Results 151 to 160 of about 195,175 (290)

Membrane rafts in T cell activation: A spotlight on CD28 costimulation [PDF]

, 2017
Abrahamsen, Acuto, Ambach, Asanov, August, Bi, Billadeau, Bjørgo, Byrum, Chiang, Chuang, Comrie, Davis, Dennehy, Dupré, Dustin, Eggeling, Esensten, Fischer, Garçon, Gaus, Golub, Gri, Harada, Harder, Harding, Hayashi, Head, Holdorf, Hui, June, Kabouridis, Kallikourdis, Kamphorst, Kenworthy, Kim, Kong, Krawczyk, Kündig, Lasserre, Ledbetter, Lee, Liang, Lichtenberg, Lingwood, Liu, Marengère, Martin, Mayor, Monks, Muscolini, Muscolini, Muscolini, Nakamura, Owen, Paccani, Pagès, Pike, Pike, Pike, Pizzo, Porciello, Porciello, Pralle, Raab, Raab, Raychaudhuri, Resh, Roncagalli, Round, Ruppelt, Russell, Salazar-Fontana, Salomon, Sanchez-Lockhart, Schütz, Shahinian, Sherman, Simons, Simons, Subczynski, Tavano, Tavano, Varma, Varshney, Villalba, Villalba, Viola, Viola, Viola, Viola, von Haller, Watanabe, Yokosuka, Zhang, Zhang   +95 more
core   +1 more source

Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt

British Journal of Pharmacology, EarlyView.
Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown, Alan Armstrong, David J. Mann   +2 more
wiley   +1 more source

Cannabidiol and cannabigerol ameliorate steatotic liver disease via phosphocreatine buffering and lysosomal restoration

British Journal of Pharmacology, EarlyView.
Cannabidiol (CBD) and cannabigerol (CBG) alleviate hepatic steatosis in obese mice by shifting energy buffering towards phosphocreatine and enhancing lysosomal lipid degradation and trafficking. These effects are associated with increased creatine kinase activity and lysobisphosphatidic acid (LBPA) levels, highlighting a previously unrecognised ...
Radka Kočvarová, Shahar Azar, Bella Agranovich, Ifat Abramovich, Saveliy Kirillov, Alina Nemirovski, Saja Baraghithy, Inbar Plaschkes, Emmanuelle Merquiol, Alexander Rouvinski, Galia Blum, Liad Hinden, Joseph Tam   +12 more
wiley   +1 more source

Therapeutic potential of small molecules that block receptor‐induced Kv7/M‐current suppression in neuroprotection, seizures, and pain

British Journal of Pharmacology, EarlyView.
Receptor‐induced Kv7/M‐current suppression increases neuronal activity and contributes to pathology of several conditions. A new class of Kv7 modulators identified in this study attenuates M‐current suppression and shows therapeutic effects. Abstract Background and Purpose Neuronal Kv7 channels generate low voltage–gated potassium currents known as the
Young Woo Kim, Pavan Kumar Behara, Lamees Alhassen, Cindy Wong, Olivier Civelli, Naoto Hoshi   +5 more
wiley   +1 more source

ITGA5 as a Dual Regulator of Epithelial‐Mesenchymal Transition and Epithelial Cell Anoikis Resistance: Functional Validation and Drug Prediction

Cell Proliferation, EarlyView.
Proteomics and functional validation reveal ITGA5 as a dual promoter of epithelial‐mesenchymal transition and anoikis resistance in human bronchial epithelium: targeting ITGA5 represents a novel therapeutic strategy for asthma airway remodelling. ABSTRACT Airway remodelling is a major contributor to persistent airflow limitation and irreversible lung ...
Ting Wang, Ling Rao, Xiaofang Li, Miaofen Zhang, Huiting Huang, Zhiyan Luo, Gang Liao, Yong Jiang, Shaofeng Zhan, Qiong Liu, Xiufang Huang   +10 more
wiley   +1 more source

Cold‐Induced Lipidomic Remodelling Is Associated With Brown Adipose Tissue Mean Radiodensity in Humans

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims Cold exposure activates brown adipose tissue (BAT) and promotes thermogenic and metabolic adaptations. While BAT activation has been linked to improved cardiometabolic health, how acute cold exposure reshapes the circulating lipidome in humans remains incompletely understood.
Yu Zhang, Borja Martinez‐Tellez, Alida Kindt, Nicolas Drouin, Amy Harms, Thomas Hankemeier, Jonatan R. Ruiz, Lucas Jurado‐Fasoli   +7 more
wiley   +1 more source

Opposing roles of DGAT‐mediated lipid droplet biogenesis in the regulation of ferroptosis sensitivity

The FEBS Journal, EarlyView.
Ferroptosis is driven by unrestricted peroxidation of polyunsaturated fatty acyl (PUFA) chains in membrane phospholipids. In triple‐negative breast cancer cells, lipid droplets (LDs) sequester dietary PUFAs, limiting their incorporation into membrane phospholipids, preventing mitochondrial damage, and reducing lipid peroxidation and ferroptosis.
Ana Kump, Leja Perne, Špela Koren, Eva Jarc Jovičić, Nastja Feguš, Carina Pinto Kozmus, Michele Wölk, Kristyna Brejchova, Maria Fedorova, Ondrej Kuda, Toni Petan   +10 more
wiley   +1 more source

An amphitropic cAMP-binding protein in yeast mitochondria. [PDF]

, 1989
Bandlow W., Baranska J., Blok M., Brugge J., Burn P., Burn P., Cascales S. C., Cobon G. S., Cobon G. S., Cornell R., Courtneidge S. A., Cross G. A. M., Dils R. R., Dygas A., Gillfillan A. M., Guarnieri M., Hixson C. S., Hostetler K. Y., Jelsema C. L., Kraft A. S., Lassing I., Lassing I., Low M. G., Megli F. M., Meyer R. K., Muller G., Muller G., Muller G., Muller G., Nishizuka Y., Pelech S. L., Radika R., Rodel G., Rotman A., Schmidt M. F. G., Sefton B. M., Sleight R., Terce F., Towbin H., Wirtz K. W. A., Wirtz K. W. A., Wojtczak L., Yaffe M., Zborowski J.   +43 more
core   +3 more sources

Investigation into the delivery and evaluation of a unique Avena sativa (Oat) Lipid Extract on skin barrier using LC‒MS/MS, Raman spectroscopy, immunostaining analysis and skin efficacy

International Journal of Cosmetic Science, EarlyView.
Abstract Objectives Oat lipids are rich in ceramides. In this investigation, we analysed the delivery of a specific Oat Lipid Extract derived from Avena sativa, comprising ‘skin identical’ ratios of fatty acids, ceramides and cholesterol/sterol. This investigation is the first reported investigation of oat lipids utilizing Raman spectroscopy for the ...
E. Gombert, C. Dewis
wiley   +1 more source

Membrane Recognition and Binding by the Phosphatidylinositol Phosphate Kinase PIP5K1A: A Multiscale Simulation Study. [PDF]

Structure, 2019
Amos STA, Kalli AC, Shi J, Sansom MSP.
europepmc   +1 more source