Phosphatidylinositol-4-phosphate controls autophagosome formation in Arabidopsis thaliana [PDF]
Nature Communications, 2022 Autophagosomes are specialized vesicles that target and deliver cargo to the lytic vacuole. Here the authors show that plasma-membrane derived lipid phosphatidylinositol-4-phosphate supports the assembly and expansion of autophagosomes in ...
Rodrigo Enrique Gomez +9 more
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OSBP is a Major Determinant of Golgi Phosphatidylinositol 4-Phosphate Homeostasis [PDF]
Contact, 2023 The lipid phosphatidylinositol 4-phosphate (PI4P) plays a master regulatory role at Golgi membranes, orchestrating membrane budding, non-vesicular lipid transport and membrane organization.
Colleen P. Doyle +2 more
doaj +5 more sources
Plasma Membrane Phosphatidylinositol 4-Phosphate Is Necessary for Virulence of Candida albicans [PDF]
mBio, 2022 Phosphatidylinositol lipids regulate key processes, including vesicle trafficking and cell polarity. A recent study identified novel roles for phosphatidylinositol 4-phosphate (PI4P) in the plasma membrane of the fungal pathogen Candida albicans ...
James B. Konopka
doaj +2 more sources
SAC1 regulates autophagosomal phosphatidylinositol-4-phosphate for xenophagy-directed bacterial clearance [PDF]
Cell Reports, 2021 Summary: Phosphoinositides are important molecules in lipid signaling, membrane identity, and trafficking that are spatiotemporally controlled by factors from both mammalian cells and intracellular pathogens.
Kai Liu +4 more
doaj +2 more sources
Membrane pools of phosphatidylinositol-4-phosphate regulate KCNQ1/KCNE1 membrane expression [PDF]
Communications Biology, 2021 Braun et al. investigate the effects of PI 4-kinases and their lipid product, PI4P, in KCNQ channel function and sub-cellular localization. These results suggest a possible harmful effect of PI4K inhibition on cardiac electrophysiology and suggest the ...
Chen Braun +3 more
doaj +2 more sources
An acquired phosphatidylinositol 4-phosphate transport initiates T-cell deterioration and leukemogenesis [PDF]
Nature Communications, 2022 The oxysterol-binding protein-related protein 4 (ORP4L) is expressed in T-cell acute lymphoblastic leukemia and is required for leukemogenesis. Here the authors show that ORP4L orchestrates the transport of the phospholipid PI(4)P from Golgi to the ...
Wenbin Zhong +15 more
doaj +2 more sources
Phosphatidylinositol-4-phosphate joins the dance of plant autophagosome formation. [PDF]
Autophagy, 2023 In plants, macroautophagy/autophagy is a key mechanism that contributes to their ability to cope with a wide range of environmental constraints such as drought, nutrient starvation or pathogen resistance. Nevertheless, the molecular mechanisms of plant autophagy, and notably that of autophagosome formation, remain poorly understood.
Gomez RE +5 more
europepmc +3 more sources
Multiphasic dynamics of phosphatidylinositol 4-phosphate during phagocytosis. [PDF]
Mol Biol Cell, 2017 We analyzed the distribution, fate, and functional role of phosphatidylinositol 4-phosphate (PtdIns4P) during phagosome formation and maturation. To this end, we used genetically encoded probes consisting of the PtdIns4P-binding domain of the bacterial effector SidM. PtdIns4P was found to undergo complex, multiphasic changes during phagocytosis.
Levin R +5 more
europepmc +3 more sources
Phosphatidylinositol 4-phosphate and phosphatidylinositol 3-phosphate regulate phagolysosome biogenesis. [PDF]
Proc Natl Acad Sci U S A, 2015 Significance Phagocytes are key to innate immunity, as they ingest, kill, and degrade foreign particles, such as microbes. Particle uptake results in the formation of phagosomes that eventually fuse with lysosomes, the main degradative compartments in cells.
Jeschke A +10 more
europepmc +5 more sources
Phosphatidylinositol 4-phosphate 5-kinases in the regulation of T cell activation [PDF]
Frontiers in Immunology, 2016 Phosphatidylinositol 4,5-biphosphate kinases (PIP5K) are critical regulators of T cell activation being the main enzymes involved in the synthesis of phosphatidylinositol 4,5-biphosphate (PIP2).
Loretta eTuosto +5 more
doaj +2 more sources