Results 81 to 90 of about 71,224 (296)

Alternative Pathway for Methyl Supply through the Coupling of SHMT1 and PEMT to Maintain Astrocytic Homeostasis in Parkinson's Disease

Advanced Science, EarlyView.
In Parkinson's disease, SHMT1 downregulation disrupts its interaction with PEMT in astrocytes, reducing SAM levels. This leads to H3K4me1 hypomethylation and decreased Slc1a2/Glul expression, ultimately exacerbating neuroexcitotoxicity and dopaminergic neuron loss.
Yue‐Han Chen, Rong‐Xin Zhu, Nuo‐Xi Zhang, Ting‐Ting Sun, Xi‐Wei Zhang, Yu‐Jie Zhao, Ben‐Yu He, Hang Yao, Ren‐Hong Du, Lei Cao, Wen‐Bin Zhang, Wei‐Guo Liu, Yun Cai, Cong Wang, Gang Hu, Yao Wei, Yang Liu, Ming Lu   +17 more
wiley   +1 more source

Phosphatidylethanolamine: A key player in lung disease

Clinical and Translational Discovery
Phosphatidylethanolamine (PE) is a pivotal glycerophospholipid that constitutes a significant portion of cellular membranes, playing a crucial role in maintaining membrane fluidity, supporting protein integration, and mediating signal transduction.
Linlin Zhang, Wanxin Duan, Liyang Li
doaj   +1 more source

Can calmodulin bind to lipids of the cytosolic leaflet of plasma membranes?

Open Biology
Calmodulin (CaM) is a ubiquitous calcium-sensitive messenger in eukaryotic cells. It was previously shown that CaM possesses an affinity for diverse lipid moieties, including those found on CaM-binding proteins. These facts, together with our observation
Federica Scollo, Carmelo Tempra, Hüseyin Evci, Miguel Riopedre-Fernandez, Agnieszka Olżyńska, Matti Javanainen, Arunima Uday, Marek Cebecauer, Lukasz Cwiklik, Hector Martinez-Seara, Pavel Jungwirth, Piotr Jurkiewicz, Martin Hof   +12 more
doaj   +1 more source

Islet Amyloid Polypeptide Modelled to Simulate Diabetes Co‐Oligomerized with β‐Amyloid 1‐42 Reproducing the Pathological Cascade of Alzheimer's Disease in Human Cerebral Organoids

Advanced Science, EarlyView.
Human islet amyloid polypeptide (hIAPP) was used to mimic T2DM, and Aβ42‐hIAPP co‐oligomers were delivered into the human mature cerebral organoids (COs), which reproduce typical AD pathology and significant neuronal death more closely resembling that of AD patients.
Jin Yan, Zhimeng Tang, Yanyu Luo, Bin Liu, Xinxin Huang, Jun Wei, Feng Yue   +6 more
wiley   +1 more source

In Vitro Antithrombotic Properties of Salmon (Salmo salar) Phospholipids in a Novel Food-Grade Extract

Marine Drugs, 2019
Marine and salmon polar lipids (PLs) extracted by conventional extractions with non-food-grade solvents (CE-salmon-PLs) possess antithrombotic bioactivities against platelet-activating factor (PAF) and thrombin.
Alexandros Tsoupras, Ronan Lordan, Katie Shiels, Sushanta Kumar Saha, Constantina Nasopoulou, Ioannis Zabetakis   +5 more
doaj   +1 more source

Spatially Resolved Multiomics Reveals Metabolic Remodeling and Autophagy Activation in Adamantinomatous Craniopharyngiomas

Advanced Science, EarlyView.
Multiomics integration analysis reveals the “cystic fluid–tumor cell” metabolic coupling that mediates active choline/ethanolamine uptake of tumor cells from cystic fluid and PC/PE synthesis pathways reprogramming that mediating autophagy pathway activation within ACP. ABSTRACT Adamantinomatous craniopharyngioma (ACP), a benign yet highly recurrent and
Dongting Chen, Yahui Gao, Yulin Wang, Ting Lei, Zheng Qu, Yuhan An, Jiaxu Fu, Xin Li, Fangjun Liu, Yan Li   +9 more
wiley   +1 more source

Solitary and Synergistic Effects of Different Hydrophilic and Hydrophobic Phospholipid Moieties on Rat Behaviors

Pharmaceutics
Glycerophospholipids have hydrophobic and hydrophilic moieties. Previous studies suggest that phospholipids with different moieties have different effects on rodent behavior; however, the relationship between chemical structures and behavioral effects ...
Shuhei Kikuchi, Yugo Iwasaki, Mina Yoshioka, Kodai Hino, Shin-ya Morita, Ryu Tada, Yasuhiro Uchimura, Yoshinori Kubo, Tomoya Kobayashi, Yusuke Kinoshita, Masahiro Hayashi, Yoshio Furusho, Hitoshi Tamiaki, Hiroaki Ishiyama, Minoru Kuroda, Jun Udagawa   +15 more
doaj   +1 more source

Transfer of cholesteryl esters and phospholipids as well as net deposition by microsomal triglyceride transfer protein

Journal of Lipid Research, 2005
Microsomal triglyceride transfer protein (MTP) activity is classically measured using radioactive lipids. We described a simple fluorescence assay to measure its triacylglycerol (TAG) transfer activity.
Paul Rava, Humra Athar, Caroline Johnson, M. Mahmood Hussain   +3 more
doaj   +1 more source

Efficient Preservation of Perishable Fruits by Erasable Metal‐Organic Frameworks

Advanced Science, EarlyView.
This study presents an erasable Pickering emulsion‐based coating stabilized by metal‐organic frameworks. This washable coating significantly extends fruit shelf life by scavenging ethylene and inhibiting foodborne pathogens, offering a sustainable solution for postharvest.
Liying Yang, Jia Kong, Haoran Bai, Xiaojie Wu, Douxin Xiao, Ming Du, Peng Yang, Alideertu Dong   +7 more
wiley   +1 more source

Ethanolamine plasmalogens prevent the oxidation of cholesterol by reducing the oxidizability of cholesterol in phospholipid bilayers

Journal of Lipid Research, 2003
The aims of the present study are to establish an appropriate system for assessing the oxidizability of cholesterol (1111156) in phospholipid (PL) bilayers, and to explore the effect of ethanolamine plasmalogens on the oxidizability of CH with the system,
Ryouta Maeba, Nobuo Ueta
doaj   +1 more source