Results 71 to 80 of about 20,811 (292)

Type I IFN induces long-chain acyl-CoA synthetase 1 to generate a phosphatidic acid reservoir for lipotoxic saturated fatty acids

Journal of Lipid Research
Long-chain acyl-CoA synthetase 1 (ACSL1) catalyzes the conversion of long-chain fatty acids to acyl-CoAs. ACSL1 is required for β-oxidation in tissues that rely on fatty acids as fuel, but no consensus exists on why ACSL1 is induced by inflammatory ...
Shelley Barnhart, Masami Shimizu-Albergine, Eyal Kedar, Vishal Kothari, Baohai Shao, Melissa Krueger, Cheng-Chieh Hsu, Jingjing Tang, Jenny E. Kanter, Farah Kramer, Danijel Djukovic, Vadim Pascua, Yueh-Ming Loo, Lucrezia Colonna, Sadie J. Van den Bogaerde, Jie An, Michael Gale, Jr., Karen Reue, Edward A. Fisher, Sina A. Gharib, Keith B. Elkon, Karin E. Bornfeldt   +21 more
doaj   +1 more source

Analysis of naturally occurring mutations in the human lipodystrophy protein seipin reveals multiple potential pathogenic mechanisms [PDF]

, 2013
Peer ...
Dennis, Rowena J, O'Rahilly, Stephen, Edwardson, J Michael, Talukder, M Mesbah Uddin, Sim, M F Michelle, Rochford, Justin J   +5 more
core   +1 more source

Enviromics crosstalk between internal and external plant environments for enhanced adaptation and de novo domestication

iMeta, EarlyView.
Climate change demands accelerated plant adaptation and de novo domestication. Yet current enviromics focuses disproportionately on external environments, neglecting internal dynamics—gene expression, metabolic flux, and signal transduction—within predictive envirotyping frameworks.
Yunbi Xu, Feng Yu, Lin‐An Zhang, Xuan Dong, Kai Liu, Nicolas Gonzalez, Jose Manuel Estevez, Wen‐Xue Li, Xing Wang Deng   +8 more
wiley   +1 more source

Revealing Further Insights on Chilling Injury of Postharvest Bananas by Untargeted Lipidomics

Foods, 2020
Chilling injury is especially prominent in postharvest bananas stored at low temperature below 13 °C. To elucidate better the relationship between cell membrane lipids and chilling injury, an untargeted lipidomics approach using ultra-performance liquid ...
Juan Liu, Qingxin Li, Junjia Chen, Yueming Jiang   +3 more
doaj   +1 more source

Mg2+-driven selection of natural phosphatidic acids in primitive membranes

Biological membranes are composed of phospholipids comprising exclusively glycerol-1-phosphate or glycerol-3- phosphate. By contrast, primitive membranes would have been composed of heterogeneous mixtures of phospholipids, including non-natural analogues
Valeria J., Boide-Trujillo, David A., Russell, Krishnakavya, Thaipurayil Madanan, Yuhan, Li, Claudia, Bonfio   +4 more
core   +1 more source

Phosphatidic acid as a limiting host metabolite for the proliferation of the microsporidium Tubulinosema ratisbonensis in Drosophila flies [PDF]

, 2019
International audienceMicrosporidia are located at the base of the fungal evolutionary tree. They are obligate intracellular parasites and harness host metabolism to fuel their growth and proliferation.
Franchet, A. (Adrien), Niehus, Sebastian, Niehus, S. (Sebastian), Ferrandon, D. (Dominique), Franchet, Adrien, Caravello, Gaëtan, Caravello, G. (Gaëtan), Ferrandon, Dominique   +7 more
core   +1 more source

Proteomic Profiling of Myofiber Repair Annexins and Their Role in Duchenne Muscular Dystrophy

PROTEOMICS, EarlyView.
ABSTRACT Myofiber regeneration and membrane repair play crucial roles in maintaining the continuous physiological functioning of the neuromuscular system. A swift and efficient repair mechanism enables the rapid restoration of sarcolemmal integrity following cellular impairment in damaged skeletal muscles.
Paul Dowling, Dounia Bouragba, Elisa Negroni, Capucine Trollet, Margit Zweyer, Dieter Swandulla, Kay Ohlendieck   +6 more
wiley   +1 more source

Comprehensive DIA‐MS Proteomics of Root Basal Nodes Elucidates Mechanisms of Salt Tolerance in Rice

PROTEOMICS, EarlyView.
ABSTRACT Soil salinity severely affects rice growth, yield, and quality, posing a global food security challenge. Rice is particularly vulnerable to high salinity, which restricts growth and tolerance to other stresses. To address this, breeding efforts have been made in the past, leading to the generation of multi‐stress‐tolerant rice lines.
Cheol Woo Min, Choonseok Lee, Ravi Gupta, Gi Hyun Lee, Ji Soo Kim, Na Won Park, Joong Hyoun Chin, Ki‐Hong Jung, Sun Tae Kim   +8 more
wiley   +1 more source

Selective incorporation of various C-22 polyunsaturated fatty acids in Ehrlich ascites tumor cells.

Journal of Lipid Research, 1990
Three 14C-labeled 22-carbon polyunsaturated fatty acids, 7,10,13,16-[14C]docosatetraenoic acid (22:4(n-6)), 7,10,13,16,19-[14C]docosapentaenoic acid (22:5(n-3)), and 4,7,10,13,16,19-[14C]docosahexaenoic acid (22:6(n-3)), were compared with [3H ...
Y Masuzawa, S Okano, K Waku, H Sprecher, W E Lands   +4 more
doaj   +1 more source

x‐Ray Structure of Streptomyces avermitilis Phospholipase D Reveals a Ca2+‐Stabilized Expanded Active‐Site Cleft Adapted for Phospholipid Binding

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Phospholipase D (PLD) catalyzes the hydrolysis of phospholipids to generate phosphatidic acid and free head groups such as choline. Among bacterial PLD enzymes, Streptomyces chromofuscus PLD (SchPLD), a member of the alkaline phosphatase D (PhoD) superfamily, exhibits unique Ca2+‐dependent phospholipase activity.
Yoshiaki Yasutake, Tatsuya Hirata, Shunsuke Nomura, Kenji Konishi, Kazunari Yoneda, Shin‐ichi Sakasegawa, Haruhiko Sakuraba   +6 more
wiley   +1 more source