Results 1 to 10 of about 362,977 (248)

Lithium amplifies agonist-dependent phosphatidylinositol responses in brain and salivary glands. [PDF]

Biochemical Journal, 1982
1. The effect of Li+ on the agonist-dependent metabolism of [3H]inositol has been studied in rat brain, rat parotid and the insect salivary gland. 2. When brain or parotid slices were incubated in the presence of [3H]inositol, Li+ was found to amplify ...
M. Berridge, C. Downes, M. Hanley
semanticscholar   +2 more sources

Drosophila Lipase 3 Mediates the Metabolic Response to Starvation and Aging

Frontiers in Aging, 2022
The human LIPA gene encodes for the enzyme lysosomal acid lipase, which hydrolyzes cholesteryl ester and triacylglycerol. Lysosomal acid lipase deficiency results in Wolman disease and cholesteryl ester storage disease.
Lea Hänschke, Christoph Heier, Christoph Heier, Christoph Heier, Santiago José Maya Palacios, Huseyin Erdem Özek, Christoph Thiele, Reinhard Bauer, Ronald P. Kühnlein, Ronald P. Kühnlein, Ronald P. Kühnlein, Margret H. Bülow   +11 more
doaj   +1 more source

Lipid droplets formation and their effects on phosphatidylinositol level in yeasts [PDF]

Novel Research in Microbiology Journal, 2020
Lipid droplets (LDs) are conserved specialized organelles that are surrounded by a single phospholipid layer, enclosing neutral lipids in form of triacylglycerol (TAG) and/or sterol ester.
Fabrice Mutijima, Mostafa Basiony, Morihisa Fujita   +2 more
doaj   +1 more source

Blocking K-Ras Interaction With the Plasma Membrane Is a Tractable Therapeutic Approach to Inhibit Oncogenic K-Ras Activity

Frontiers in Molecular Biosciences, 2021
Ras proteins are membrane-bound small GTPases that promote cell proliferation, differentiation, and apoptosis. Consistent with this key regulatory role, activating mutations of Ras are present in ∼19% of new cancer cases in the United States per year.
Karen M. Henkels, Kristen M. Rehl, Kwang-jin Cho   +2 more
doaj   +1 more source

Phosphatidylcholine Cation—Tyrosine π Complexes: Motifs for Membrane Binding by a Bacterial Phospholipase C

Molecules, 2022
Phosphatidylinositol-specific phospholipase C (PI-PLC) enzymes are a virulence factor in many Gram-positive organisms. The specific activity of the Bacillus thuringiensis PI-PLC is significantly increased by adding phosphatidylcholine (PC) to vesicles ...
Mary F. Roberts, Anne Gershenson, Nathalie Reuter   +2 more
doaj   +1 more source

Role of SEC14-like phosphatidylinositol transfer proteins in membrane identity and dynamics

Frontiers in Plant Science, 2023
Membrane identity and dynamic processes, that act at membrane sites, provide important cues for regulating transport, signal transduction and communication across membranes.
Karolin Montag, Rumen Ivanov, Petra Bauer, Petra Bauer   +3 more
doaj   +1 more source

Early Serum Metabolism Profile of Post-operative Delirium in Elderly Patients Following Cardiac Surgery With Cardiopulmonary Bypass

Frontiers in Aging Neuroscience, 2022
BackgroundCardiac surgery with cardiopulmonary bypass (CPB) is considered to be one of the surgical types with the highest incidence of post-operative delirium (POD).
He Huang, Jingjing Han, Yan Li, Yonglin Yang, Jian Shen, Qiang Fu, Yu Chen   +6 more
doaj   +1 more source

Identification and Characterization of a Novel Basic Helix-Loop-Helix Transcription Factor of Phospholipid Synthesis Regulation in Aspergillus niger

Frontiers in Microbiology, 2020
The synthesis of phospholipids relies on a sort of genes, whose promoter regions contain inositol-sensitive upstream activation sequence (UASINO) and are regulated by the basic helix-loop-helix (bHLH)-type ino2/ino4 transcription factor (TF) pair.
Hongzhi Dong, Hongzhi Dong, Dou Yu, Dou Yu, Bin Wang, Bin Wang, Li Pan, Li Pan   +7 more
doaj   +1 more source

The Genetic Background of Abnormalities in Metabolic Pathways of Phosphoinositides and Their Linkage with the Myotubular Myopathies, Neurodegenerative Disorders, and Carcinogenesis

Biomolecules, 2023
Myo-inositol belongs to one of the sugar alcohol groups known as cyclitols. Phosphatidylinositols are one of the derivatives of Myo-inositol, and constitute important mediators in many intracellular processes such as cell growth, cell differentiation ...
Maria Derkaczew, Piotr Martyniuk, Robert Hofman, Krzysztof Rutkowski, Adam Osowski, Joanna Wojtkiewicz   +5 more
doaj   +1 more source

Phosphatidylinositol (4,5)-bisphosphate turnover by INP51 regulates the cell wall integrity pathway in "Saccharomyces cerevisiae" [PDF]

, 2004
Signal transduction pathways are important for the cell to transduce external or internal stimuli where second messengers play an important role as mediators of the stimuli. One important group of second messengers are the phosphoinositide family present
Morales-Johansson, Helena
core   +2 more sources