Results 61 to 70 of about 3,564 (210)

Evaluating the Impact of Phosphatidylethanol Testing on Hospital Outcomes

Gastroenterology Research
Alcohol dependence remains a significant global health issue, exacerbated by the coronavirus disease 2019 (COVID-19) pandemic. Phosphatidylethanol (PEth), a direct biomarker of recent alcohol consumption, offers improved specificity, sensitivity, and a longer detection window of 2 - 4 weeks compared to traditional biomarkers.
Haddadin, Rakahn, Molina, Steven, Trad, George, Ryan, John, Gish, Robert   +4 more
openaire   +2 more sources

Acute exercise‐induced lipolysis and increase in levels of fatty acid esters of hydroxy fatty acids in adipose tissue are impaired in obese and aged mice

Experimental Physiology, Volume 111, Issue 10, Page 4457-4497, 1 October 2026.
Abstract Improving adipose tissue (AT) metabolism through exercise might increase production of lipokines from the fatty acid esters of hydroxy fatty acids (FAHFA) family. Although exercise training can increase insulin sensitivity and levels of specific FAHFA in AT and the circulation in humans, the effects of acute exercise on FAHFA levels remain ...
Marko Mitrovic, Olga Horakova, Martin Riecan, Veronika Kleinova, Tomas Cajka, Lenka Rossmeislova, Ondrej Kuda, Martin Rossmeisl   +7 more
wiley   +1 more source

A false positive hair ethylglucuronide dosage in an alcohol abstinent patient after liver transplantation: a case report

Frontiers in Medicine
The use of direct alcohol biomarkers (ethylglucuronide and phosphatidylethanol) has recently been implemented in a clinical setting. Due to their low alcohol detection threshold, high sensitivity, and specificity, these tools are very useful in the pre ...
Thierry Favrod-Coune, Déborah Lidsky, Julien Vionnet, Giulia Magini, Julien Déglon, Barbara Broers   +5 more
doaj   +1 more source

Prevalence of Alcohol Consumption in Emergency department presentations (PACE) in Queensland, Australia, using alcohol biomarkers ethanol and phosphatidylethanol: an observational study protocol

BMJ Open, 2021
Introduction Alcohol use in patients presenting to the emergency department (ED) is a significant problem in many countries. There is a need for valid and reliable surveillance of the prevalence of alcohol use in patients presenting to the ED, to provide
Tegwen Howell, Jacelle Warren, Cate M Cameron, Kirsten Vallmuur, Victoria McCreanor, Gary Mitchell, Silvia Manzanero, Michael Schuetz, Kim A Vuong, Jacobus P J Ungerer, Brett McWhinney, Clifford Pollard, Anna Zournazi   +12 more
doaj   +1 more source

Multi‐tissue Metabolic GWAS and Drought‐Responsive Multi‐omics Reveal the Genetic Basis of the Quinoa Metabolome

Advanced Science, Volume 13, Issue 54, 28 September 2026.
A multi‐omics framework combining multitissue genome‐wide association studies, metabolomics, transcriptomics, proteomics, and functional validation uncovers the genetic basis of specialized metabolism in quinoa. The study identifies hundreds of metabolite‐associated loci, prioritizes candidate genes for saponin, betalain, and flavonoid biosynthesis ...
Julia von Steimker, Elodie L. Rey, Clara Stanschewski, Regina Wendenburg, Annabella Klemmer, Markéta Macho, Venkatesh P. Thirumalaikumar, Noha O. Saber, Aleksandra Skirycz, Alisdair R. Fernie, Mark Tester, Saleh Alseekh   +11 more
wiley   +1 more source

ALDH2 Polymorphism in Alcohol‐Related Cirrhosis Requiring Liver Transplantation: A Recipient–Donor Analysis

Hepatology Research, Volume 56, Issue 9, Page 1419-1425, September 2026.
ABSTRACT Aim Genetic polymorphisms of alcohol‐metabolizing enzymes influence drinking behavior and susceptibility to alcohol‐related liver disease (ALD). This study aimed to clarify the distribution of ALDH2 and ADH1B genotypes in liver transplant recipients with ALD, and to explore associations with post‐transplant drinking behavior using a recipient ...
Noriyo Yamashiki, Yoshihide Ueda, Takashi Ito, Etsuro Hatano   +3 more
wiley   +1 more source

Protein kinase Cζ regulates phospholipase D activity in rat-1 fibroblasts expressing the α_1A adrenergic receptor

BMC Cell Biology, 2004
Background Phenylephrine (PHE), an α1 adrenergic receptor agonist, increases phospholipase D (PLD) activity, independent of classical and novel protein kinase C (PKC) isoforms, in rat-1 fibroblasts expressing α1A adrenergic receptors.
Bourgoin Sylvain G, Malik Kafait U, Saeed Abdelwahab E, Wiggins Monique T, Gandhi Gautam K, Parmentier Jean-Hugues   +5 more
doaj   +1 more source

Phosphatidylethanol and ethyl glucuronide to categorize alcohol consumption in alcohol-related cirrhosis

JHEP Reports
Background & Aims: Phosphatidylethanol (PEth) is an alcohol-use biomarker that could bridge the detection windows of urinary ethyl glucuronide (uEtG) and scalp hair ethyl glucuronide (hEtG), but has been rarely validated in patients with liver ...
Benedict T.K. Vanlerberghe, Catalina Dumitrascu, Nele Van den Eede, Hugo Neels, Hannah van Malenstein, Tom J.G. Gevers, Matthijs Kramer, Lukas Van Melkebeke, Ad A.M. Masclee, Douwe de Boer, Schalk van der Merwe, Frederik Nevens, Alexander L.N. van Nuijs, Jef Verbeek   +13 more
doaj   +1 more source

Phosphatidylethanol Levels in Postpartum Women and Their Newborns in Uruguay and Brazil

Alcoholism: Clinical and Experimental Research, 2020
BackgroundThere is increasing interest in the development of newborn screening tests to identify children at risk of fetal alcohol spectrum disorder (FASD) in order to provide these children with early intervention. Phosphatidylethanol (PEth) has emerged as a potential universal newborn screening candidate.MethodsThe aim of this report was to present ...
Aileen E. Baldwin, Nicole Hayes, Erika Ostrander, Raquel Magri, Nelson Sass, Maria dos Anjos Mesquita, Monica Martínez, Monica Correa Juliani, Pablo Cabral, Michael Fleming   +9 more
openaire   +3 more sources

Identifying excessive chronic alcohol use with phosphatidylethanol in patients with suspected severe injury-results from the IDART study [PDF]

Introduction: Acute and chronic alcohol use are well-known risk factors for accidents and injuries, and concurrent psychoactive drug use can increase injury risk further.
Steinson Stenehjem, Jo, Bråthen, Camilla Christin, Jørgenrud, Benedicte Marie, Rosseland, Leiv Arne, Kristiansen, Thomas, Bogstrand, Stig Tore   +5 more
core   +1 more source