Results 51 to 60 of about 74,308 (377)

Miscibility of Phosphatidylcholines in Bilayers: Effect of Acyl Chain Unsaturation

Membranes, 2023
The miscibility of phospholipids in a hydrated bilayer is an issue of fundamental importance for understanding the organization of biological membranes. Despite research on lipid miscibility, its molecular basis remains poorly understood.
Agata Żak, Natan Rajtar, Waldemar Kulig, Mariusz Kepczynski   +3 more
doaj   +1 more source

Syntheses and cytotoxicity of phosphatidylcholines containing ibuprofen or naproxen moieties

Scientific Reports, 2019
In this study, novel phosphatidylcholines containing ibuprofen or naproxen moieties were synthesized in good yields and high purities. Under the given synthesis conditions, the attached drug moieties racemized, which resulted in the formation of ...
Marek Kłobucki, A. Urbaniak, A. Grudniewska, Bartłomiej Kocbach, G. Maciejewska, Grzegorz Kiełbowicz, M. Ugorski, C. Wawrzeńczyk   +7 more
semanticscholar   +1 more source

Sets of coregulated serum lipids are associated with Alzheimer's disease pathophysiology [PDF]

, 2019
Introduction: Comorbidity with metabolic diseases indicates that lipid metabolism plays a role in the etiology of Alzheimer's disease (AD). Comprehensive lipidomic analysis can provide new insights into the altered lipid metabolism in AD.
Arnold, Matthias, Baillie, Rebecca, Barupal, Dinesh Kumar, Consortium, Alzheimer Disease Metabolomics, Fan, Sili, Fiehn, Oliver, Initiative, Alzheimer's Disease Neuroimaging, Kaddurah‐Daouk, Rima, Meikle, Peter J, Nho, Kwangsik, Saykin, Andrew J   +10 more
core   +2 more sources

Deletion of TSPO resulted in change of metabolomic profile in retinal pigment epithelial cells [PDF]

, 2019
Age-related macular degeneration is the main cause of vision loss in the aged population worldwide. Drusen, extracellular lesions formed underneath the retinal pigment epithelial (RPE) cells, are a clinical feature of AMD and associated with AMD ...
Abdulwahab Alamri, David Watson, Farooqui, Lincoln Biswas, Rohrer, Suzuki, Winkler, Xinhua Shu   +7 more
core   +2 more sources

Functional, transcriptomic, and lipidomic studies of the choC gene encoding a phospholipid methyltransferase in Aspergillus fumigatus

Microbiology Spectrum
Phosphatidylcholines (PCs) are a class of cell membrane phospholipids playing important roles in cellular integrity and signaling. In eukaryotes, PCs are biosynthesized via the Kennedy cytidine nucleotide and the Bremer-Greenberg pathways.
Jiao Pan, Xinyu Yang, Cuiting Hu, Tongtong Fu, Xiuyan Zhang, Zijun Liu, Yu Wang, Fengyu Zhang, Xiaoyuan He, Jae-Hyuk Yu   +9 more
doaj   +1 more source

Anti-inflammatory Effects of Phosphatidylcholine [PDF]

Journal of Biological Chemistry, 2007
We recently showed that mucus from patients with ulcerative colitis, a chronic inflammatory disorder of the colon, is characterized by a low level of phosphatidylcholine (PC) while clinical studies reveal that therapeutic addition of PC using slow release preparations is beneficial. The positive role of PC in this disease is still elusive.
Treede, Irina, Braun, Annika, Sparla, Richard, Kuehnel, Mark, Giese, Thomas, Turner, Jerrold R., Anes, Elsa, Kulaksiz, Hasan, Fuellekrug, Joachim, Stremmel, Wolfgang, Griffiths, Gareth, Ehehalt, Robert   +11 more
openaire   +4 more sources

Plasma lipidomic and metabolomic profiles in high‐grade glioma patients before and after 72‐h presurgery water‐only fasting

Molecular Oncology, EarlyView.
Presurgery 72‐h fasting in GB patients leads to adaptations of plasma lipids and polar metabolites. Fasting reduces lysophosphatidylcholines and increases free fatty acids, shifts triglycerides toward long‐chain TGs and increases branched‐chain amino acids, alpha aminobutyric acid, and uric acid.
Iris Divé, Lisa Hahnefeld, Katharina J. Wenger, Donat Kögel, Joachim Steinbach, Gerd Geisslinger, Michael W. Ronellenfitsch, Irmgard Tegeder   +7 more
wiley   +1 more source

Time‐Controlled Dual Targeting to Program Systemic and Intercellular Transfer of Therapeutic Effects

Advanced Functional Materials, EarlyView.
Aspirin‐liposomes loaded onto monocytes enable inflammation‐triggered targeting and efficient hand‐over of aspirin to inflamed cells. Monocytes uptake a significant portion of aspirin‐liposomes, prolonging therapeutic action. This approach enhances anti‐inflammatory effects through intercellular transfer, demonstrating a translational strategy for ...
Seung Eun Yu, Jueun Kim, Dae‐Hyun Kim, Sewoom Baek, Suji Park, Seyong Chung, Hak‐Joon Sung   +6 more
wiley   +1 more source

Effect of phospholipids and bile acids on cholesterol nucleation time and vesicular/micellar cholesterol in gallbladder bile of patients with cholesterol stones [PDF]

, 1993
Supersaturation and rapid nucleation of cholesterol in bile are of key importance in the pathogenesis of cholesterol gallstones. While the effects of bile acids and phospholipids on cholesterol saturation of bile have been extensively studied, their ...
Huber, P., Jüngst, Dieter, Lang, Thomas, Lange, V., Paumgartner, Gustav   +4 more
core  

Viscosity of phosphatidylcholine (lecithin)

Journal of Pharmacy and Pharmacology, 1966
AbstractThe viscosities of egg lecithin dispersed in water have been measured by means of a Couette viscometer. The more concentrated dispersions are thixotropic, but below 1·8% w/w of lecithin the sols become Newtonian. From the extrapolated ratio of specific viscosity to volume fraction, the dispersed particles are considered to be of an elongated ...
J. Perrin, L. Saunders
openaire   +3 more sources