Results 151 to 160 of about 192,633 (279)

Phosphatidylinositol and phosphatidylinositol-3-phosphate activate HOPS to catalyze SNARE assembly, allowing small headgroup lipids to support the terminal steps of membrane fusion. [PDF]

Mol Biol Cell, 2021
Torng T, Wickner W.
europepmc   +1 more source

Phosphoinositides and Charcot-Marie-Tooth disease: New keys to old questions [PDF]

, 2018
.: Recent research into the genetic basis and the molecular disease mechanisms of Charcot-Marie-Tooth disease (CMT), also called hereditary motor and sensory neuropathies, has highlighted phosphoinositides, membrane-tethered phosphorylated metabolites of
Suter, U.
core  

A Combined Colon Organoid‐Sensory Neuron Model Reveals Epithelial Contribution to Moringin Efficacy Against Painful Inflammatory Bowel Disease

Phytotherapy Research, EarlyView.
Experimental workflow and main findings of the study. ABSTRACT Visceral pain is a major symptom of inflammatory bowel diseases (IBDs), requiring effective treatment strategies. Gut epithelium, beyond maintaining barrier integrity and microbiota homeostasis, modulates neurosensorial circuitries, influencing visceral sensitivity.
Francesco Margiotta, Elena Lucarini, Alessandra Toti, Maria Giovanna Cataldi, Clara Ciampi, Gina Rosalinda De Nicola, Lorenzo Di Cesare Mannelli, Carla Ghelardini   +7 more
wiley   +1 more source

Identification and structural characterisation of a partially arabinosylated lipoarabinomannan variant isolated from a Corynebacterium glutamicum ubiAmutant [PDF]

, 2007
Arabinan polysaccharide side-chains are present in both Mycobacterium tuberculosis and Corynebacterium glutamicum in the heteropolysaccharide arabinogalactan (AG), and in M. tuberculosis in the lipoglycan, lipoarabinomannan (LAM).
Alderwick, Luke J., Besra, Gurdyal S, Dell, Anne, Eggeling, Lothar, Gilleron, Martine, Giordano, Assunta, Hitchen, Paul, Krumbach, Karin, Mishra, Arun K., Morris, Howard R., Nigou, Jerome, Tatituri, Raju Venkata Veera   +11 more
core  

Mechanistic Insight Into Ionizable Cationic Lipid‐Mediated Endosomal Escape via Transient Lipid Complexes

Small, EarlyView.
Coarse‐grained simulations show that the formation of transient anionic–cationic lipid pairs regulates the rate‐limiting step for the lamellar‐to‐hexagonal phase transition in mixtures of anionic and cationic lipids mimicking the endosomal membrane after fusion with lipid‐based nanoparticles, thus playing an important role in the endosomal escape of ...
David Noel Zimmer, Friederike Schmid, Giovanni Settanni   +2 more
wiley   +1 more source

Tributyltin Protumorigenic Effects Targeting Prostate Cancer Cell Metabolism, Proliferation, Migration, and Invasion

Environmental Toxicology, EarlyView.
ABSTRACT Prostate cancer (PCa) is an endocrine‐related cancer highly dependent on androgenic signaling. Beyond hormone dependence, extrinsic factors play a significant role in the risk of developing PCa, which raises concern about the influence of environmental compounds such as endocrine‐disrupting chemicals (EDCs). Tributyltin (TBT) is an EDC used in
Mariana Feijó, Luís P. Brás, Catarina M. D. Serra, Lara R. S. Fonseca, Sara Correia, Bruno J. Pereira, Ana P. Duarte, Henrique J. Cardoso, Cátia V. Vaz, Sílvia Socorro   +9 more
wiley   +1 more source

PfPI3K inhibition reversed artemisinin resistance by increasing ROS and ubiquitinated protein levels in Plasmodium falciparum

Communications Biology
Phosphatidylinositol-3-phosphate (PI3P) is the key mediator of resistance to artemisinin drugs (ARTs) and that phosphatidylinositol 3-kinase (PfPI3K) is a promising target for eliminating ARTs resistance.
Nan Shi, Rongrong Wang, Tanjiangyue Yu, Jiaqi Yang, Lina Chen, Qingxia Li, Yujie Li, Shuqiu Zhang   +7 more
doaj   +1 more source

An effector of phosphatidylinositol 3-kinase activity promotes Rickettsia rickettsii virulence by enhancing autophagy

mBio
To establish an intracellular niche conductive to growth, some bacterial pathogens deliver virulence factors that modulate phosphoinositides (PIPs) metabolism.
Dan Huang, Xuan OuYang, Zhihan Peng, Dong Chen, Lei Song, Zhao-Qing Luo   +5 more
doaj   +1 more source

Phosphatidylinositol 3-Phosphate-interacting Domains in PIKfyve [PDF]

Journal of Biological Chemistry, 2002
Diego Sbrissa, Ognian C. Ikonomov, Assia Shisheva   +2 more
openaire   +1 more source

The Mechanism of NLRP3 Inflammasome Activation and Its Roles in Chronic Rhinosinusitis

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT NLRP3 (NLR family pyrin domain containing 3) is one of the crucial receptors in pathogen recognition receptor (PRR) families which can recognize the pathogen‐associated molecular patterns (PAMPs) and the damage‐associated molecular patterns (DAMPs), thus triggering innate immune response. After NLRP3 activation, it recruits the adaptor protein
Dong‐Lin Li, Yue Li, Yan‐Jie Jiang, Ge‐Hua Zhang, Li‐Hong Chang   +4 more
wiley   +1 more source