Results 51 to 60 of about 387,101 (335)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

In vitro mimicry of essential fatty acid deficiency in human endothelial cells by TNFα impact of ω-3 versus ω-6 fatty acids

Journal of Lipid Research, 2002
Severe endothelial abnormalities are a prominent feature in sepsis with cytokines such as tumor necrosis factor (TNF)α being implicated in the pathogenesis.
Konstantin Mayer, Reinhold Schmidt, Marion Muhly-Reinholz, Tina Bögeholz, Stephanie Gokorsch, Friedrich Grimminger, Werner Seeger   +6 more
doaj   +1 more source

The degree and position of phosphorylation determine the impact of toxic and trace metals on phosphoinositide containing model membranes

BBA Advances, 2021
This work assessed effects of metal binding on membrane fluidity, liposome size, and lateral organization in biomimetic membranes composed of 1 mol% of selected phosphorylated phosphoinositides in each system.
Weiam Daear, Robyn Mundle, Kevin Sule, Elmar J Prenner   +3 more
doaj   +1 more source

An amphitropic cAMP-binding protein in yeast mitochondria [PDF]

, 1989
: We describe the first example of a mitochondrial protein with a covalently attached phos-phatidylinositol moiety acting as a membrane anchor. The protein can be metabolically labeled with both stearic acid and inositol.
Bandlow W., Baranska J., Blok M., Brugge J., Burn P., Burn P., Cascales S. C., Cobon G. S., Cobon G. S., Cornell R., Courtneidge S. A., Cross G. A. M., Dils R. R., Dygas A., Gillfillan A. M., Guarnieri M., Hixson C. S., Hostetler K. Y., Jelsema C. L., Kraft A. S., Lassing I., Lassing I., Low M. G., Megli F. M., Meyer R. K., Muller G., Muller G., Muller G., Muller G., Nishizuka Y., Pelech S. L., Radika R., Rodel G., Rotman A., Schmidt M. F. G., Sefton B. M., Sleight R., Terce F., Towbin H., Wirtz K. W. A., Wirtz K. W. A., Wojtczak L., Yaffe M., Zborowski J.   +43 more
core   +3 more sources

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases. [PDF]

, 2008
The clinical success of multitargeted kinase inhibitors has stimulated efforts to identify promiscuous drugs with optimal selectivity profiles. It remains unclear to what extent such drugs can be rationally designed, particularly for combinations of ...
Aizenstein, Brian, Apsel, Beth, Blair, Jimmy A, Feldman, Morri E, Gonzalez, Beatriz, Hoffman, Randy, Knight, Zachary A, Nazif, Tamim M, Shokat, Kevan M, Williams, Roger L   +9 more
core  

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

CDP-diacylglycerol synthases regulate the growth of lipid droplets and adipocyte development[S]

Journal of Lipid Research, 2016
The expansion of lipid droplets (LDs) and the differentiation of preadipocytes are two important aspects of mammalian lipid storage. In this study, we examined the role of CDP-diacylglycerol (DAG) synthases (CDSs), encoded by CDS1 and CDS2 genes in ...
Yanfei Qi, Tamar S. Kapterian, Ximing Du, Qianli Ma, Weihua Fei, Yuxi Zhang, Xun Huang, Ian W. Dawes, Hongyuan Yang   +8 more
doaj   +1 more source

Phosphoinositide Profile of the Mouse Retina

Cells, 2020
Phosphoinositides are known to play multiple roles in eukaryotic cells. Although dysregulation of phosphoinositide metabolism in the retina has been reported to cause visual dysfunction in animal models and human patients, our understanding of the ...
Stella Finkelstein, Sidney M. Gospe, Kai Schuhmann, Andrej Shevchenko, Vadim Y. Arshavsky, Ekaterina S. Lobanova   +5 more
doaj   +1 more source