Results 131 to 140 of about 363,126 (392)

CDP-diacylglycerol synthases regulate the growth of lipid droplets and adipocyte development[S]

Journal of Lipid Research, 2016
The expansion of lipid droplets (LDs) and the differentiation of preadipocytes are two important aspects of mammalian lipid storage. In this study, we examined the role of CDP-diacylglycerol (DAG) synthases (CDSs), encoded by CDS1 and CDS2 genes in ...
Yanfei Qi, Tamar S. Kapterian, Ximing Du, Qianli Ma, Weihua Fei, Yuxi Zhang, Xun Huang, Ian W. Dawes, Hongyuan Yang   +8 more
doaj  

The degree and position of phosphorylation determine the impact of toxic and trace metals on phosphoinositide containing model membranes

BBA Advances, 2021
This work assessed effects of metal binding on membrane fluidity, liposome size, and lateral organization in biomimetic membranes composed of 1 mol% of selected phosphorylated phosphoinositides in each system.
Weiam Daear, Robyn Mundle, Kevin Sule, Elmar J Prenner   +3 more
doaj  

Animal cell cytokinesis: the role of dynamic changes in the plasma membrane proteome and lipidome [PDF]

, 2016
In animal cells, cytokinesis is characterised by the formation of the mitotic spindle that signals the assembly of an actomyosin ring between the spindle poles.
Gould, Gwyn W.
core   +2 more sources

Presbycusis: Pathology, Signal Pathways, and Therapeutic Strategy

Advanced Science, EarlyView.
In ARHL, the stria vascularis, acting as a cochlear battery, gradually loses its ability to maintain the endocochlear potential, leading to impaired hair cell function and progressive hearing loss. Single‐cell sequencing reveals age‐related cellular changes in the cochlea, providing insights into the underlying mechanisms of aging and potential ...
Xiaoxu Zhao, Tian Shen, Shengda Cao, Ziyi Liu, Wendu Pang, Meixuan Li, Jingjing Liu, Wen Li, Yunhao Wu, Chengcheng Liu, Ming Xia, Xiaolong Fu, Cheng Cheng   +12 more
wiley   +1 more source

Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses.

Biochemical Journal, 1993
Phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) is rapidly produced upon exposure of neutrophils to the chemoattractant N-formylmethionyl-leucylphenylalanine (fMLP), and has been proposed to act as a second messenger mediating actin polymerization ...
A. Arcaro, M. Wymann
semanticscholar   +1 more source

Characterization of phosphatidylinositol, phosphatidylinositol-4-phosphate, and phosphatidylinositol-4,5-bisphosphate by electrospray ionization tandem mass spectrometry: A mechanistic study

Journal of the American Society for Mass Spectrometry, 2000
Structural characterization of phosphatidylinositol (PI), phosphatidylinositol-4-phosphate (PI-4P), and phosphatidylinositol-4,5-bisphosphate (PI-4,5-P2) by collisionally activated dissociation (CAD) tandem mass spectrometry with electrospray ionization is described.
Fong-Fu Hsu, John Turk
openaire   +3 more sources

Tau Pathology Drives Disease‐Associated Astrocyte Reactivity in Salt‐Induced Neurodegeneration

Advanced Science, Volume 12, Issue 11, March 20, 2025.
This study reveals that a high‐salt diet (HSD) induces enhanced reactivity of DAA‐like astrocytes in the hippocampal CA3 region via a tau pathology‐A1R signaling axis, forming a vicious cycle that perpetuates astrocyte reactivity. Neuronal tau pathology releases PAPDs, notably Lcn2, driving neuroinflammation.
Tong‐Yu Rui, He‐Zhou Huang, Kai Zheng, Hong‐Wei Fan, Juan Zhang, Zi‐Yuan Guo, Heng‐Ye Man, Nadezhda Brazhe, Alexey Semyanov, You‐Ming Lu, Dan Liu, Ling‐Qiang Zhu   +11 more
wiley   +1 more source

Two Distinct Vps34 Phosphatidylinositol 3–Kinase Complexes Function in Autophagy and Carboxypeptidase Y Sorting inSaccharomyces cerevisiae

Journal of Cell Biology, 2001
Vps30p/Apg6p is required for both autophagy and sorting of carboxypeptidase Y (CPY). Although Vps30p is known to interact with Apg14p, its precise role remains unclear. We found that two proteins copurify with Vps30p.
A. Kihara, Takeshi Noda, Naotada Ishihara, Y. Ohsumi   +3 more
semanticscholar   +1 more source

The phosphatidylinositol kinase of rat brain [PDF]

, 1966
Masahiro Kai, G. L. White, JN Hawthorne
openalex   +1 more source

Advances in Electrical Materials for Bone and Cartilage Regeneration: Developments, Challenges, and Perspectives

Advanced Science, EarlyView.
This review explores the challenges of treating bone and cartilage defects, emphasizing the role of endogenous electric fields in bone and cartilage regeneration. It highlights recent advancements in electroactive biomaterials, including nanogenerators, piezoelectric materials, triboelectric scaffold, and zwitterionic hydrogels.
Yubin Yao, Xi Cui, Shenglong Ding, Ketao Wang, Mingzhu Zhang   +4 more
wiley   +1 more source