Results 51 to 60 of about 8,868 (194)

Exercise alters liver mitochondria phospholipidomic profile and mitochondrial activity in non-alcoholic steatohepatitis [PDF]

, 2014
Mitochondrial membrane lipid composition is a critical factor in non-alcoholic steatohepatitis (NASH). Exercise is the most prescribed therapeutic strategy against NASH and a potential modulator of lipid membrane.
Ascensão, António, Domingues, Maria R., Gonçalves, Inês O., Maciel, Elisabete, Magalhães, José, Oliveira, Paulo J., Passos, Emanuel, Rizo, David, Rocha-Rodrigues, Silvia, Santos-Alves, Estela, Torrella, Joan R., Viscor, Ginés   +11 more
core   +1 more source

Higher Increases in Plasma n‐3 Polyunsaturated Fatty Acids Following Fish Oil Supplementation in Postmenopausal Females Compared With Age‐Matched Males

Lipids, EarlyView.
ABSTRACT The effects of fish oil supplementation on omega‐3 (n‐3) polyunsaturated fatty acids, particularly intermediates between eicosapentaenoic acid (EPA, 20:5n‐3) and docosahexaenoic acid (DHA, 22:6n‐3), that may provide valuable metabolic information, have not been fully characterized in older populations.
David C. R. Ku, Insaf Loukil, Annick Vachon, Mélanie Plourde, Adam H. Metherel   +4 more
wiley   +1 more source

Fatty liver and fibrosis in glycine N-methyltransferase knockout mice is prevented by nicotinamide [PDF]

, 2010
Deletion of glycine N-methyltransferase (GNMT) in mice, the main gene involved in liver S-adenosylmethionine (SAMe) catabolism, leads to the hepatic accumulation of this molecule and the development of fatty liver and fibrosis.
Calvisi, Diego F., Embade, Nieves, Esteller Badosa, Manel, Fernández-Ramos, David, Frades, Itziar, Fraga, Mario F., Julve, Josep, Lu, Shelly C, Luka, Zigmund, Martínez Chantar, María, Martínez-López, Nuria, Mato, José M., Rodríguez, Juan, Rodríguez-Millán, Elisabeth, Torres, Luís, Varela-Rey, Marta, Wagner, Conrad, Woodhoo, Aswhin   +17 more
core   +1 more source

Cold‐Induced Lipidomic Remodelling Is Associated With Brown Adipose Tissue Mean Radiodensity in Humans

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims Cold exposure activates brown adipose tissue (BAT) and promotes thermogenic and metabolic adaptations. While BAT activation has been linked to improved cardiometabolic health, how acute cold exposure reshapes the circulating lipidome in humans remains incompletely understood.
Yu Zhang, Borja Martinez‐Tellez, Alida Kindt, Nicolas Drouin, Amy Harms, Thomas Hankemeier, Jonatan R. Ruiz, Lucas Jurado‐Fasoli   +7 more
wiley   +1 more source

Northern cod (Gadus morhua) movement: insights from acoustic telemetry and genomics

Journal of Fish Biology, EarlyView.
Abstract Knowledge of the timing and diversity of fish movements within a commercially exploited stock complex is required to ensure the sustainability of fisheries. Although migration can be driven by environmental factors, genomic mechanisms also play an important role in this complex life‐history trait. The northern cod (Gadus morhua) stock complex,
M. Lisette Delgado, Nicole Smith, Frederick Whoriskey, Steve Devitt, Emilie Novaczek, Corey J. Morris, Tony Kess, Ian Bradbury, Sara Iverson, Paul Bentzen, Daniel E. Ruzzante   +10 more
wiley   +1 more source

Methyltransferases from Ruta graveolens L.: Molecular Biology and Biochemistry [PDF]

, 2005
The common rue, Ruta graveolens L., is an aromatic plant. It contains acridone alkaloids, furoquinolines, coumarins, and numerous volatile compounds with antimicrobial and allelopathic activity.
Burga, Laura, Matern, Ulrich (Prof. Dr.)
core   +1 more source

The Dual Role of Autophagy in Cancer: Mechanisms and Therapeutic Strategies

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Autophagy is a conserved cellular process degrading dysfunctional organelles and protein aggregates to maintain cell homeostasis, and it exhibits context‐dependent duality in cancer. Autophagy functions as a critical tumor‐suppressive mechanism by preventing DNA damage and mutation during tumor initiation.
Xiang‐Zheng Gao, Yuheng Qin, Haoyu Wan, Guang Lu, Han‐Ming Shen   +4 more
wiley   +1 more source

Molecular Dissection of the S-Adenosylmethionine-binding Site of Phosphatidylethanolamine N-Methyltransferase [PDF]

Journal of Biological Chemistry, 2003
Phosphatidylethanolamine N-methyltransferase (PEMT) is a quatrotopic membrane protein that catalyzes the conversion of phosphatidylethanolamine to phosphatidylcholine through three sequential methylation reactions. Analysis of mice lacking a functional PEMT gene revealed a severe reduction in plasma homocysteine levels. Homocysteine is generated by the
David J, Shields, Judith Y, Altarejos, Xu, Wang, Luis B, Agellon, Dennis E, Vance   +4 more
openaire   +2 more sources

Hepatic Choline Transport Is Inhibited During Fatty Acid–Induced Lipotoxicity and Obesity

Hepatology Communications, 2020
Choline is an essential nutrient and a critical component of the membrane phospholipid phosphatidylcholine (PC), the neurotransmitter acetylcholine, while also contributing to the methylation pathway.
Conor O’Dwyer, Rebecca Yaworski, Sakie Katsumura, Peyman Ghorbani, Kaelan Gobeil Odai, Julia R.C. Nunes, Nicholas D. LeBlond, Sabrin Sanjana, Tyler T.K. Smith, Shauna Han, Kaitlyn D. Margison, Tommy Alain, Masahiro Morita, Morgan D. Fullerton   +13 more
doaj   +1 more source

Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity. [PDF]

, 2011
The endoplasmic reticulum (ER) is the main site of protein and lipid synthesis, membrane biogenesis, xenobiotic detoxification and cellular calcium storage, and perturbation of ER homeostasis leads to stress and the activation of the unfolded protein ...
AK Cardozo, Alexander R. Ivanov, B Cox, D Ron, E Erbay, G Li, GS Hotamisligil, Gökhan S. Hotamisligil, H Cao, HF Lodish, HL Kammoun, J Schiller, KH Cheng, L Moore, Lee Dicker, Ling Yang, M Kars, MF Gregor, MS Brown, NM Borradaile, Oliver Hofmann, Ping Li, RL Jacobs, S Oyadomari, SJ Kim, Steven M. Watkins, Suneng Fu, SW Park, SY Li, U Ozcan, Winston Hide, Xihong Lin, Y Li, Y Miyauchi   +33 more
core   +2 more sources