Results 161 to 170 of about 195,175 (290)

IL‐15 Plus Thymosin α1 Reduces Senescent Hepatic CD8+ T Cells in Hepatocellular Carcinoma via PI3K/AKT Suppression

Journal of Gastroenterology and Hepatology, EarlyView.
Combined IL‐15 and thymosin α1 therapy reverses CD8+ T cell senescence in hepatocellular carcinoma via a “supply and boost” strategy. Tα1 restores thymic naïve T cell output, while IL‐15 enhances peripheral effector function. Mechanistically, this combination suppresses overactivated PI3K/AKT signaling, restoring antitumor immunity and prolonging ...
Fengtian Wu, Zixuan Guo, Jun Guan, Jia Xu, Yao Chen, Zhi Chen   +5 more
wiley   +1 more source

Structure of Mycobacterium tuberculosis phosphatidylinositol phosphate synthase reveals mechanism of substrate binding and metal catalysis. [PDF]

Commun Biol, 2019
Grāve K, Bennett MD, Högbom M.
europepmc   +1 more source

Immune Evasion of Helicobacter pylori and Extra‐Gastric Cancer Risk

Journal of Gastroenterology and Hepatology, EarlyView.
ABSTRACT Helicobacter pylori (H. pylori) is a group 1 gastric carcinogen that plays a significant role in extra‐gastric digestive system cancers. H. pylori disrupts host cell homeostasis through expression of virulence factors leading to immune evasion as well as persistent gastric mucosal colonization. H. pylori infection has been shown to play a role
Evren Doruk Engin, Ayse Basak Engin, Atilla Engin   +2 more
wiley   +1 more source

Phosphoinositide 3-kinase pathways and autophagy require phosphatidylinositol phosphate kinases. [PDF]

Adv Biol Regul, 2018
Choi S, Houdek X, Anderson RA.
europepmc   +1 more source

The transcription factors TaABI4 and TaNAC‐A1 fine‐tune TaCYP94‐A1 transcription to modulate seed dormancy in wheat

Journal of Integrative Plant Biology, EarlyView.
A module involving the transcription factors TaABI4 and TaNAC‐A1, and the cytochrome P450 TaCYP94‐A1 precisely regulates seed dormancy levels through plant hormone crosstalk, providing targets for improving resistance to pre‐harvest sprouting in wheat.
Litian Zhang, Yuhui Fang, Yunfei Zhou, Xianlai Nie, Shujun Cao, Wei Gao, Yu Wang, Lianghua Dai, Lin Ye, Jie Lu, Chuanxi Ma, Cheng Chang, Haiping Zhang   +12 more
wiley   +1 more source

Type I gamma phosphatidylinositol phosphate kinase i5 suppresses YAP1 signaling. [PDF]

J Biol Chem
Ghosh C, Kakar R, Bavuso M, Wang H, Sun Y.   +4 more
europepmc   +1 more source

Type Iγ phosphatidylinositol phosphate kinase promotes tumor growth by facilitating Warburg effect in colorectal cancer. [PDF]

EBioMedicine, 2019
Peng W, Huang W, Ge X, Xue L, Zhao W, Xue J.   +5 more
europepmc   +1 more source

Phosphatidylinositol-3-phosphate (PI3P) [PDF]

Science-Business eXchange, 2010
openaire   +1 more source

Systemic, Lifestyle and Environmental Modifying Factors in the Pathogenesis of Periodontitis

Journal of Periodontal Research, EarlyView.
A variety of impacting factors in the pathogenesis of periodontitis exist, including systemic, lifestyle, and environmental factors. This review highlights the manifold mechanistic aspects of the link between the pathogenesis of periodontitis, addressing these numerous factors to supplement the long‐standing knowledge of the progression of the disease.
Groeger Sabine Elisabeth, Zhou Yuxi, Yong Jiawen, Wang Lei, Ruf Sabine, Meyle Joerg   +5 more
wiley   +1 more source

Ergosterol-induced immune response in barley involves phosphorylation of phosphatidylinositol phosphate metabolic enzymes and activation of diterpene biosynthesis. [PDF]

New Phytol
Saake P, Brands M, Endeshaw AB, Stolze SC, Westhoff P, Balcke GU, Hensel G, Holton N, Zipfel C, Tissier A, Nakagami H, Zuccaro A.   +11 more
europepmc   +1 more source