Results 131 to 140 of about 195,175 (290)

Deciphering the soybean root rot pathogen Phytophthora sojae: Signaling pathways, transcriptional regulation, and effector biology

New Plant Protection, EarlyView.
This review highlights how Phytophthora sojae utilizes unconventional lineage‐specific signaling networks, including unique G protein‐coupled receptor fusions, expanded kinases, and rapidly evolving effectors, to infect soybeans. Understanding these divergent molecular paradigms reveals critical vulnerabilities in this destructive pathogen, offering ...
Min Qiu, Xiaoyi Zhang, Bo Yang, Wenwu Ye, Yuanchao Wang   +4 more
wiley   +1 more source

Innate immunity shapes the persistent transmission of plant viruses by insect vectors

New Plant Protection, EarlyView.
In this review, we focus on two key aspects of the virus–vector interplay: (1) persistently transmitted viruses utilize host factors to overcome transmission barriers; and (2) molecular recognition activates antiviral immunity and subsequent viral counter‐defense. Understanding these interactions offers critical insights for developing novel strategies
Gang Lu, Chuanxi Zhang, Junmin Li
wiley   +1 more source

Association of NGF receptors with membrane rafts in PC12 cells : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Biochemistry at Massey University [PDF]

, 2001
Nerve Growth Factor (NGF) signal transduction is involved in the survival, differentiation and maintenance of neurons through the receptors TrkA and p75NTR. These receptors activate downstream protein kinase cascades that regulate cell survival.
Clements, Shona Marie
core  

Uric Acid in Metabolic Dysfunction‐Associated Steatotic Liver Disease

Portal Hypertension &Cirrhosis, EarlyView.
MASLD is the most prevalent chronic liver disease worldwide, yet effective pharmacological treatments remain limited. Hyperuricemia is now recognized as a key driver of hepatic steatosis, inflammation, and fibrosis, with elevated serum uric acid levels independently predicting hepatocellular carcinoma and liver‐related mortality.
Rong Wang, Zhenyu Liu, Jun Lin, Weijing Zhang, Xianzhi Liu, Tong Zhang   +5 more
wiley   +1 more source

Identification and structural characterisation of a partially arabinosylated lipoarabinomannan variant isolated from a Corynebacterium glutamicum ubiAmutant [PDF]

, 2007
Arabinan polysaccharide side-chains are present in both Mycobacterium tuberculosis and Corynebacterium glutamicum in the heteropolysaccharide arabinogalactan (AG), and in M. tuberculosis in the lipoglycan, lipoarabinomannan (LAM).
Alderwick, Luke J., Besra, Gurdyal S, Dell, Anne, Eggeling, Lothar, Gilleron, Martine, Giordano, Assunta, Hitchen, Paul, Krumbach, Karin, Mishra, Arun K., Morris, Howard R., Nigou, Jerome, Tatituri, Raju Venkata Veera   +11 more
core  

The continuing significance of chiral agrochemicals

Pest Management Science, Volume 81, Issue 4, Page 1697-1716, April 2025.
In the time frame 2018–2023, around 43% of the 35 chiral agrochemicals introduced to the market (herbicides, fungicides, insecticides, acaricides, and nematicides) contain one or more stereogenic centers in the molecule, and almost 69% of them have been marketed as racemic mixtures of enantiomers or stereoisomers.
Peter Jeschke
wiley   +1 more source

The role of myotubularin-related lipid phosphatases in cancer pathogenesis

Experimental and Molecular Pathology
Myotubularin-related proteins (MTMRs) comprise a family of lipid phosphatases using phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate as their substrate.
Lenka Doubravská, Marie Macůrková
doaj   +1 more source

Structural and Functional Characterization of Phosphatidylinositol-Phosphate Biosynthesis in Mycobacteria. [PDF]

J Mol Biol, 2020
Belcher Dufrisne M, Jorge CD, Timóteo CG, Petrou VI, Ashraf KU, Banerjee S, Clarke OB, Santos H, Mancia F.   +8 more
europepmc   +1 more source

Epigallocatechin‐3‐Gallate Suppresses Glioma by Targeting Integrin αvβ3/FAK/ERK Signaling Axis and Matrix Metalloproteinases

Phytotherapy Research, EarlyView.
EGCG suppresses glioma progression by targeting integrin αvβ3/FAK/ERK signaling and inhibiting MMP‐2/MMP‐9‐mediated ECM degradation, thereby blocking proliferation, migration, invasion, and promoting apoptosis. ABSTRACT Epigallocatechin‐3‐gallate (EGCG), the most abundant and biologically active catechin in green tea, has been widely reported to ...
Rui Sun, Yonghan Pan, Ning Yang, Bing Kang, Hong Xiao, Xianglong Tang, Taiping Li, Mengjie Zhao   +7 more
wiley   +1 more source

A Combined Colon Organoid‐Sensory Neuron Model Reveals Epithelial Contribution to Moringin Efficacy Against Painful Inflammatory Bowel Disease

Phytotherapy Research, EarlyView.
Experimental workflow and main findings of the study. ABSTRACT Visceral pain is a major symptom of inflammatory bowel diseases (IBDs), requiring effective treatment strategies. Gut epithelium, beyond maintaining barrier integrity and microbiota homeostasis, modulates neurosensorial circuitries, influencing visceral sensitivity.
Francesco Margiotta, Elena Lucarini, Alessandra Toti, Maria Giovanna Cataldi, Clara Ciampi, Gina Rosalinda De Nicola, Lorenzo Di Cesare Mannelli, Carla Ghelardini   +7 more
wiley   +1 more source