Results 111 to 120 of about 195,175 (290)

Phosphatidylinositol 5 Phosphate 4-Kinase Regulates Plasma-Membrane PIP3 Turnover and Insulin Signaling

Cell Reports, 2019
Summary: Phosphatidylinositol 3,4,5-trisphosphate (PIP3) generation at the plasma membrane is a key event during activation of receptor tyrosine kinases such as the insulin receptor required for normal growth and metabolism. We report that in Drosophila,
Sanjeev Sharma, Swarna Mathre, Visvanathan Ramya, Dhananjay Shinde, Padinjat Raghu   +4 more
doaj   +1 more source

Rational Design and Synthesis of D-galactosyl Lysophospholipids as Selective Substrates and non-ATP-competitive Inhibitors of Phosphatidylinositol Phosphate Kinases. [PDF]

Chemistry, 2023
Sun M, Zhang C, Sui D, Yang C, Pyeon D, Huang X, Hu J.   +6 more
europepmc   +1 more source

Phosphatidylinositol 4‐phosphate dynamics during phagocytosis

The FASEB Journal, 2015
Phosphoinositide levels undergo acute changes during the course of phagocytosis; phosphatidylinositol 4,5‐ bis phosphate [PtdIns(4,5)P 2 ], phosphatidylinositol 3,4,5‐ tris phosphate and phosphatidylinositol 3 ...
Roni Levin, Gerald Hammond, Tamas Balla, Gregory Fairn, Sergio Grinstein   +4 more
openaire   +1 more source

Targeting type Iγ phosphatidylinositol phosphate kinase overcomes oxaliplatin resistance in colorectal cancer. [PDF]

Theranostics, 2022
Yu M, Wang H, Zhao W, Ge X, Huang W, Lin F, Tang W, Li A, Liu S, Li RK, Jiang SH, Xue J.   +11 more
europepmc   +1 more source

Phosphatidylserine polarization is required for proper Cdc42 localization and for development of cell polarity. [PDF]

, 2010
We used genetically-encoded fluorescent probes to visualize the distribution of phosphatidylserine (PS) in live S. cerevisiae. The majority of the PS was found to reside in the cytosolic leaflet of the plasma membrane.
Gregory Fairn, Sergio Grinstein
core   +1 more source

Metabolomic and lipidomic signatures of Helicobacter pylori infection: Unveiling biochemical pathways associated with neurodegeneration

iMetaOmics, EarlyView.
Our study employed an integrated lipidomics and metabolomics approach to elucidate Helicobacter pylori‐driven metabolic perturbations along the gut–brain axis. H. pylori infection was established in gastric epithelial (AGS) cells, and the resulting conditioned media (secretome) was collected and exposed to neuronal (IMR‐32) cells.
Meenakshi Kandpal, Tarun Prakash Verma, Siddharth Singh, Hamendra Parmar, Hem Chandra Jha   +4 more
wiley   +1 more source

Downregulation of PIP4K2C inhibits the breast cancer cell proliferation, migration and invasion

Translational Oncology
Phosphoinositide signaling pathway has garnered significant attention in recent years due to its implication in metabolic alterations associated with various human diseases, including breast cancer.
Yue Jin, Jian Xue, Xinyue Li, Xiaoli Zhong   +3 more
doaj   +1 more source

Gephyrin palmitoylation and oligomerization in synaptic plasticity, membrane recruitment and proteostasis [PDF]

, 2012
Efficient signal transmission in the central nervous system is essential for higher brain functions. Inhibitory signaling in the brain primarily takes place at GABAergic (γ-aminobutyric acid) synapses and balances the activity of excitatory synapses ...
Dejanovic, Borislav
core  

Functionally complementary bacterial inoculant coordinates arbuscular mycorrhizal fungi to improve Angelica sinensis root yield and quality

iMetaOmics, EarlyView.
Comprehensive understanding of how diverse PGPR strains enhance the rhizosphere microenvironment remains a considerable challenge. Here, we provide experimental evidence that a functionally synergistic composite microbial formulation can markedly enhance growth performance and improve the quality attributes in Angelica sinensis.
Zongyu Zhang, Yun Wang, Jiecai Zhao, Gaofeng Chen, Andéole Niyongabo Turatsinze, Liang Yue, Yuan Tian, Xiaofan Xie, Ailing Ye, Meilan Zhang, Lingling Wu, Zengxiang Guo, Yubao Zhang, Ruoyu Wang   +13 more
wiley   +1 more source

Comparative gene identification 58/α/β hydrolase domain 5 lacks lysophosphatidic acid acyltransferase activity

Journal of Lipid Research, 2014
Mutations in the gene encoding comparative gene identification 58 (CGI-58)/α/β hydrolase domain 5 (ABHD5) cause Chanarin-Dorfman syndrome, characterized by excessive triacylglycerol storage in cells and tissues.
Derek McMahon, Anna Dinh, Daniel Kurz, Dharika Shah, Gil-Soo Han, George M. Carman, Dawn L. Brasaemle   +6 more
doaj   +1 more source