Serum Metabolomics in a Helicobacter hepaticus Mouse Model of Inflammatory Bowel Disease Reveal Important Changes in the Microbiome, Serum Peptides, and Intermediary Metabolism [PDF]
Inflammatory bowel disease (IBD) is a chronic relapsing inflammatory disorder of the bowel. The etiology remains unknown, but IBD is immune-driven and multiple factors including genetic, environmental, and microbiological components play a role ...
Fox, James G. +4 more
core +1 more source
ABSTRACT High‐temperature stress severely threatens rice (Oryza sativa L.) growth and productivity, particularly during the seedling stage, making heat tolerance an essential breeding target. In this study, we identified the heat shock transcription factor OsHsfc1a as a positive regulator of thermotolerance in rice seedlings.
Jingqin Lu +11 more
wiley +1 more source
Objective: To investigate the effects and mechanisms of pomegranate flower water extract on hepatic insulin signaling in type 2 diabetic mice. Methods: C57BL/6J was randomly divided into normal group, model group, metformin group (Met), pomegranate ...
Yumeng YE +4 more
doaj +1 more source
SYNTHESIS AND QUALITY ASSESSMENT OF THE POSITRON EMITTER RADIOTRACER 2-[18F]-FLUOROETHYLCHOLINE, A [18F]-LABELLED CHOLINE ANALOGUE FOR TUMOURS IMAGING [PDF]
Introduction: [18F]-labelled choline analogues, such as 2-[18F]-Fluoroethylcholine ( [18F]-FECH ), have suggested to be the new generation of choline derivatives for the imaging of prostate and brain tumours.
Asti, Mattia
core
The patatin-containing phospholipase A pPLAIIα modulates oxylipin formation and water loss in Arabidopsis thaliana [PDF]
The patatin-related phospholipase A (pPLA) hydrolyzes membrane glycerolipids to produce monoacyl compounds and free fatty acids. Phospholipids are cleaved by pPLAIIα at the sn-1 and sn-2 positions, and galactolipids, including those containing ...
Bahn, Sung Chul +10 more
core +1 more source
The role of lipids in the biogenesis of integral membrane proteins [PDF]
Most integral membrane proteins are cotranslationally inserted into the lipid bilayer. In prokaryotes, membrane insertion of the nascent chain takes place at the plasma membrane, whereas in eukaryotes insertion takes place into the endoplasmatic ...
Schneiter, Roger, Toulmay, Alexandre
core
In Parkinson's disease, SHMT1 downregulation disrupts its interaction with PEMT in astrocytes, reducing SAM levels. This leads to H3K4me1 hypomethylation and decreased Slc1a2/Glul expression, ultimately exacerbating neuroexcitotoxicity and dopaminergic neuron loss.
Yue‐Han Chen +17 more
wiley +1 more source
Identification and characterization of pptA: a gene involved in the phase-variable expression of phosphorylcholine on pili of Neisseria meningitidis [PDF]
Pili of pathogenic Neisseria are major virulence factors associated with adhesion, cytotoxicity, twitching motility, autoaggregation, and DNA transformation. Pili are modified posttranslationally by the addition of phosphorylcholine.
Warren, Matthew J., Jennings, Michael P.
core +1 more source
ABSTRACT Background Lung cancer remains the leading cause of cancer‐related mortality worldwide, highlighting the urgent need for earlier detection within real‐world screening and patient management pathways. Recent advances in multi‐omics technologies have created new opportunities for identifying biomarkers associated with early‐stage lung cancer ...
Fan Bu, Zhi‐Qiang Ling
wiley +1 more source
Transcriptome profiling of the rice blast fungus during invasive plant infection and in vitro stresses [PDF]
Background Rice blast is the most threatening disease to cultivated rice. Magnaporthe oryzae, its causal agent, is likely to encounter environmental challenges during invasive growth in its host plants that require shifts in gene expression to establish ...
Sandra M Mathioni +4 more
core +1 more source

