Formation of phosphatidylinositol 3-phosphate by isomerization from phosphatidylinositol 4-phosphate. [PDF]
Proceedings of the National Academy of Sciences, 1991 We have synthesized phosphatidylinositol 3-phosphate from phosphatidylinositol 4-phosphate by using diisopropylcarbodiimide to promote migration of the 4-phosphate via a cyclic phosphodiester intermediate. The product was isolated by a thin-layer chromatographic method that depends on the ability of phosphatidylinositol 4-phosphate, but not ...
J P, Walsh, K K, Caldwell, P W, Majerus
openaire +2 more sources
Partial inhibition of class III PI3K VPS-34 ameliorates motor aging and prolongs health span.
PLoS Biology, 2023 Global increase of life expectancy is rarely accompanied by increased health span, calling for a greater understanding of age-associated behavioral decline.
Zhongliang Hu +11 more
doaj +1 more source
Relationship between membrane phosphatidylinositol-4,5-bisphosphate and receptor-mediated inhibition of native neuronal M channels [PDF]
, 2005 The relationship between receptor-induced membrane phosphatidylinositol-4'5'-bisphosphate (PIP2) hydrolysis and M-current inhibition was assessed in single-dissociated rat sympathetic neurons by simultaneous or parallel recording of membrane current and ...
Abogadie, FC +6 more
core +1 more source
A Sec14 domain protein is required for photoautotrophic growth and chloroplast vesicle formation in Arabidopsis thaliana. [PDF]
, 2020 In eukaryotic photosynthetic organisms, the conversion of solar into chemical energy occurs in thylakoid membranes in the chloroplast. How thylakoid membranes are formed and maintained is poorly understood.
Armbruster, Ute +6 more
core +2 more sources
Phosphoinositide Signaling and Mechanotransduction in Cardiovascular Biology and Disease
Frontiers in Cell and Developmental Biology, 2020 Phosphoinositides, which are membrane-bound phospholipids, are critical signaling molecules located at the interface between the extracellular matrix, cell membrane, and cytoskeleton.
Amanda Krajnik +6 more
doaj +1 more source
Characterization of VPS34-IN1, a selective inhibitor of Vps34, reveals that the phosphatidylinositol 3-phosphate-binding SGK3 protein kinase is a downstream target of class III phosphoinositide 3-kinase [PDF]
, 2014 The Vps34 (vacuolar protein sorting 34) class III PI3K (phosphoinositide 3-kinase) phosphorylates PtdIns (phosphatidylinositol) at endosomal membranes to generate PtdIns(3)P that regulates membrane trafficking processes via its ability to recruit a ...
Alessi, Dario R. +10 more
core +3 more sources
Hepatology, EarlyView., 2022 Increased liver content of DHA‐derived small lipid autacoids (i.e resolvin D1 and maresin 1) associates with enhanced mitochondrial oxidative phosphorylation, fatty acid β‐oxidation and bioenergetic metabolic flux. These features provide hepatic protection from steatotic, pro‐inflammatory and fibrogenic insults.
Cristina López‐Vicario +12 more
wiley +1 more source
Risk1, a Phosphatidylinositol 3-Kinase Effector, Promotes
mBio, 2020 To establish a habitable intracellular niche, various pathogenic bacteria secrete effectors that target intracellular trafficking and modulate phosphoinositide (PI) metabolism.
Oliver H. Voss +6 more
doaj +1 more source
Autophagy induced by calcium phosphate precipitates involves endoplasmic reticulum membranes in autophagosome biogenesis. [PDF]
PLoS ONE, 2012 Calcium can play an important role in the regulation of autophagy. We previously reported that exogenously introduced calcium in the form of calcium phosphate precipitates (CPP) induces autophagy.
Xi Chen +6 more
doaj +1 more source
Stress-induced Synthesis of Phosphatidylinositol 3-Phosphate in Mycobacteria [PDF]
Journal of Biological Chemistry, 2010 Phosphoinositides play key roles in regulating membrane dynamics and intracellular signaling in eukaryotic cells. However, comparable lipid-based signaling pathways have not been identified in bacteria. Here we show that Mycobacterium smegmatis and other Actinomycetes bacteria can synthesize the phosphoinositide, phosphatidylinositol 3-phosphate (PI3P).
Yasu S, Morita +9 more
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