal of Lipid Research, 2010
A large scale profiling and analysis of glycerophospholipid species in macrophages has facilitated the identification of several rare and atypical glycerophospholipid species.
Pavlina T. Ivanova, Stephen B. Milne, H. Alex Brown   +2 more
doaj   +1 more source

Anti-Obesity and Gut Microbiota Regulation Effects of Phospholipids from the Eggs of Crab, Portunus Trituberculatus, in High Fat Diet-Fed Mice

Marine Drugs, 2022
There are resourceful phospholipids in the eggs of the crab, Portunus trituberculatus (Pt-PL). However, their components and bioactivities regarding obesity were unclear. Here, we investigated the composition of Pt-PL and their fatty acids. Moreover, its
Laijin Su, Hongli Zhu, Sichun Chen, Mengyu Du, Xiaofeng Wan, Yishu Liu, Shiwei Hu, Yangli Xu   +7 more
doaj   +1 more source

Targeting PLD3 Reverses the Immunosuppressive Niche by Reprogramming Tumor‐Associated Macrophages and Potentiates Antitumor Immunity

Advanced Science, EarlyView.
PLD3 activates the lysosomal‐AKT‐NF‐κB axis to drive cellular senescence in macrophages, establishing an immunosuppressive TME by limiting the infiltration of cytotoxic T, NK, and NKT cells, which confers resistance to anti‐PD‐1 therapy. Abrine inhibits PLD3 expression, restoring antitumor immunity and synergizing with anti‐PD‐1 treatment.
Xingtu Qin, Qiong Li, Xuemei Xu, Yuhan Wu, Yin Zhu, Jieqiong Wu, Yuan Fang, Qiubei Chen, Shuyang Wang, Jiang Yu, Yaping Ye, Hongli Jiao   +11 more
wiley   +1 more source

Apicoplast-Localized Lysophosphatidic Acid Precursor Assembly Is Required for Bulk Phospholipid Synthesis in Toxoplasma gondii and Relies on an Algal/Plant-Like Glycerol 3-Phosphate Acyltransferase.

PLoS Pathogens, 2016
Most apicomplexan parasites possess a non-photosynthetic plastid (the apicoplast), which harbors enzymes for a number of metabolic pathways, including a prokaryotic type II fatty acid synthesis (FASII) pathway.
Souad Amiar, James I MacRae, Damien L Callahan, David Dubois, Giel G van Dooren, Melanie J Shears, Marie-France Cesbron-Delauw, Eric Maréchal, Malcolm J McConville, Geoffrey I McFadden, Yoshiki Yamaryo-Botté, Cyrille Y Botté   +11 more
doaj   +1 more source

Chemical composition of seeds of four Bulgarian grape varieties [PDF]

Ciência e Técnica Vitivinícola, 2016
The composition of grape seeds from two white dessert (‘Bolgar’ and ‘Super ran Bolgar’) and two red wine Bulgarian varieties (‘Mavroud’ and ‘Shiroka melnishka loza’) was investigated.
Ovcharova Temenuzhka, Zlatanov M., Dimitrova R.   +2 more
doaj   +1 more source

Diacylglycerol kinases as sources of phosphatidic acid [PDF]

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2009
There are ten mammalian diacylglycerol kinases (DGKs) whose primary role is to terminate diacylglycerol (DAG) signaling. However, it is becoming increasingly apparent that DGKs also influence signaling events through their product, phosphatidic acid (PA).
Jinjin, Cai, Hanan, Abramovici, Stephen H, Gee, Matthew K, Topham   +3 more
openaire   +2 more sources

Lipid metabolism disorders contribute to hepatotoxicity of ICR mice induced by nitrosamines exposure

Environment International, 2022
Health risks caused by crucial environmental carcinogens N-nitrosamines triggered ubiquitous attention. As the liver exerted vital function through metabolic process, lipid metabolism disorders have been confirmed as potential drivers for toxicological ...
Hu Zhang, Lu Lu, Chao Zhao, Qiwei Liu, Qian Zhou, Ying Zhang, Yuepu Pu, Shizhi Wang, Ran Liu, Lihong Yin   +9 more
doaj   +1 more source

Phospholipases A1

, 2011
Research in the author's laboratory is supported in part by a Wellcome Trust Senior Research Fellowship (067441), and Wellcome Trust project grants (086658 and 093228) and a Wellcome Trust Prize Studentship (G.S.R).Phospholipase A1 (PLA1) is an enzyme ...
Smith, Terry K., Gregory S. Richmond, Terry K. Smith, Richmond, Gregory S.   +3 more
core   +1 more source

A phosphatidic acid-binding lncRNA SNHG9 facilitates LATS1 liquid–liquid phase separation to promote oncogenic YAP signaling [PDF]

, 2021
Long noncoding RNAs (lncRNAs) are emerging as a new class of important regulators of signal transduction in tissue homeostasis and cancer development. Liquid–liquid phase separation (LLPS) occurs in a wide range of biological processes, while its role in
Liu, Fang-Zhou, Li, Jun-Hong, Li, Xu, Xiong, Yan, Zhang, Zhen, Wang, Liang-Jing, Zhou, Tianhua, Li, Rui-Hua, Lin, Aifu, Yan, Qingfeng, Shao, Jian-Zhong, Tian, Tian, Ju, Huai-Qiang, Wang, Wenqi, Shi, Cheng-Yu, Ge, Qi-Wei, Liu, Ya-Zhuo, Liu, Jian, He, Xin-Yu, Sang, Ling-Jie, Yang, Zuo-Zhen   +20 more
core   +1 more source

Characterization of the total lipid and fatty acid composition of rat olfactory mucosa.

Journal of Lipid Research, 1989
Phospholipid accounted for 81% (by weight) of the total lipid of rat olfactory mucosa. Phosphatidylcholine (46% of total phospholipids) and phosphatidylethanolamine (26%) were the predominant phospholipids.
Y Russell, P Evans, G H Dodd
doaj   +1 more source