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The Genetic Background of Abnormalities in Metabolic Pathways of Phosphoinositides and Their Linkage with the Myotubular Myopathies, Neurodegenerative Disorders, and Carcinogenesis

Biomolecules, 2023
Myo-inositol belongs to one of the sugar alcohol groups known as cyclitols. Phosphatidylinositols are one of the derivatives of Myo-inositol, and constitute important mediators in many intracellular processes such as cell growth, cell differentiation ...
Maria Derkaczew, Piotr Martyniuk, Robert Hofman, Krzysztof Rutkowski, Adam Osowski, Joanna Wojtkiewicz   +5 more
doaj   +1 more source

Early Serum Metabolism Profile of Post-operative Delirium in Elderly Patients Following Cardiac Surgery With Cardiopulmonary Bypass

Frontiers in Aging Neuroscience, 2022
BackgroundCardiac surgery with cardiopulmonary bypass (CPB) is considered to be one of the surgical types with the highest incidence of post-operative delirium (POD).
He Huang, Jingjing Han, Yan Li, Yonglin Yang, Jian Shen, Qiang Fu, Yu Chen   +6 more
doaj   +1 more source

SAC1 regulates autophagosomal phosphatidylinositol-4-phosphate for xenophagy-directed bacterial clearance

Cell Reports, 2021
Summary: Phosphoinositides are important molecules in lipid signaling, membrane identity, and trafficking that are spatiotemporally controlled by factors from both mammalian cells and intracellular pathogens.
Kai Liu, Lingjia Kong, Daniel B. Graham, Kimberly L. Carey, Ramnik J. Xavier   +4 more
doaj   +1 more source

Physical Properties and Reactivity of Microdomains in Phosphatidylinositol-Containing Supported Lipid Bilayer

Membranes, 2021
We characterized the size, distribution, and fluidity of microdomains in a lipid bilayer containing phosphatidylinositol (PI) and revealed their roles during the two-dimensional assembly of a membrane deformation protein (FBP17).
Toshinori Motegi, Kingo Takiguchi, Yohko Tanaka-Takiguchi, Toshiki Itoh, Ryugo Tero   +4 more
doaj   +1 more source

Role of SEC14-like phosphatidylinositol transfer proteins in membrane identity and dynamics

Frontiers in Plant Science, 2023
Membrane identity and dynamic processes, that act at membrane sites, provide important cues for regulating transport, signal transduction and communication across membranes.
Karolin Montag, Rumen Ivanov, Petra Bauer, Petra Bauer   +3 more
doaj   +1 more source

Genetic Analysis and Molecular Mapping of the Quantitative Trait Loci Governing Low Phytic Acid Content in a Novel LPA Rice Mutant, PLM11

Plants, 2020
Breeding rice varieties with a low phytic acid (LPA) content is an effective strategy to overcome micronutrient deficiency in a population which consume rice as a staple food.
Prem Chand Gyani, Haritha Bollinedi, Subbaiyan Gopala Krishnan, Kunnummal Kurungara Vinod, Archana Sachdeva, Prolay Kumar Bhowmick, Ranjith Kumar Ellur, Mariappan Nagarajan, Ashok Kumar Singh   +8 more
doaj   +1 more source

Lipid droplets formation and their effects on phosphatidylinositol level in yeasts [PDF]

Novel Research in Microbiology Journal, 2020
Lipid droplets (LDs) are conserved specialized organelles that are surrounded by a single phospholipid layer, enclosing neutral lipids in form of triacylglycerol (TAG) and/or sterol ester.
Fabrice Mutijima, Mostafa Basiony, Morihisa Fujita   +2 more
doaj   +1 more source

Phosphatidylinositol Stabilizes Fluid-Phase Liposomes Loaded with a Melphalan Lipophilic Prodrug

Pharmaceutics, 2021
Previously, a liposomal formulation of a chemotherapeutic agent melphalan (Mlph) incorporated in a fluid lipid bilayer of natural phospholipids in the form of dioleoylglyceride ester (MlphDG) was developed and the antitumor effect was confirmed in mouse ...
Daria Tretiakova, Irina Le-Deigen, Natalia Onishchenko, Judith Kuntsche, Elena Kudryashova, Elena Vodovozova   +5 more
doaj   +1 more source

Phosphatidylcholine Cation—Tyrosine π Complexes: Motifs for Membrane Binding by a Bacterial Phospholipase C

Molecules, 2022
Phosphatidylinositol-specific phospholipase C (PI-PLC) enzymes are a virulence factor in many Gram-positive organisms. The specific activity of the Bacillus thuringiensis PI-PLC is significantly increased by adding phosphatidylcholine (PC) to vesicles ...
Mary F. Roberts, Anne Gershenson, Nathalie Reuter   +2 more
doaj   +1 more source

Blocking K-Ras Interaction With the Plasma Membrane Is a Tractable Therapeutic Approach to Inhibit Oncogenic K-Ras Activity

Frontiers in Molecular Biosciences, 2021
Ras proteins are membrane-bound small GTPases that promote cell proliferation, differentiation, and apoptosis. Consistent with this key regulatory role, activating mutations of Ras are present in ∼19% of new cancer cases in the United States per year.
Karen M. Henkels, Kristen M. Rehl, Kwang-jin Cho   +2 more
doaj   +1 more source