A Dictyostelium nuclear phosphatidylinositol phosphate kinase required for developmental gene expression [PDF]
, 2001 Kunde Guo +6 more
openalex +1 more source
Macrophages and autophagy: partners in crime
The FEBS Journal, EarlyView.Autophagy is a key regulator of macrophage function, influencing critical processes like polarization, cytokine secretion, and phagocytosis. Its impact on macrophage behavior varies across different tissues and disease contexts, where it can either promote protective responses or contribute to detrimental outcomes, depending on the physiological or ...
Alessandra Vitaliti +2 more
wiley +1 more source
Regulation of phosphatidylinositol-phosphate kinase IIgamma gene transcription by thyroid-stimulating hormone in thyroid cells [PDF]
, 2001 S Park +7 more
openalex +1 more source
PI5P4K inhibitors: promising opportunities and challenges
The FEBS Journal, EarlyView.Developing inhibitors is like climbing a steep, challenging mountain. PI5P4K inhibitors hold significant promise for the treatment of cancer, immune disorders, and neurological diseases. However, the path to success is fraught with hurdles, and researchers are therefore required to apply their expertise to overcome critical “checkpoints.” While some ...
Koh Takeuchi +16 more
wiley +1 more source
Regulation of Fab1 Phosphatidylinositol 3-Phosphate 5-Kinase Pathway by Vac7 Protein and Fig4, a Polyphosphoinositide Phosphatase Family Member [PDF]
, 2002 Jonathan D. Gary +5 more
openalex +1 more source
Insect Molecular Biology, EarlyView.Tomato spotted wilt virus modulated the abundance of gut proteins in larval thrips, most notably manifested as a predominant down‐regulation in first instar larvae. Gut‐expressed protein and cognate transcript abundance were moderately correlated across the tissue system; however, the virus effect varied widely at transcriptional and translational ...
Jinlong Han, Dorith Rotenberg
wiley +1 more source
PI3Kγ in Tumour Inflammation: Bridging Immune Response and Cancer Progression—A Mini‐Review
Immunology, EarlyView.Myeloid cell PI3Kγ can be activated by G Protein‐Coupled Receptors or Receptor Tyrosine Kinases. Once activated, PI3Kγ promotes integrin activation as well as Akt and mTOR activation, thereby promoting transcription of immune‐suppressive and pro‐angiogenic factors, such as Arginase, IL‐10, TGFβ and VEGF‐A.
Anghesom Ghebremedhin, Judith A. Varner
wiley +1 more source
Type IIα phosphatidylinositol phosphate kinase associates with the plasma membrane via interaction with type I isoforms [PDF]
, 2002 Katherine A. Hinchliffe +3 more
openalex +1 more source
Journal of Diabetes Investigation, EarlyView.Canagliflozin regulated the cyclic guanosine monophosphate (cGMP)‐protein kinase 1‐α signaling pathway through the natriuretic peptide B gene, thereby improving cell viability, apoptosis, and reactive oxygen species levels, and ultimately protecting cardiac function in type 2 diabetic patients with coronary artery disease.
Jiarui Zhang +5 more
wiley +1 more source
Inositol and PIP2/PIP3 Ratio: At the Crossroad of the Biodynamic Interface Between Cells and Their Microenvironment. [PDF]
BiomoleculesLentini G +4 more
europepmc +1 more source