Results 201 to 210 of about 77,486 (386)

MYO1C Binds to PiP2 With High Affinity Through a Putative Ph Domain [PDF]

, 2007
Myo1c is a member of the myosin superfamily that links the dynamic actin cytoskeleton to the membrane, and plays roles in mechano-signal transduction and membrane trafficking.
Hokanson, David
core   +1 more source

Cancer therapy‐related cardiotoxicity is associated with distinct alterations of the myocardial lipidome

European Journal of Heart Failure, EarlyView.
Lipidome changes in anthracycline‐induced cardiotoxicity (AIC). Aims Anthracyclines are key components of various chemotherapy regimens, but their clinical utility is limited by severe cardiotoxic side effects. Previous studies have suggested that anthracycline‐induced cardiotoxicity (AIC) may be driven by alterations in myocardial lipid metabolism ...
Vera M. Braun, Anna Foryst‐Ludwig, Ulf Landmesser, István Baczkó, Hendrik Milting, Ulrich Kintscher, Niklas Beyhoff   +6 more
wiley   +1 more source

Interpretation of in vitro concentration‐response data for risk assessment and regulatory decision‐making: Report from the 2022 IWGT quantitative analysis expert working group meeting

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Quantitative risk assessments of chemicals are routinely performed using in vivo data from rodents; however, there is growing recognition that non‐animal approaches can be human‐relevant alternatives. There is an urgent need to build confidence in non‐animal alternatives given the international support to reduce the use of animals in toxicity ...
Marc A. Beal, Guangchao Chen, Kerry L. Dearfield, Min Gi, Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Alexandra S. Long, David P. Lovell, Barbara L. Parsons, Stefan Pfuhler, John Wills, Andreas Zeller, George Johnson, Paul A. White   +14 more
wiley   +1 more source

Severity of effect considerations regarding the use of mutation as a toxicological endpoint for risk assessment: A report from the 8th International Workshop on Genotoxicity Testing (IWGT)

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Exposure levels without appreciable human health risk may be determined by dividing a point of departure on a dose–response curve (e.g., benchmark dose) by a composite adjustment factor (AF). An “effect severity” AF (ESAF) is employed in some regulatory contexts.
Barbara L. Parsons, Marc A. Beal, Kerry L. Dearfield, George R. Douglas, Min Gi, B. Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Michelle Kenyon, Alexandra S. Long, David P. Lovell, Anthony M. Lynch, Meagan B. Myers, Stefan Pfuhler, Alisa Vespa, Andreas Zeller, George E. Johnson, Paul A. White   +17 more
wiley   +1 more source

Evaluation of the effect of dietary supplementation with Allium mongolicum regel bulb powder on the volatile compound and lipid profiles of the longissimus thoracis in Angus calves based on GC–IMS and lipidomic analysis

Food Chemistry: X
The effect of A. mongolicum Regel bulb powder (AMRP) supplementation on the flavour of beef from Angus calves has not been investigated thus far. We used GC–IMS and untargeted lipidomics techniques to examine the volatile compound and lipid metabolic ...
Wangjing Liu, Huixia Gao, Jianjian He, Aihuan Yu, Chenxu Sun, Yaodi Xie, Haibo Yao, He Wang, Yueyan Duan, Jinsheng Hu, Zhaomin Lei, Defu Tang   +11 more
doaj  

Effects of secretagogues on [32P]phosphatidylinositol 4,5-bisphosphate metabolism in the exocrine pancreas [PDF]

, 1983
James W. Putney, Gillian M. Burgess, S P Halenda, J S McKinney, R P Rubin   +4 more
openalex   +1 more source

Sphingolipid synthesis is necessary for kinetoplast segregation and cytokinesis in Trypanosoma brucei [PDF]

, 2008
Almeida, Igor C., Engman, David M., Fridberg, Alina, Nakayasu, Ernesto S., Olson, Cheryl L., Tyler, Kevin M.   +5 more
core   +1 more source

Emerging Target Discovery Strategies Drive the Decoding of Therapeutic Power of Natural Products and Further Drug Development: A Case Study of Celastrol

Exploration, EarlyView.
Using celastrol as a case study, this review summarizes various target discovery strategies for natural products, including chemical proteomics, protein microarray, degradation‐based protein profiling, proteome‐wide label‐free approaches, network pharmacology, target‐based drug screening, and indirect strategies.
Yanbei Tu, Guiyu Dai, Yanyan Chen, Lihua Tan, Hanqing Liu, Meiwan Chen   +5 more
wiley   +1 more source

Analysis of the metabolic turnover of the individual phosphate groups of phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate. Validation of novel analytical techniques by using 32P-labelled lipids from erythrocytes [PDF]

, 1984
Phillip T. Hawkins, Robert H. Michell, C J Kirk   +2 more
openalex   +1 more source

Exploring the Molecular Pathways Underlying the Anti‐Diabetic Effects of Millets

Food Safety and Health, EarlyView.
Millet consumption may modulate gluconeogenesis and glycolysis, enhance glucose transporter activity, increase leptin levels, inhibit the NF‐κB pathway, and mitigate oxidative and nitrosative stress. ABSTRACT Diabetes mellitus (DM) is a metabolic disorder characterized by hyperglycemic conditions resulting from inadequate insulin production or ...
Akash Kumar, Nidhi N. Shah, Mehul R. Chorawala, Rekha Kaushik, Bhupendra Prajapati, Rahul Mehra   +5 more
wiley   +1 more source