Results 51 to 60 of about 363,126 (392)

A Role for Phosphoinositides in Regulating Plant Nuclear Functions

Frontiers in Plant Science, 2012
Nuclear localized inositol phospholipids and inositol phosphates are important for regulating many essential processes in animal cells such as DNA replication, recombination, RNA processing, mRNA export and cell cycle progression.
Catherine B Dieck, Wendy F Boss, Imara Yasmin Perera   +2 more
doaj   +1 more source

Rab27a controls HIV-1 assembly by regulating plasma membrane levels of phosphatidylinositol 4,5-bisphosphate [PDF]

, 2015
During the late stages of the HIV-1 replication cycle, the viral polyprotein Pr55Gag is recruited to the plasma membrane (PM), where it binds phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) and directs HIV-1 assembly.
Balasubramaniam, Balla, Benaroch, Bennett, Berditchevski, Blott, Booth, Buchacher, Bussolino, Carolina Jancic, Carr, Catalina von Bilderling, Catarina Ferreira Moita, Checkley, Chen, Chesebro, Chu, Claudia Banchio, Cox, Deneka, Desnos, Dimitrov, Dong, Doughman, Eric O. Freed, Gabriel Duette, Genevieve de Saint Basile, Gould, Grigorov, Guo, Hammond, Hogue, Hume, Imai, Jolly, Jolly, Jorge Geffner, Joshi, Jouve, Jović, Kang, Kerviel, Krementsov, Krementsov, Li, Lloyd, Lorena Sigaut, Luciana Paoletti, Luis Ferreira Moita, Lía I. Pietrasanta, Manders, Matías Ostrowski, Mercedes Cabrini, Micucci, Minogue, Mlcochova, Moffat, Monde, Ménasché, Ménasché, Nakatsu, Naldini, Ono, Ostrowski, Pan, Pehuén Pereyra Gerber, Philippe Benaroch, Pizarro-Cerdá, Popovic, Raposo, Raposo, Ruiz-Mateos, Salazar, Satoh, Schindler, Sebastian Amigorena, Sibarita, Sundquist, Théry, Trkola, Tsuboi, Tsuboi, Vickers, Villalta, Várnai, Wang, Wei, Welsch, Yauch   +88 more
core   +1 more source

First-in-human phase I study of copanlisib (BAY 80-6946), an intravenous pan-class I phosphatidylinositol 3-kinase inhibitor, in patients with advanced solid tumors and non-Hodgkin's lymphomas

Annals of Oncology, 2016
This phase I study evaluated the safety, tolerability, and pharmacokinetics of copanlisib, an intravenously administered pan-phosphatidylinositol 3-kinase inhibitor in patients with advanced solid tumors or non-Hodgkin's lymphoma.
A. Patnaik, L. Appleman, A. Tolcher, K. Papadopoulos, M. Beeram, D. Rasco, G. Weiss, J. Sachdev, M. Chadha, Monica Fulk, S. Ejadi, J. Mountz, M. Lotze, F. Toledo, E. Chu, M. Jeffers, C. Peña, C. Xia, S. Reif, I. Genvresse, R. Ramanathan   +20 more
semanticscholar   +1 more source

Targeting phosphoinositide 3-kinase (PI3K) in head and neck squamous cell carcinoma (HNSCC). [PDF]

, 2018
The landscape of head and neck squamous cell carcinoma (HNSCC) has been changing rapidly due to growing proportion of HPV-related disease and development of new therapeutic agents.
Jung, Kyungsuk, Kang, Hyunseok, Mehra, Ranee   +2 more
core   +2 more sources

Phosphatidylinositol-linked glycans and phosphatidylinositol-anchored proteins of Tetrahymena mimbres

Journal of Biological Chemistry, 1991
The insoluble residue from Tetrahymena mimbres cells that had been preincubated in vivo for 2 h with [3H]myristic acid and then exhaustively delipidated with organic solvents retained radioactivity, principally in material which migrated on sodium dodecyl sulfate-polyacrylamide gel electrophoresis with an apparent molecular mass of 10-14 kDa.
Guy A. Thompson, Y Pak, P E Ryals
openaire   +3 more sources

Molecular insights into the modulation of the 5HT2A receptor by serotonin, psilocin, and the G protein subunit Gqα

FEBS Letters, Volume 599, Issue 6, Page 876-891, March 2025.
We explore 5HT2A receptor activation, a key target for psychedelic drugs, using molecular dynamics simulations. Without Gqα, the active receptor collapses to an inactive conformation, underscoring the G‐protein's role. Discovery of an intermediate “partially‐open” state and the higher affinity of ligands to the orthosteric binding site provides ...
Niklas Viohl, Ali Asghar Hakami Zanjani, Himanshu Khandelia   +2 more
wiley   +1 more source

Membrane contact sites - an interesting species, an interesting mix [PDF]

, 2013
In this issue of EMBO reports, Loewen and colleagues reveal a role for plasma membrane–endoplasmic reticulum contact sites in regulating phosphatidylcholine synthesis in budding ...
Miller, Vicky J, Stephens, David J
core   +1 more source

Distinct dysregulated pathways in sporadic and Lynch syndrome‐associated colorectal cancer offer insights for targeted treatment

FEBS Letters, Volume 599, Issue 7, Page 1006-1028, April 2025.
This study explores the distinct molecular mechanisms underlying Lynch syndrome‐associated and sporadic colorectal cancer (CRC). By highlighting the therapeutic potential of targeting the PI3K‐Akt pathway in Lynch syndrome‐associated CRC and the Wnt pathway in sporadic CRC, the findings open avenues for personalised treatment strategies, aiming to ...
May J. Krause, Musalula Sinkala, Raj Ramesar   +2 more
wiley   +1 more source

Immunoregulatory mechanisms of the arachidonic acid pathway in cancer

FEBS Letters, Volume 599, Issue 7, Page 927-951, April 2025.
The central role of the arachidonic acid (AA) pathway in anticancer immunity. Enzymes and metabolites of the AA pathway can play both immunosuppressive and immunostimulatory roles in the tumor microenvironment. Therefore, their tailored targeting could be beneficial as a standalone therapy or in combination with current cancer immunotherapy.
Maria Tredicine, Matteo Mucci, Antonio Recchiuti, Domenico Mattoscio   +3 more
wiley   +1 more source

Phosphoinositide Profile of the Mouse Retina

Cells, 2020
Phosphoinositides are known to play multiple roles in eukaryotic cells. Although dysregulation of phosphoinositide metabolism in the retina has been reported to cause visual dysfunction in animal models and human patients, our understanding of the ...
Stella Finkelstein, Sidney M. Gospe, Kai Schuhmann, Andrej Shevchenko, Vadim Y. Arshavsky, Ekaterina S. Lobanova   +5 more
doaj   +1 more source