Hyperspectral Raman imaging to understand patterns in dried biofluids in Alzheimer's disease
VIEW, EarlyView.Raman spectroscopy is commonly used to identify biomarkers in biological fluids, often focusing on the outer ring of dried droplets due to molecular accumulation from the coffee ring effect. However, this approach may overlook important spectral information, so hyperspectral Raman mapping is used to analyze the entire droplet and identify optimal ...
Eneko Lopez +8 more
wiley +1 more source
Loss of phosphatase activity in myotubularin-related protein 2 is associated with Charcot-Marie-Tooth disease type 4B1 [PDF]
, 2017 Mutations in the gene encoding myotubularin-related protein 2 (MTMR2) are responsible for autosomal recessive Charcot-Marie-Tooth disease type 4B1 (CMT4B1), a severe hereditary motor and sensory neuropathy characterized by focally folded myelin sheaths ...
Berger, Philipp +4 more
core
Autophosphorylation of Type I Phosphatidylinositol Phosphate Kinase Regulates Its Lipid Kinase Activity [PDF]
, 2000 Toshiki Itoh +4 more
openalex +1 more source
Mechanistic Insights Into 5′‐tiRNA‐His‐GTG Mediated Activation of the JNK Pathway in Skin Photoaging
Aging Cell, EarlyView.5′‐tiRNA‐His‐GTG expression level is upregulated in the photoaging cell model. 5′‐tiRNA‐His‐GTG negatively regulates the expression of NUP98, thereby activating the JNK signaling pathway to regulate cell senescence. ABSTRACT UV exposure leads to skin damage, thus inducing skin aging.
Lihao Liu +10 more
wiley +1 more source
Physico-chemical requirements and kinetics of membrane fusion of flavivirus-like particles. [PDF]
, 2015 Flaviviruses deliver their RNA genome into the host-cell cytoplasm by fusing their lipid envelope with a cellular membrane. Expression of the flavivirus pre-membrane and envelope glycoprotein genes in the absence of other viral genes results in the ...
core +1 more source
Arrestin‐centred interactions at the membrane and their conformational determinants
British Journal of Pharmacology, EarlyView.Abstract More than 30 years after their discovery, arrestins are recognised multiprotein scaffolds that play essential roles in G protein‐coupled receptor (GPCR) regulation and signalling. Originally named for their capacity to hinder GPCR coupling to G proteins and facilitate receptor desensitisation, arrestins have emerged as key hubs for a myriad of
Owen Underwood +3 more
wiley +1 more source
Localization of phosphatidylinositol 3-phosphate in yeast and mammalian cells [PDF]
, 2000 David J. Gillooly +7 more
openalex +1 more source
Increased fatty acyl saturation of phosphatidylinositol phosphates in prostate cancer progression. [PDF]
Sci Rep, 2019 Koizumi A +12 more
europepmc +1 more source
Myotubularin, a phosphatase deficient in myotubular myopathy, acts on phosphatidylinositol 3-kinase and phosphatidylinositol 3-phosphate pathway [PDF]
, 2000 F. Blondeau +5 more
openalex +1 more source
ERNEST COST action overview on the (patho)physiology of GPCRs and orphan GPCRs in the nervous system
British Journal of Pharmacology, EarlyView.G protein‐coupled receptors (GPCRs) are a large family of cell surface receptors that play a critical role in nervous system function by transmitting signals between cells and their environment. They are involved in many, if not all, nervous system processes, and their dysfunction has been linked to various neurological disorders representing important
Necla Birgül Iyison +15 more
wiley +1 more source