Results 121 to 130 of about 114,039 (255)
BMEMat, EarlyView.Redox‐responsive lipid‐mimetic prodrug liposomes with high drug‐to‐lipid ratios enhance cabazitaxel delivery, prolong circulation, and enable tumor‐selective drug release for superior antitumor efficacy and safety. Abstract Liposomes represent one of the most extensively investigated nanocarriers in drug delivery.
Shengyao Xu +16 more
wiley +1 more source
A bioinspired catalytic nanoplatform for ferroptosis‐immunotherapy synergy in metastatic cancer
BMEMat, EarlyView.The bioinspired nanoplatform MnMSN@MnP‐PEG co‐delivers manganese peroxidase and manganese ions to synergistically induce immunogenic ferroptosis and activate the cGAS‐STING pathway, eliciting potent antitumor immunity against primary and metastatic tumors.
Panpan Xue +8 more
wiley +1 more source
Mitigation of surfactant erythrocyte toxicity by egg phosphatidylcholine
, 2000 Polyoxyethylene alkyl ether surfactants have been shown to have excellent penetration enhancing abilities although they are associated with a high level of local toxicity. We have compared the toxicity of a range of polyoxyethylene alkyl ethers (Brij 96,
Brown, Marc B. +9 more
core +1 more source
BMEMat, EarlyView.Plant‐derived extracellular vesicles offer numerous advantages and are regarded as highly promising candidates in the field of biomedicine. Abstract Extracellular vesicles (EVs) are double‐membrane vesicular structures that can be secreted by nearly all living cells.
Zilin Li +6 more
wiley +1 more source
Acemetacin–phosphatidylcholine interactions are determined by the drug ionization state
, 2018 Complementary biophysical techniques depicted the differential effects of acemetacin ionic forms on phosphatidylcholine bilayers.
Débora Grahl +7 more
core +1 more source
BMEMat, EarlyView.This review systematically summarizes the major molecular mechanisms governing TAM polarization and their coordinated interactions. It further highlights recent advances in nanoagonist‐based strategies that intervene in these pathways to reprogram TAMs, critically discussing their therapeutic potential, current limitations, and translational prospects.
Siqi Fang +7 more
wiley +1 more source
A Green Protocol for the Deprotection of ortho‐Nitrobenzyl Esters and Ethers by UVA–LED Irradiation
Chemistry – A European Journal, EarlyView.This study presents a green and efficient photochemical protocol for the deprotection of ortho‐nitrobenzyl esters or ethers under mild conditions, using UVA‐LED irradiation in methanol. The broad applicability of the protocol was validated in the synthesis of a cytosolic phospholipase A2 inhibitor. ABSTRACT The removal of protecting groups in synthetic
Despoina Poikilidou +3 more
wiley +1 more source
Phosphatidylcholine/sphingomyelin metabolism crosstalk inside the nucleus
, 2008 International audienceIt is known that the phospholipids represent a "minor component" of chromatin. Recently it has been highlighted that these lipids are metabolised directly inside the nucleus thanks to the presence of the enzymes related to their ...
Lazzarini, Remo +2 more
core +1 more source
Transcriptomic Profiling of SLC and ABC Transporters in the Human Term Placenta
Clinical Pharmacology &Therapeutics, EarlyView.Solute carriers (SLC) and ATP‐binding cassette (ABC) transporters are essential for placental solute exchange and fetal protection, yet their transcriptomic profiles in the human placenta remain poorly characterized. Although fetal sex influences placental development and function, its impact on transporter expression is unclear.
Elijah Marsh Jung +12 more
wiley +1 more source
Drug Testing and Analysis, EarlyView.This proof‐of‐concept study evaluated the impact of short‐distance drone transport on anti‐doping sample integrity compared with traditional car transport. Targeted assays and untargeted metabolomics revealed equivalent biological profiles between methods, confirming that drone delivery preserves sample integrity for the athlete biological passport ...
I. Al‐Mohannadi +13 more
wiley +1 more source