Results 81 to 90 of about 3,448 (206)

Fatty acid ethyl esters induce intestinal epithelial barrier dysfunction via a reactive oxygen species-dependent mechanism in a three-dimensional cell culture model.

PLoS ONE, 2013
Background & aimsEvidence is accumulating that ethanol and its oxidative metabolite, acetaldehyde, can disrupt intestinal epithelial integrity, an important factor contributing to ethanol-induced liver injury. However, ethanol can also be metabolized non-
Elhaseen Elamin, Ad Masclee, Kati Juuti-Uusitalo, Sven van Ijzendoorn, Freddy Troost, Harm-Jan Pieters, Jan Dekker, Daisy Jonkers   +7 more
doaj   +1 more source

Blood Transfusions and Elevated Serum Phosphatidylethanol: Implications for Liver Transplant Eligibility: A Case Report

Journal of Clinical Question
Background: Phosphatidylethanol (PEth) is a specific biomarker for alcohol consumption that reflects intake over weeks rather than days, making it valuable for assessing long-term abstinence and liver transplant eligibility in patients with alcoholic ...
Trevor Short, Olivia Wu, Gary Chu
doaj   +1 more source

Cannabidiol and cannabigerol ameliorate steatotic liver disease via phosphocreatine buffering and lysosomal restoration

British Journal of Pharmacology, Volume 183, Issue 12, Page 3173-3194, June 2026.
Cannabidiol (CBD) and cannabigerol (CBG) alleviate hepatic steatosis in obese mice by shifting energy buffering towards phosphocreatine and enhancing lysosomal lipid degradation and trafficking. These effects are associated with increased creatine kinase activity and lysobisphosphatidic acid (LBPA) levels, highlighting a previously unrecognised ...
Radka Kočvarová, Shahar Azar, Bella Agranovich, Ifat Abramovich, Saveliy Kirillov, Alina Nemirovski, Saja Baraghithy, Inbar Plaschkes, Emmanuelle Merquiol, Alexander Rouvinski, Galia Blum, Liad Hinden, Joseph Tam   +12 more
wiley   +1 more source

Characterizing the relationship between phosphatidylethanol (PEth) concentrations and liver fibrosis

, 2023
Alcohol use is one of the most common causes of liver fibrosis, yet accurately self-reporting use is challenging for many, due to both social desirability and recall bias.
Bronwyn Myers, Kaku So-Armah, Gabriel Chamie, Pam Murnane, Judith Hahn, Winnie Muyindike, Veronica L Richards, Tekeda Ferguson, Lamia Haque, Evgeny Krupitsky, Mandana Khalili, Majid Afshar, Karen Jabobsen, Amy C Justice, Mark Sulkowski, Patricia Molina, Theresa W. Kim, David Welsh, Robert L Cook, Scott H Stewart, Kathleen McGinnis   +20 more
core   +1 more source

Effects of Norepinephrine and Cardiotrophin-1 on Phospholipase D Activity and Incorporation of Myristic Acid Into Phosphatidylcholine in Rat Heart

Journal of Pharmacological Sciences, 2004
The present study is part of a project on phospholipase D (PLD) in cardiac hypertrophy and analyzed effects on PLD activity of two growth stimuli, norepinephrine (NE) and cardiotrophin-1 (CT-1), in incubated rat heart.
Tobias Weismüller, Jochen Klein, Konrad Löffelholz   +2 more
doaj   +1 more source

GLP‐1 Receptor Agonists for Treating Alcohol Use Disorder: A Critical Review

Alcohol, Clinical and Experimental Research, Volume 50, Issue 5, May 2026.
This narrative review of the development of GLP‐1 receptor agonists provides a foundation for both preclinical and clinical research on their use for treating alcohol use disorder (AUD). Both observational studies using real‐world data and randomized controlled clinical trials support the potential utility of these medications for treating AUD ...
Sean Woo, Grace Zhu, Chrismely Castro, Allen Phuong, Aadita Roy, Christal N. Davis, Henry R. Kranzler   +6 more
wiley   +1 more source

A Membrane‐Centric Plasma Lipidomic Signature of Response to Long‐Acting Naltrexone in Alcohol Use Disorder

Addiction Biology, Volume 31, Issue 5, May 2026.
In this responder‐enriched lipidomic substudy, response to long‐acting naltrexone in alcohol use disorder was associated with coordinated remodelling of plasma membrane phospholipids. The signature involved PEMT‐related PC/PE shifts, Lands‐cycle acyl chain editing, and cross‐headgroup redistribution of n‐3 PUFAs and arachidonic acid, defining a ...
Liyao Huang, Bojie Zhou, Qinling Ou, Jubo Yin, Xiwen Tian, Xuhui Zhou   +5 more
wiley   +1 more source

Increasing phospholipid biomimicry governs water permeability in droplet interface bilayers

Droplet, Volume 5, Issue 2, April 2026.
Increasing phospholipid biomimicry in droplet interface bilayers alters how membranes respond to “membrane‐active molecules” such as cholesterol and niacin. This shows that membranes made using synthetic lipids can overestimate small‐molecule effects, highlighting the importance of using biomimetic lipid compositions to improve physiological relevance ...
Alejandro Forigua, Katherine S. Elvira
wiley   +1 more source

Interlaboratory comparison of phosphatidylethanol in dried blood spots using different sampling devices. [PDF]

Phosphatidylethanol (PEth) has become an important marker to assess drinking behaviour and monitor abstinence. Despite its increasing use, knowledge on robustness and standardization and comparability of methods and results are still limited.
Weinmann, Wolfgang, Stöth, Frederike, Luginbühl, Marc, Bantle, Matthias   +3 more
core   +2 more sources

Association between alcohol use and inflammatory biomarkers over time among younger adults with HIV-The Russia ARCH Observational Study.

PLoS ONE, 2019
BackgroundBiomarkers of monocyte activation (soluble CD14 [sCD14]), inflammation (interleukin-6 [IL-6]), and altered coagulation (D-dimer) are associated with increased mortality risk in people with HIV.
Kaku A So-Armah, Debbie M Cheng, Matthew S Freiberg, Natalia Gnatienko, Gregory Patts, Yicheng Ma, Laura White, Elena Blokhina, Dmitry Lioznov, Margaret F Doyle, Russell P Tracy, Natalie Chichetto, Carly Bridden, Kendall Bryant, Evgeny Krupitsky, Jeffrey H Samet   +15 more
doaj   +1 more source