Results 91 to 100 of about 18,012 (195)

The Mitotic and Metabolic Effects of Phosphatidic Acid in the Primary Muscle Cells of Turbot (Scophthalmus maximus)

Frontiers in Endocrinology, 2018
Searching for nutraceuticals and understanding the underlying mechanism that promote fish growth is at high demand for aquaculture industry. In this study, the modulatory effects of soy phosphatidic acids (PA) on cell proliferation, nutrient sensing, and
Tingting Wang, Tingting Wang, Xuan Wang, Xuan Wang, Huihui Zhou, Huihui Zhou, Haowen Jiang, Haowen Jiang, Kangsen Mai, Kangsen Mai, Gen He, Gen He, Gen He   +12 more
doaj   +1 more source

Mitochondrial membrane remodeling in stress adaptation: Lipid control of organelle quality

Protein Science, Volume 35, Issue 8, August 2026.
Abstract Mitochondria respond to proteotoxic stress through the mitochondrial unfolded protein response, traditionally viewed as a transcriptional program that restores proteostasis by inducing chaperones and proteases. Emerging evidence indicates that mitochondrial membrane remodeling constitutes an additional adaptive component of this response ...
Lena J. Reichert, F.‐Nora Vögtle, Carlotta Peselj   +2 more
wiley   +1 more source

Adolescent Dietary Supplementation of Omega‐3 Polyunsaturated Fatty Acids Alleviates PTSD‐Like Fear Memory and Affective Dysregulation in Rats

Smart Medicine, Volume 5, Issue 4, August 2026.
Adolescent omega‐3 polyunsaturated fatty acid supplementation enhances resilience to trauma in adulthood. DHA/EPA intake restores gut microbial balance, reprograms lipid metabolism, and normalizes prefrontal PI3K/AKT/mTOR signaling. These changes may collectively mitigate PTSD‐like fear memory and affective dysregulation. ABSTRACT Post‐traumatic stress
Wenjing Li, Yi Yin, Jie Li, Ziwei Yao, Siqi Wang, Yinan Jin, Lihua Bian, Jianyou Guo   +7 more
wiley   +1 more source

Opposing roles of DGAT‐mediated lipid droplet biogenesis in the regulation of ferroptosis sensitivity

The FEBS Journal, Volume 293, Issue 15, Page 4508-4532, August 2026.
Ferroptosis is driven by unrestricted peroxidation of polyunsaturated fatty acyl (PUFA) chains in membrane phospholipids. In triple‐negative breast cancer cells, lipid droplets (LDs) sequester dietary PUFAs, limiting their incorporation into membrane phospholipids, preventing mitochondrial damage, and reducing lipid peroxidation and ferroptosis.
Ana Kump, Leja Perne, Špela Koren, Eva Jarc Jovičić, Nastja Feguš, Carina Pinto Kozmus, Michele Wölk, Kristyna Brejchova, Maria Fedorova, Ondrej Kuda, Toni Petan   +10 more
wiley   +1 more source

Decoding MAPK cascades in plant immunity: Activation, regulation, integration, and pathogen manipulation

Journal of Integrative Plant Biology, Volume 68, Issue 8, Page 3000-3024, August 2026.
This review focuses on mitogen‐activated protein kinase (MAPK) activation and summarizes how plants regulate and integrate MAPK signaling in modulating plant immune responses. It also examines the effectors pathogens have evolved to manipulate MAPK activation and thereby inhibit plant immunity.
Guitao Zhong, Zhanchun Wang, Dingzhong Tang, Wei Wang   +3 more
wiley   +1 more source

Plant G proteins: Versatile signaling hubs for synergistic improvement of agronomic traits

Journal of Integrative Plant Biology, Volume 68, Issue 8, Page 3133-3152, August 2026.
This review highlights the roles of G‐protein signaling in crop yield and quality, as well as abiotic and biotic stress responses. It also discusses the feasibility of breaking the trade‐off between plant growth and stress tolerance via dissecting G‐protein regulatory pathways, gene editing, mining natural elite variants, and AI‐assisted breeding ...
Haoran Li, Zhilong Zhang, Fangyuan Liu, Haonan Wang, Zebiao He, Sanyuan Tang, Xiaojing Dong, Peng Xie   +7 more
wiley   +1 more source

Genomic and Physiological Insights Into Heat–Drought Tolerance in Wheat Through GWAS and Phenotypic Evaluation

Plant, Cell &Environment, Volume 49, Issue 8, Page 5511-5529, August 2026.
ABSTRACT Climate change‐driven heat and drought stresses during reproductive stages significantly threaten wheat productivity. To investigate the genetic and physiological basis of combined heat–drought (HD) tolerance, we evaluated 345 wheat genotypes under three environments of HD stresses, non‐stress glasshouse conditions and a late‐sowing field ...
Jingjuan Zhang, Weinan Xu, Rakshith S. R. Gowda, Joel Johnstone, Malona Alinsug, Abhishek Bohra, Vanika Garg, Annapurna Chitikineni, Dion Bennett, Meixue Zhou, Meiqin Lu, Chengdao Li, Zhong‐Hua Chen, Reyazul Rouf Mir, Rajeev K. Varshney   +14 more
wiley   +1 more source

Phospholipase PLA2G16 Accelerates the Host Interferon Signaling Pathway Response to FMDV

Viruses
PLA2G16 is a member of the phospholipase A2 family that catalyzes the generation of lysophosphatidic acids (LPAs) and free fatty acids (FFAs) from phosphatidic acid. Previously, PLA2G16 was found to be a host factor for picornaviruses.
Bingjie Sun, Xiaodong Qin, Taoqing Zhang, Sujie Dong, Yinbo Ye, Changying Wang, Yan Zhang, Rongzeng Hao, Yi Ru, Hong Tian, Haixue Zheng   +10 more
doaj   +1 more source

Synthesis of phosphatidic acids via cobalt(salen) catalyzed epoxide ring-opening with dibenzyl phosphate.

Org Biomol Chem, 2022
Andringa RLH, Jonker M, Minnaard AJ.
europepmc   +1 more source

Saturated phosphatidic acids mediate saturated fatty acid-induced vascular calcification and lipotoxicity. [PDF]

J Clin Invest, 2015
Masuda M, Miyazaki-Anzai S, Keenan AL, Okamura K, Kendrick J, Chonchol M, Offermanns S, Ntambi JM, Kuro-O M, Miyazaki M.   +9 more
europepmc   +1 more source