Do anionic phospholipids serve as cofactors or second messengers for the regulation of activity of cloned ATP-sensitive K+ channels? [PDF]
, 2003 The regulation of ion channels by anionic phospholipids is currently very topical. An outstanding issue is whether phosphatidylinositol 4,5-diphosphate and related species act as true second messengers in signaling or behave in a manner analogous to an ...
Clapp, LH +4 more
core +1 more source
Journal of Lipid Research, 2009 Glycerophospholipids are structural and functional components of cellular membranes as well as precursors of various lipid mediators. Using acyl-CoAs as donors, glycerophospholipids are formed by the de novo pathway (Kennedy pathway) and modified in the ...
Koichi Yuki +3 more
doaj +1 more source
Mutational analysis of human profilin I reveals a second PI(4,5)-P2 binding site neighbouring the poly(L-proline) binding site [PDF]
, 2002 Background: Profilin is a small cytoskeletal protein which interacts with actin, proline-rich proteins and phosphatidylinositol 4,5-bisphosphate (PI(4,5)-P-2).
Ampe, Christophe +4 more
core +3 more sources
Relationship between membrane phosphatidylinositol-4,5-bisphosphate and receptor-mediated inhibition of native neuronal M channels [PDF]
, 2005 The relationship between receptor-induced membrane phosphatidylinositol-4'5'-bisphosphate (PIP2) hydrolysis and M-current inhibition was assessed in single-dissociated rat sympathetic neurons by simultaneous or parallel recording of membrane current and ...
Abogadie, FC +6 more
core +1 more source
Serum phospholipids during aging: A comprehensive systematic review of cross-sectional and case-control studies [PDF]
Health Promotion PerspectivesBackground: The lipidome, as a subset of metabolomics, can undergo significant variations due to several factors, including the aging process. Therefore, this study aims to summarize the relationship between aging and alterations in plasma phospholipids.
Meysam Zarezadeh +7 more
doaj +1 more source
Journal of Lipid Research, 2022 Previous work from us and others has suggested that cholesterol is an important lipid in the context of the organization of the actin cytoskeleton.
Parijat Sarkar +3 more
doaj +1 more source
Journal of Lipid Research, 1971 Rat and guinea pig liver microsomes labeled with phospholipid 32P were incubated with rat, guinea pig, and rabbit plasma in a KC1–Tris–EDTA buffer. A net transfer of microsomal phosphatidylcholine and phosphatidylethanolamine to plasma was observed.
D.B. ZILVERSMIT
doaj +1 more source
Plasma Membrane Phosphatidylinositol 4-Phosphate Is Necessary for Virulence of Candida albicans
mBio, 2022 Phosphatidylinositol lipids regulate key processes, including vesicle trafficking and cell polarity. A recent study identified novel roles for phosphatidylinositol 4-phosphate (PI4P) in the plasma membrane of the fungal pathogen Candida albicans ...
James B. Konopka
doaj +1 more source
Editorial: Membrane lipids in T cell functions [PDF]
, 2018 Plasma membrane lipids play essential roles in regulating T cell signaling, differentiation, and effector functions. The major lipid species in the plasma membrane are glycerophospholipids, sphingolipids, and sterol lipids.
Tuosto, Loretta, Xu, Chenqi
core +1 more source
Hepatic deletion of Mboat7 (LPIAT1) causes activation of SREBP-1c and fatty liver
Journal of Lipid Research, 2021 : Genetic variants that increase the risk of fatty liver disease and cirrhosis have recently been identified in the proximity of membrane-bound O-acyltransferase domain-containing 7 (MBOAT7).
Mingfeng Xia +4 more
doaj +1 more source