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The Regulation and Function of Hippo/YAP Pathway in Cancer
The FASEB Journal, Volume 40, Issue 7, 15 April 2026.Hippo/YAP pathway signaling plays critical roles in the progression of multiple cancer types. This review summarizes current knowledge of Hippo/YAP pathway regulation and function in cancer. We discuss the core components of the Hippo/YAP pathway; its crosstalk with other signaling pathways; regulation by non‐coding RNAs; roles of YAP signaling in ...
Chinmoy Ghosh +3 more
wiley +1 more source
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Phosphatidylinositol‐4‐phosphate: The Golgi and beyond
BioEssays, 2013Initially identified as a key phosphoinositide that controls membrane trafficking at the Golgi complex, phosphatidylinositol‐4‐phosphate (PI4P) has emerged as a key molecule in the regulation of a diverse array of cellular functions. In this review we will discuss selected examples of the findings that in the last few years have significantly increased
DE MATTEIS, Maria Antonietta +2 more
openaire +3 more sources
The phosphatidylinositol 4-phosphate 5-kinase family
Advances in Enzyme Regulation, 1996The existence of a PIP5K family of enzymes has been suggested by Western blotting and purification of numerous PIP5Ks from various tissues and cell types. The erythrocyte has at least two PIP5Ks, named PIP5KI and PIP5KII, while the brain appears to have even more isoforms.
J C, Loijens +3 more
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Journal of Cellular Biochemistry, 2006
AbstractType I phosphatidylinositol 4‐phosphate 5‐kinase (PI4P5K) catalyzes the phosphorylation of phosphatidylinositol 4 phosphate [PI(4)P] at carbon 5, producing phosphatidylinositol 4,5 bisphosphate [PI(4,5)P2]. Phosphatidic acid (PA) activates PI4P5K in vitro and plays a central role in the activation of PIP5K pathways in vivo.
Marta, Jarquin-Pardo +4 more
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AbstractType I phosphatidylinositol 4‐phosphate 5‐kinase (PI4P5K) catalyzes the phosphorylation of phosphatidylinositol 4 phosphate [PI(4)P] at carbon 5, producing phosphatidylinositol 4,5 bisphosphate [PI(4,5)P2]. Phosphatidic acid (PA) activates PI4P5K in vitro and plays a central role in the activation of PIP5K pathways in vivo.
Marta, Jarquin-Pardo +4 more
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Phosphatidylinositol 4-Kinase and Phosphatidylinositol 4-Phosphate 5-Kinase Assays
2013Inositol lipid kinases are perhaps the easiest and most straightforward enzymes in the phosphoinositide pathway to analyze. In addition to monitoring lipid kinase-specific activity, lipid kinase assays can be used to quantify the inositol lipids present in isolated membranes (Jones et al., Methods Mol Biol 462:75-88, 2009).
Yang Ju, Im +4 more
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Biochemical and Biophysical Research Communications, 1985
Phosphatidylinositol 4,5-bisphosphate (PIP2) is enzymatically produced when high speed supernatant fraction from bovine retina is incubated with [gamma-32P]ATP and phosphatidylinositol 4-phosphate (PIP) as substrates. Exogenously added PIP2 inhibits PIP kinase activity 50% at equimolar concentrations of product and substrate.
L A, Van Rooijen +2 more
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Phosphatidylinositol 4,5-bisphosphate (PIP2) is enzymatically produced when high speed supernatant fraction from bovine retina is incubated with [gamma-32P]ATP and phosphatidylinositol 4-phosphate (PIP) as substrates. Exogenously added PIP2 inhibits PIP kinase activity 50% at equimolar concentrations of product and substrate.
L A, Van Rooijen +2 more
openaire +2 more sources
Phosphatidylinositol 4-kinases, phosphatidylinositol 4-phosphate and cancer
Cancer Letters, 2012This article focuses on the emerging roles for phosphatidylinositol 4-phosphate and the phosphatidylinositol 4-kinases in cancer. Phosphatidylinositol 4-phosphate is a common substrate for both the phosphatidylinositol 3-kinase and phospholipase C pathways, and has been implicated in the membrane targeting of proteins such as Girdin/GIV and OSBP ...
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The Journal of Immunology, 1988
Abstract Phosphodiesteric cleavage of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) is required for transmembrane signaling by chemoattractants in human polymorphonuclear leukocytes (PMN). Considering the importance of PtdIns-4,5-P2 as a reservoir for second messenger substances, we have characterized the enzyme system that ...
M C, Pike, C, Arndt
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Abstract Phosphodiesteric cleavage of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) is required for transmembrane signaling by chemoattractants in human polymorphonuclear leukocytes (PMN). Considering the importance of PtdIns-4,5-P2 as a reservoir for second messenger substances, we have characterized the enzyme system that ...
M C, Pike, C, Arndt
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Cell Calcium, 1982
Recent years have seen a rapid accumulation of information which relates to the idea that receptor-controlled effects on inositol lipid metabolism might somehow be involved in the control of stimulated cells (see refs 1–14 for reviews). Most of these studies have been concerned only with phosphatidylinositol (PtdIns) and have tended to ignore the ...
P, Downes, R H, Michell
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Recent years have seen a rapid accumulation of information which relates to the idea that receptor-controlled effects on inositol lipid metabolism might somehow be involved in the control of stimulated cells (see refs 1–14 for reviews). Most of these studies have been concerned only with phosphatidylinositol (PtdIns) and have tended to ignore the ...
P, Downes, R H, Michell
openaire +2 more sources