Results 91 to 100 of about 79,723 (288)

Membrane‐Active Peptide Protects Against Inflammation by Targeting NLRP3 Activation at the Trans‐Golgi Network

Advanced Science, EarlyView.
The membrane‐active peptide Pep19‐2.5 reduces harmful inflammation by blocking activation of the NLRP3 inflammasome at trans‐Golgi network membranes. By targeting key membrane interactions, Pep19‐2.5 suppresses inflammatory IL‐1β production and alleviates allergic airway inflammation in mice, leading to reduced immune cell infiltration and improved ...
Jonas Engelhardt, Nico Kirsch, Aileen Kerfin, Lars P. Lunding, Dominic Ferber, Hannes Buthmann, Ilka Schreier, Carlotta Bosio, Ann‐Kathrin Dobbelstein, Anna Klawonn, Rebecca C. Coll, Lena Bauernhofer, Sandro Keller, Matthias Geyer, Michael Wegmann, Andra B. Schromm, Günther Weindl   +16 more
wiley   +1 more source

Impaired de novo choline synthesis explains why phosphatidylethanolamine N-methyltransferase-deficient mice are protected from diet-induced obesity [PDF]

, 2010
Phosphatidylcholine (PC) is synthesized from choline via the CDP-choline pathway. Liver cells can also synthesize PC via the sequential methylation of phosphatidylethanolamine, catalyzed by phosphatidylethanolamine N-methyltransferase (PEMT). The current
Jacobs, René L., Kennedy, Brian P., Sletten, Torunn, Kuo, Ming-Shang, Su, Brian, Peake, David A., Koonen, Debby P. Y., Dyck, Jason R. B., Cao, Guoqing, Zhao, Yang, Vance, Dennis E., Lingrell, Susanne, Proctor, Spencer D.   +12 more
core   +1 more source

High‐Density E. Coli Cultivation Arrays for Combinatorial Drug Testing With Subsequent Lipid Profiling by MALDI‐MS

Advanced Science, EarlyView.
High‐throughput antibiotic cross‐gradient assays on microdroplet arrays. A multichannel printhead together with five pressure regulators forms droplet arrays of up to 20 832 droplets within 25 minutes. Each droplet contains unique concentrations of antibiotics, allowing to moniture a vast spectrum of bacterial repsonses over night. The bacterial growth
M. Breitfeld, C. L. Dietsche, F‐L. Born, I. Onipko, L. Blaase, P. S. Dittrich   +5 more
wiley   +1 more source

Comparison of erythrocyte membrane phosphatidylethanolamine lipids levels according to dominance of positive or negative symptoms. [PDF]

, 2016
Comparison of erythrocyte membrane phosphatidylethanolamine lipids levels according to dominance of positive or negative symptoms.
Jae-Min Kim (112584), Min Jhon (2559721), Stefan Smesny (2136697), Michael Berk (343706), Sung-Wan Kim (112587), Claudia M. Klier (2136712), G. Paul Amminger (2136709), Simon Rice (2559718), Miriam R. Schäfer (2136718), Patrick D. McGorry (717772)   +9 more
core   +1 more source

Turnover of nonessential fatty acids in cardiolipin from the rat heart

Journal of Lipid Research, 2011
Cardiolipin (CL) is a unique phospholipid (PL) found in the mitochondria of mammalian cells. CL remodeling is accompanied by turnover of its fatty acid acyl groups. Abnormalities in CL remodeling have been found in Barth's syndrome, diabetes, and obesity.
Paulin N. Wahjudi, Jennifer K. Yee, Steven R. Martinez, Jin Zhang, Michael Teitell, Liana Nikolaenko, Ronald Swerdloff, Christina Wang, W.N. Paul Lee   +8 more
doaj   +1 more source

Metabolic Profiling of Plasma in Different Calving Body Condition Score Cows Using an Untargeted Liquid Chromatography-Mass Spectrometry Metabolomics Approach

Animals, 2020
This study was undertaken to identify metabolite differences in plasma of dairy cows with a normal or high calving body condition score (CBCS), using untargeted liquid chromatography-mass spectrometry (LC-MS) metabolomics.
Jian Wang, Chuang Zhang, Qingyao Zhao, Congcong Li, Shuang Jin, Xianhong Gu   +5 more
doaj   +1 more source

Rapid Multiplex Antimicrobial Resistance Profiling and Bacterial Identification by LAP‐MALDI Mass Spectrometry Biotyping

Advanced Science, EarlyView.
Liquid atmospheric pressure matrix‐assisted laser desorption/ionization (LAP‐MALDI) mass spectrometry (MS) provides multiplexed biotyping of microbial cultures using a fast and simple workflow. This is demonstrated for clinically relevant bacteria, resulting in accurate antimicrobial resistance (AMR) detection, speciation by MS/MS sequencing and ...
Lily R. Adair, Shabnam Iyer, Ian M. Jones, Rainer Cramer   +3 more
wiley   +1 more source

Minimal system to covalently bind the protein Atg8 via an ubiquitin-like reaction to phosphatidylethanolamine (PE). [PDF]

, 2014
Minimal system to covalently bind the protein Atg8 via an ubiquitin-like reaction to phosphatidylethanolamine (PE).
Roland L. Knorr (178019), Hitoshi Nakatogawa (676830), Reinhard Lipowsky (178033), Yoshinori Ohsumi (228984), Tobias Baumgart (183997), Rumiana Dimova (178026)   +5 more
core   +1 more source

Enzymatic measurement of phosphatidylserine in cultured cells

Journal of Lipid Research, 2012
Phosphatidylserine (PS) is a quantitatively minor membrane phospholipid involved in diverse cellular functions. In this study, we developed a new fluorometric method for measuring PS using combinations of specific enzymes and Amplex Red.
Shin-ya Morita, Sachimi Shirakawa, Yukiko Kobayashi, Keiko Nakamura, Reiko Teraoka, Shuji Kitagawa, Tomohiro Terada   +6 more
doaj   +1 more source

The liver‐brain axis: A multidimensional regulatory network implicated in Alzheimer's disease pathogenesis and clinical implications

Animal Models and Experimental Medicine, EarlyView.
Schematic diagram of the core pathways of the liver‐brain axis in regulating AD. The liver regulates cerebral Aβ deposition, tau phosphorylation, and neuroinflammation through pathways such as metabolic detoxification (urea cycle, ketone body metabolism, glutathione antioxidant system), molecular secretion (APOE, CRP, FGF21, IGF‐1), and Aβ clearance ...
Ning Zhang, Wei Chen, Meng Wang
wiley   +1 more source