Transcription factor EB regulates phosphatidylinositol-3-phosphate levels that control lysosome positioning in the bladder cancer model [PDF]
Communications Biology, 2023 In aggressive bladder cancer cells, the transcription factor EB is activated, leading to increased endosomal phosphatidylinositol-3-phosphate levels and lysosome dispersion to the cells’ periphery.
Pallavi Mathur +7 more
doaj +2 more sources
The phosphatidylinositol 3-phosphate effector FYVE3 regulates FYVE2-dependent autophagy in Arabidopsis thaliana [PDF]
Frontiers in Plant Science, 2023 Phosphatidylinositol 3-phosphate (PI3P) is a signaling phospholipid that play a key role in endomembrane trafficking, specifically autophagy and endosomal trafficking.
Jeong Hun Kim +4 more
doaj +2 more sources
Transgenic Soybeans Expressing Phosphatidylinositol-3-Phosphate-Binding Proteins Show Enhanced Resistance Against the Oomycete Pathogen Phytophthora sojae [PDF]
Frontiers in Microbiology, 2022 Oomycete and fungal pathogens cause billions of dollars of damage to crops worldwide annually. Therefore, there remains a need for broad-spectrum resistance genes, especially ones that target pathogens but do not interfere with colonization by beneficial
Emily E. Helliwell +13 more
doaj +2 more sources
Endosomal phosphatidylinositol 3-phosphate controls synaptic vesicle cycling and neurotransmission. [PDF]
EMBO J, 2022 Neural circuit function requires mechanisms for controlling neurotransmitter release and the activity of neuronal networks, including modulation by synaptic contacts, synaptic plasticity, and homeostatic scaling. However, how neurons intrinsically monitor and feedback control presynaptic neurotransmitter release and synaptic vesicle (SV) recycling to ...
Liu GT +8 more
europepmc +3 more sources
Phosphatidylinositol 3-phosphate and Hsp70 protect Plasmodium falciparum from heat-induced cell death [PDF]
eLife, 2020 Phosphatidylinositol 3-phosphate (PI(3)P) levels in Plasmodium falciparum correlate with tolerance to cellular stresses caused by artemisinin and environmental factors. However, PI(3)P function during the Plasmodium stress response was unknown.
Kuan-Yi Lu +5 more
doaj +2 more sources
Early Endosomal Vps34-Derived Phosphatidylinositol-3-Phosphate Is Indispensable for the Biogenesis of the Endosomal Recycling Compartment [PDF]
Cells, 2022 Phosphatidylinositol-3-phosphate (PI3P), a major identity tag of early endosomes (EEs), provides a platform for the recruitment of numerous cellular proteins containing an FYVE or PX domain that is required for PI3P-dependent maturation of EEs.
Marina Marcelić +4 more
doaj +2 more sources
In vitro reconstitution of Sgk3 activation by phosphatidylinositol 3-phosphate. [PDF]
J Biol Chem, 2021 Serum- and glucocorticoid-regulated kinase 3 (Sgk3) is a serine/threonine protein kinase activated by the phospholipid phosphatidylinositol 3-phosphate (PI3P) downstream of growth factor signaling via class I phosphatidylinositol 3-kinase (PI3K) signaling and by class III PI3K/Vps34-mediated PI3P production on endosomes.
Pokorny D +4 more
europepmc +4 more sources
Membrane Binding of Neuronal Calcium Sensor-1: Highly Specific Interaction with Phosphatidylinositol-3-Phosphate [PDF]
Biomolecules, 2020 Neuronal calcium sensors are a family of N-terminally myristoylated membrane-binding proteins possessing a different intracellular localization and thereby targeting unique signaling partner(s).
Viktoriia E. Baksheeva +11 more
doaj +2 more sources
Endosomal Phosphatidylinositol-3-Phosphate-Associated Functions Are Dispensable for Establishment of the Cytomegalovirus Pre-Assembly Compartment but Essential for the Virus Growth [PDF]
Life, 2021 Murine cytomegalovirus (MCMV) initiates the stepwise establishment of the pre-assembly compartment (pre-AC) in the early phase of infection by the expansion of the early endosome (EE)/endosomal recycling compartment (ERC) interface and relocation of the ...
Marina Marcelić +5 more
doaj +2 more sources
Phosphatidylinositol 4-phosphate and phosphatidylinositol 3-phosphate regulate phagolysosome biogenesis. [PDF]
Proc Natl Acad Sci U S A, 2015 Significance Phagocytes are key to innate immunity, as they ingest, kill, and degrade foreign particles, such as microbes. Particle uptake results in the formation of phagosomes that eventually fuse with lysosomes, the main degradative compartments in cells.
Jeschke A +10 more
europepmc +5 more sources