Results 21 to 30 of about 195,175 (290)

Stimulation of a glycosyl-phosphatidylinositol-specific phospholipase by insulin and the sulfonylurea, glimepiride, in rat adipocytes depends on increased glucose transport [PDF]

, 1994
. Lipoprotein lipase (LPL) and glycolipidanchored cAMP-binding ectoprotein (Gcel) are modified by glycosyl-phosphatidylinositol (GPI) in rat adipocytes, however, the linkage is potentially unstable. Incubation of the cells with either insulin (0.1-30 nM)
Bandlow, Wolfhard, Dearey, Elisabeth Ann, Korndörfer, Andrea, Müller, Günter   +3 more
core   +3 more sources

The recruitment and activation of phosphatidylinositol 4-phosphate 5-kinases α critically regulate CD28-dependent signaling responses [PDF]

, 2013
CD28 costimulatory receptor is a crucial determinant of the outcome of T lymphocyte activation. The engagement of CD28 by its natural ligands, B7.1/CD80 or B7.2/CD86, expressed on the surface of professional APC, lowers T cell receptor (TCR) activation ...
Camperio, Cristina, Capuano, Cristina, Caristi, S., Galandrini, R., Muscolini, Michela, Piccolella, Enza, Tuosto, Loretta   +6 more
core   +1 more source

An HPLC procedure for separating polyphosphoinositides on hydroxylapatite.

Journal of Lipid Research, 1990
We describe a method for separation of several phosphoinositides by high performance liquid chromatography (HPLC) for the purposes of identification, analysis, and possible purification of cell phospholipid extracts.
LE Boyle, LA Sklar, AE Traynor-Kaplan
doaj   +1 more source

A Sec14 domain protein is required for photoautotrophic growth and chloroplast vesicle formation in Arabidopsis thaliana. [PDF]

, 2020
In eukaryotic photosynthetic organisms, the conversion of solar into chemical energy occurs in thylakoid membranes in the chloroplast. How thylakoid membranes are formed and maintained is poorly understood.
Armbruster, Ute, García-Cerdán, José G, Hertle, Alexander P, Lee, Jimmy J, Niyogi, Krishna K, Shih, Robert, Wong, Winnie   +6 more
core   +2 more sources

Type I Phosphatidylinositol-4-phosphate 5-Kinases Synthesize the Novel Lipids Phosphatidylinositol 3,5-Bisphosphate and Phosphatidylinositol 5-Phosphate [PDF]

Journal of Biological Chemistry, 1998
Inositol phospholipids regulate a variety of cellular processes including proliferation, survival, vesicular trafficking, and cytoskeletal organization. Recently, two novel phosphoinositides, phosphatidylinositol-3,5-bisphosphate (PtdIns-3,5-P2) and phosphatidylinositol- 5-phosphate (PtdIns-5-P), have been shown to exist in cells.
K F, Tolias, L E, Rameh, H, Ishihara, Y, Shibasaki, J, Chen, G D, Prestwich, L C, Cantley, C L, Carpenter   +7 more
openaire   +2 more sources

Phosphoinositide Signaling and Mechanotransduction in Cardiovascular Biology and Disease

Frontiers in Cell and Developmental Biology, 2020
Phosphoinositides, which are membrane-bound phospholipids, are critical signaling molecules located at the interface between the extracellular matrix, cell membrane, and cytoskeleton.
Amanda Krajnik, Joseph A. Brazzo, Kalyanaraman Vaidyanathan, Tuhin Das, Javier Redondo-Muñoz, Javier Redondo-Muñoz, Yongho Bae   +6 more
doaj   +1 more source

Relationship between membrane phosphatidylinositol-4,5-bisphosphate and receptor-mediated inhibition of native neuronal M channels [PDF]

, 2005
The relationship between receptor-induced membrane phosphatidylinositol-4'5'-bisphosphate (PIP2) hydrolysis and M-current inhibition was assessed in single-dissociated rat sympathetic neurons by simultaneous or parallel recording of membrane current and ...
Abogadie, FC, Brown, DA, Filippov, AK, Hughes, S, Marsh, SJ, Tatulian, L, Winks, JS   +6 more
core   +1 more source

PIP4Ks Suppress Insulin Signaling through a Catalytic-Independent Mechanism

Cell Reports, 2019
Summary: Insulin stimulates the conversion of phosphatidylinositol-4,5-bisphosphate (PI(4,5)P2) to phosphatidylinositol-3,4,5-trisphosphate (PI(3,4,5)P3), which mediates downstream cellular responses.
Diana G. Wang, Marcia N. Paddock, Mark R. Lundquist, Janet Y. Sun, Oksana Mashadova, Solomon Amadiume, Timothy W. Bumpus, Cindy Hodakoski, Benjamin D. Hopkins, Matthew Fine, Amanda Hill, T. Jonathan Yang, Jeremy M. Baskin, Lukas E. Dow, Lewis C. Cantley   +14 more
doaj   +1 more source

Phosphatidylinositol(4,5)bisphosphate and Phosphatidylinositol(4)phosphate in Plant Tissues [PDF]

Plant Physiology, 1989
Pea (Pisum sativum) leaf discs or swimming suspensions of Chlamydomonas eugametos were radiolabeled with [(3)H]myo-inositol or [(32)P]Pi and the lipids were extracted, deacylated, and their glycerol moieties removed. The resulting inositol trisphosphate and bisphosphate fractions were examined by periodate degradation, reduction and dephosphorylation ...
R F, Irvine, A J, Letcher, D J, Lander, B K, Drøbak, A P, Dawson, A, Musgrave   +5 more
openaire   +2 more sources

Biology-enabling inositol phosphates, phosphatidylinositol phosphates and derivatives

Natural Product Reports, 2007
This review highlights inositol polyphosphate- and phosphatidylinositol-based small molecule probes that have advanced our understanding of intracellular signalling.
Conway, Stuart J., Miller, Gavin J.
openaire   +4 more sources