Results 31 to 40 of about 405,250 (376)
Phosphatidylinositol 3-Kinase Regulates Thymic Exit [PDF]
The Journal of Immunology, 2005 Abstract To understand the role of PI3K during T cell development, we generated transgenic mice expressing the N terminus of the PI3K catalytic subunit (p110ABD; ABD, adaptor binding domain) in thymocytes. Expression of p110ABD activates endogenous p110 and results in the accumulation of mature single-positive CD3highheat-stable Aglow ...
Susannah D, Barbee, Jose, Alberola-Ila
openaire +2 more sources
Journal of Cell Biology, 1998 We have examined the roles of the p85/ p110α and hVPS34 phosphatidylinositol (PI) 3′-kinases in cellular signaling using inhibitory isoform-specific antibodies.
Uma Siddhanta +4 more
semanticscholar +1 more source
The Serine/Threonine Protein Kinase (Akt)/ Protein Kinase B (PkB) Signaling Pathway in Breast Cancer [PDF]
, 2020 According to statistical data published in 2019, breast cancer is among the leading causes of death in women worldwide. The serine/threonine kinase (AKT) or protein kinase B (PkB) signaling pathway is activated by phosphorylation processes, which further
Bratu, Ovidiu Gabriel +8 more
core +3 more sources
The spatial distribution of GPCR and Gβγ activity across a cell dictates PIP3 dynamics
Scientific Reports, 2023 Phosphatidylinositol (3,4,5) trisphosphate (PIP3) is a plasma membrane-bound signaling phospholipid involved in many cellular signaling pathways that control crucial cellular processes and behaviors, including cytoskeleton remodeling, metabolism ...
Dhanushan Wijayaratna +5 more
doaj +1 more source
Journal of Biological Chemistry, 2003 Neisseria gonorrhoeae can be internalized by mammalian cells through interactions between bacterial opacity-associated (Opa) adhesins and members of the humancarcinoembryonic antigen-relatedcellular adhesion molecule (CEACAM) family. We examined the role
J. W. Booth +6 more
semanticscholar +1 more source
Editorial: Membrane lipids in T cell functions [PDF]
, 2018 Plasma membrane lipids play essential roles in regulating T cell signaling, differentiation, and effector functions. The major lipid species in the plasma membrane are glycerophospholipids, sphingolipids, and sterol lipids.
Tuosto, Loretta, Xu, Chenqi
core +1 more source
Phosphatidylinositol 3-Kinase [PDF]
Circulation Research, 2002 The pathogenesis of essential hypertension is multifactorial. Although the cause of elevated arterial pressure is unknown in most cases, the fundamental hemodynamic abnormality in hypertension is increased peripheral resistance primarily due to changes in vascular structure and function.1 These changes include arterial wall thickening and abnormal ...
Masataka, Sata, Ryozo, Nagai
openaire +2 more sources
Beyond antioxidants: the cellular and molecular interactions of flavonoids and how these underpin their actions on the brain [PDF]
, 2010 The consumption of flavonoid-rich foods and beverages has been suggested to limit the neurodegeneration associated with a variety of neurological disorders and to prevent or reverse normal or abnormal deteriorations in cognitive performance.
Spencer, Jeremy Paul
core +1 more source
Phosphatidylinositol 3-Kinase: The Oncoprotein [PDF]
, 2010 The catalytic and regulatory subunits of class I phosphoinositide 3-kinase (PI3K) have oncogenic potential. The catalytic subunit p110α and the regulatory subunit p85 undergo cancer-specific gain-of-function mutations that lead to enhanced enzymatic activity, ability to signal constitutively, and oncogenicity.
Peter K, Vogt +7 more
openaire +2 more sources
Requirement of the FATC domain of protein kinase Tel1 for localization to DNA ends and target protein recognition [PDF]
, 2015 Two large phosphatidylinositol 3-kinase-related protein kinases (PIKKs), ATM and ATR, play a central role in the DNA damage response pathway. PIKKs contain a highly conserved extreme C-terminus called the FRAP-ATM-TRRAP-C-terminal (FATC) domain.
Ghosh, A. +5 more
core +1 more source