Results 71 to 80 of about 8,868 (194)

Relationship Between Dietary Choline Intake and Cognitive Function in the United States: A Cross‐Sectional Study of the 2011–2014 NHANES Cycle

Food Science &Nutrition, Volume 14, Issue 3, March 2026.
In this study, we found a negative relationship between choline intake (dietary choline and total choline) and cognitive function in the elderly population of the United States. RCS analysis showed a U‐shaped association between choline intake and cognitive test (DSST) scores. Interaction analysis suggests that gender and hypertension status may affect
Yu‐hang Chen, Ting‐ting Liu, Li‐ming Chen   +2 more
wiley   +1 more source

RNA‐Binding Proteins and Ferroptosis in Cancer: Mechanism and Therapeutic Implications

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Ferroptosis critically influences cancer cell fate and represents a promising therapeutic strategy. Emerging evidence identifies RNA‐binding proteins (RBPs) as key post‐transcriptional regulators of ferroptosis. The figure summarizes ferroptosis‐related RBPs across cancers: blue RBPs act as tumor suppressors by promoting ferroptosis, whereas red RBPs ...
Linlin Chang, Bin Lu, Haotian Shang, Wanjing Ding, Chunhua Wei, Xiaotian Qi, Pengxing He   +6 more
wiley   +1 more source

One-carbon metabolism, cognitive impairment and CSF measures of Alzheimer pathology: homocysteine and beyond. [PDF]

, 2017
Hyperhomocysteinemia is a risk factor for cognitive decline and dementia, including Alzheimer disease (AD). Homocysteine (Hcy) is a sulfur-containing amino acid and metabolite of the methionine pathway.
Bowman, G.L., Collino, S., Corthésy, J., Da Silva, L., Dayon, L., Descombes, P., Guiraud, S.P., Henry, H., Kussmann, M., Marquis, J., Martin, F.J., Migliavacca, E., Montoliu, I., Moullet, B., Métairon, S., Oikonomidi, A., Popp, J., Tautvydaitė, D., Wojcik, J.   +18 more
core   +2 more sources

Aging‐Derived Alterations in Genomic, Immune, and Metabolic Networks: Implications for Cancer Development and Therapy

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Ageing acts as a double‐edged sword in cancer. In the elderly, open chromatin, immunosenescence, and chronic inflammation drive SASP (IL‐6, MMPs), MDSC accumulation and T‐cell suppression, fostering tumor‐promoting microenvironments and limited therapeutic benefit.
Qi Wang, Xue Sun, Xinhao Han, Xingda Zhang, Wenzheng Wang, Hongbin Wang, He Ren, Lina Gu   +7 more
wiley   +1 more source

Betaine homocysteine S-methyltransferase emerges as a new player of the nuclear methionine cycle [PDF]

, 2017
The paradigm of a cytoplasmic methionine cycle synthesizing/eliminating metabolites that are transported into/out of the nucleus as required has been challenged by detection of significant nuclear levels of several enzymes of this pathway.
Garrido, Francisco, Pajares, María A., Pérez-Miguelsanz, Juliana, Pérez-Sala, Dolores, Reytor, Edel, Vallecillo, Néstor   +5 more
core   +1 more source

The Role of One‐Carbon Metabolism in Cancer and Its Therapeutic Significance

MedComm – Oncology, Volume 5, Issue 1, March 2026.
One‐Carbon metabolism in T‐cell activation and tumor competition. T‐cell activation shifts metabolic pathways, promoting anabolic metabolism and bioenergetic capacity. One‐carbon metabolism plays a crucial role in histone and DNA methylation in activated T cells.
Yuting Jiang, Guoliang Zhou, Qian Zhang, Shengtao Zhou   +3 more
wiley   +1 more source

Combined dietary folate, vitamin B-12, and vitamin B-6 intake influences plasma docosahexaenoic acid concentration in rats

Nutrition & Metabolism, 2012
Background Folate, vitamin B-12, and vitamin B-6 are essential nutritional components in one-carbon metabolism and are required for methylation capacity. The availability of these vitamins may therefore modify methylation of phosphatidylethanolamine (PE)
van Wijk Nick, Watkins Carol J, Hageman Robert J J, Sijben John C W, Kamphuis Patrick G H J, Wurtman Richard J, Broersen Laus M   +6 more
doaj   +1 more source

Functional analysis of lipid metabolism genes in wine yeasts during alcoholic fermentation at low temperature [PDF]

, 2014
11 pages, 1 table, 6 figures.Wine produced by low-temperature fermentation is mostly considered to have improved sensory qualities. However few commercial wine strains available on the market are well-adapted to ferment at low temperature (10 – 15°C ...
Chiva, Rosana, García Ríos, Estéfani, Guillamón, José Manuel, López Malo, María   +3 more
core   +4 more sources

ALDH2 Mediated Ferroptosis Regulation in Ischemia–Reperfusion Injury

Journal of Cellular and Molecular Medicine, Volume 30, Issue 6, March 2026.
ABSTRACT Ischemia–reperfusion injury (IRI) is a common complication in diverse clinical settings, including myocardial infarction, stroke, organ transplantation and major surgery. Its pathological core lies in the metabolic disruption caused by blood flow cessation, followed by oxidative stress, inflammatory cascades and cell death upon reperfusion ...
Liang Han, Wen Zhai
wiley   +1 more source

Estrogen Regulation of the human PEMT (phosphatidylethanolamine N‐methyltransferase) gene

The FASEB Journal, 2006
Choline is an essential nutrient for humans, though some part of this requirement can be met by endogenous synthesis catalyzed by phosphatidylethanolamine N‐methyltransferase (PEMT). Human diets which lack sufficient choline intake can result in organ and muscle dysfunction.
Mary Resseguie, Jiannan Song, Kerry‐Ann da Costa, Shuli Wang, Olga Kozyreva, Steven H. Zeisel   +5 more
openaire   +1 more source