Results 51 to 60 of about 192,633 (279)
Hepatology, EarlyView., 2022 CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli +13 more
wiley +1 more source
Editorial: Membrane lipids in T cell functions [PDF]
, 2018 Plasma membrane lipids play essential roles in regulating T cell signaling, differentiation, and effector functions. The major lipid species in the plasma membrane are glycerophospholipids, sphingolipids, and sterol lipids.
Tuosto, Loretta, Xu, Chenqi
core +1 more source
Deciphering the roles of phosphoinositide lipids in phagolysosome biogenesis
Communicative & Integrative Biology, 2016 Professional phagocytes engulf microbial invaders into plasma membrane-derived phagosomes. These mature into microbicidal phagolysosomes, leading to killing of the ingested microbe.
Andreas Jeschke, Albert Haas
doaj +1 more source
Membrane contact sites - an interesting species, an interesting mix [PDF]
, 2013 In this issue of EMBO reports, Loewen and colleagues reveal a role for plasma membrane–endoplasmic reticulum contact sites in regulating phosphatidylcholine synthesis in budding ...
Miller, Vicky J, Stephens, David J
core +2 more sources
Myotubularin Regulates Akt-dependent Survival Signaling via Phosphatidylinositol 3-Phosphate [PDF]
Journal of Biological Chemistry, 2011 Myotubularin is a 3-phosphoinositide phosphatase that is mutated in X-linked myotubular myopathy, a severe neonatal disorder in which skeletal muscle development and/or regeneration is impaired. In this report we provide evidence that siRNA-mediated silencing of myotubularin expression markedly inhibits growth factor-stimulated Akt phosphorylation ...
Gina L, Razidlo +2 more
openaire +2 more sources
Nature Communications, 2018 Sorting nexin 3 (SNX3) is a phosphatidylinositol 3-phosphate binding protein that localizes to early endosomes. Here the authors use NMR to resolve SNX3′s membrane interactions, revealing that membrane binding is regulated through phosphorylation of a ...
Marc Lenoir +6 more
doaj +1 more source
Targeting phosphoinositide 3-kinase (PI3K) in head and neck squamous cell carcinoma (HNSCC). [PDF]
, 2018 The landscape of head and neck squamous cell carcinoma (HNSCC) has been changing rapidly due to growing proportion of HPV-related disease and development of new therapeutic agents.
Jung, Kyungsuk +2 more
core +2 more sources
Legionella pneumophila exploits PI(4)P to anchor secreted effector proteins to the replicative vacuole. [PDF]
PLoS Pathogens, 2006 The causative agent of Legionnaires' disease, Legionella pneumophila, employs the intracellular multiplication (Icm)/defective organelle trafficking (Dot) type IV secretion system (T4SS) to upregulate phagocytosis and to establish a replicative vacuole ...
Stefan S Weber +4 more
doaj +2 more sources
The role of myotubularin-related lipid phosphatases in cancer pathogenesis
Experimental and Molecular PathologyMyotubularin-related proteins (MTMRs) comprise a family of lipid phosphatases using phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate as their substrate.
Lenka Doubravská, Marie Macůrková
doaj +1 more source
Yeast and mammalian autophagosomes exhibit distinct phosphatidylinositol 3-phosphate asymmetries [PDF]
Nature Communications, 2014 Phosphatidylinositol 3-kinase is indispensable for autophagy but it is not well understood how its product, phosphatidylinositol 3-phosphate (PtdIns(3)P), participates in the biogenesis of autophagic membranes. Here, by using quick-freezing and freeze-fracture replica labelling, which enables determination of the nanoscale distributions of membrane ...
Jinglei Cheng +7 more
openaire +2 more sources