Results 211 to 220 of about 387,101 (335)

TULP4, a novel E3 ligase gene, participates in neuronal migration as a candidate in schizophrenia

CNS Neuroscience &Therapeutics, EarlyView., 2023
Mutations identified from four SCZ pedigrees resulted in decreased TULP4 expression. Tulp4 knockdown caused delayed neuron migration in embryonic mice, and impaired cognition and prepulse inhibition in adult mice. These phenotypes may be related to TULP4 through its involvement in the formation of a novel E3 ubiquitin ligases.
Yan Bi, Decheng Ren, Fan Yuan, Zhou Zhang, Daizhan Zhou, Xin Yi, Lei Ji, Keyi Li, Fengping Yang, Xi Wu, Xingwang Li, Yifeng Xu, Yun Liu, Peng Wang, Changqun Cai, Chuanxin Liu, Qian Ma, Lin He, Yi Shi, Guang He   +19 more
wiley   +1 more source

EP4 influences bortezomib resistance in multiple myeloma by modulating endoplasmic reticulum stress via the phosphatidylinositol 3-kinase/protein kinase B pathway. [PDF]

Anticancer Drugs
Shi T, Chen Y, Liu Z, Liu A.
europepmc   +1 more source

PTEN, but Not SHIP2, Suppresses Insulin Signaling through the Phosphatidylinositol 3-Kinase/Akt Pathway in 3T3-L1 Adipocytes [PDF]

, 2005
Xiaoqing Tang, Aimee M. Powelka, Neil A. Soriano, Michael Czech, Adı́lson Guilherme   +4 more
openalex   +1 more source

Placenta‐derived extracellular vesicles: Signal messengers shuttling across the maternal‐fetal barrier

Interdisciplinary Medicine, EarlyView.
In normal pregnancy, PEVs help maintain maternal–fetal immune tolerance while enabling controlled immune activation, promote endothelial migration, and support trophoblast invasion and syncytialization, strengthening antimicrobial defense. In pregnancy‐related disorders, dysregulated PEV signaling may drive endothelial dysfunction and hypertension, BBB
Jiale Du, Maliang Tao, Yanxuan Xiao, Zhijian Wang, Bo Situ, Lei Zheng   +5 more
wiley   +1 more source

The Whole Transcriptome Sequencing Profile of Serum-Derived Exosomes and Potential Pathophysiology of Age-Related Hearing Loss. [PDF]

Diagnostics (Basel)
Yang G, Xie Z, Huang Y, Ke J, Tang Z, Chen Z, Kuang S, Li F, Luo H, Lai Q, Wang B, Zhang J, Yuan W.   +12 more
europepmc   +1 more source

UBE3A Inhibits Trophoblast Cell Migration and Invasion by Promoting ITGB1 Degradation and Affecting PI3K/AKT Signaling

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Preeclampsia (PE) is an obstetric disease that is characterized by reduced migration and invasion of placental trophoblast cells. Here, the effects of the E3 ubiquitin ligase UBE3A on the migration and invasion of trophoblast cells were evaluated.
Xiu‐Jun Li, Ning Wang, Fan Jiang, Jie‐Cheng Yang, Yan‐Yun Wang, Kun Wang   +5 more
wiley   +1 more source

Distinct impact of PI(4)P flux on PI(4,5)P₂ steady states and oscillations. [PDF]

Proc Natl Acad Sci U S A
Xǔ XJ, Tong CS, Wu M.
europepmc   +1 more source

Epidermal Growth Factor-induced Phosphatidylinositol 3-Kinase Activation and DNA Synthesis [PDF]

, 2000
Mei Kong, Cathérine Mounier, Jiong Wu, Barry I. Posner   +3 more
openalex   +1 more source

Melatonin Exerts Chondroprotective Effects Against Osteoarthritis by Promoting PI3K/AKT/FoxO3‐Mediated Mitophagy

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Osteoarthritis (OA) is a prevalent degenerative joint disease. This study combines bioinformatics analysis with in vivo and in vitro experiments to elucidate the molecular mechanisms through which melatonin (MT) regulates mitophagy to alleviate OA.
Chao Huang, Gang Zhang, Ying‐Kai Ma, Xin‐Nan Ma, Song‐Cen Lv   +4 more
wiley   +1 more source

Systematic analyses of lipid mobilization by human lipid transfer proteins. [PDF]

Nature
Titeca K, Chiapparino A, Hennrich ML, Türei D, Moqadam M, Talandashti R, Cuveillier C, van Ek L, Zukowska J, Triana S, Echelard F, Nielsen IØ, Foged MM, Gehin C, Olechnovic K, Grudinin S, Saez-Rodriguez J, Alexandrov T, Maeda K, Reuter N, Gavin AC.   +20 more
europepmc   +1 more source